Search Results - "metabolomics"

Summary: Mounting evidence suggests that metabolite exchange between microbiota members is a key driver of microbiota composition. However, we still know little about the metabolic interaction networks within many microbiota. To tackle this issue, we developed the porcine nasal consortium (PNC8), wh...

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Vitellogenesis is the most important stage of ovarian maturation in fish, involving the synthesis and transport of essential yolk substances and their complex mechanisms and coordination process. The liver is the main tissue involved in the vitellogenesis of oviparous animals, but studies of vitello...

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IntroductionPrecise screening and discriminating of prostatic hyperplasia (PH) could avoid unnecessary biopsy and overdiagnosis. However, the metabolic pattern of patients with prostatic hyperplasia in Chinese population is rarely reported.MethodsUrine samples of Chinese participants with prostate c...

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Summary: Preterm infants are frequently administered antibiotics to prevent infections, yet their impact on the developing gut microbiota and metabolome remains complex and clinically significant. To systematically assess these effects, we analyzed longitudinal stool samples from 54 extremely- and v...

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Accumulating epidemiological evidence has indicated that arsenic exposure can lead to kidney injury. However, the underlying mechanisms of arsenic-induced nephrotoxicity have not been fully elucidated. In this study, the effect of sodium arsenite on the cell viability of HEK-293 cells was studied us...

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<b>Background/Objectives</b>: Thousands of nephrectomies are performed annually in the United States, but the short-term metabolic effects of surgically induced renal ischemia remain unclear. The conventional metabolic markers used to characterize post-surgical renal function, such as cr...

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Over the past decade, microbial natural products research has witnessed a transformative “deep-mining era” driven by key technological advances such as high-throughput sequencing (e.g., PacBio HiFi), ultra-sensitive HRMS (resolution ≥ 100,000), and multi-omics synergy. These innovations have shifted...

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Summary: In this pilot study, we investigated three minimally to noninvasive biospecimens: cervicovaginal lavages (CVLs), vaginal swabs, and urine, from 18 premenopausal women using untargeted metabolomics to inform future gynecologic research. Metabolic profiles were compared between specimen types...

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Ultrasonic washing, as a form of abiotic stress, has been proven to trigger the biosynthesis of phenolic compounds (PCs) in fresh-cut red cabbages (FRCs). However, the related regulatory mechanisms remain unclear. This study preliminarily evaluated the enrichment mechanisms of PCs in FRCs under ultr...

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Tempe is a superior plant-based protein source that provides a diverse array of nutritional benefits as a result of the presence of bioactive metabolites. Nevertheless, there is a scarcity of information regarding the metabolomics profile between organic and conventional tempe and the fate of these...

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Background: Despite optimized blood pressure control and glycemic management reducing the incidence of diabetic nephropathy (DN), significant residual risk remains, suggesting the contribution of pathogenic factors independent of glucose metabolism and hemodynamic disturbances. Methods: Renal tissue...

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The mortality risk in systemic sclerosis (SSc) is primarily determined by pulmonary involvement (interstitial lung disease (ILD), pulmonary fibrosis), pulmonary arterial hypertension (PAH), and cardiac involvement. With timely and intensive treatment, the disease can be halted or even improved. Ther...

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Equine asthma is a chronic respiratory disease characterised by neutrophilic inflammation, airway hyperresponsiveness, and impaired pulmonary function. Obesity, increasingly prevalent among domestic horses, has been identified as a potential risk factor for exacerbating inflammatory conditions. This...

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To play a role effectively, biocontrol fungi must fight against plant immune response and establish a symbiotic interaction with their host. After successfully colonizing the host plant, the biocontrol fungi may deliver beneficial effects related to plant health and resistance against phytopathogens...

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According to FAO (Food and Agricultural Organization of the United Nation), potato is the fourth crop in terms of food production after rice, wheat and maize, and the first among the tubers and roots. The importance of potato is difficult to overestimate; it is a valuable source of carbohydrates, an...

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Background Heart failure (HF) is characterized by hemodynamic derangements that are likely to mediate systemic metabolic perturbations but limited data are available. Plasma metabolite profiling provides opportunities for comprehensive investigation of such perturbations. Here, we aimed to character...

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Various genetic and biochemical characteristics exist in tea plant cultivars, and they largely determine production suitability and tea quality. Here, we performed transcriptomic and metabolomic analyses of young shoots of seven tea cultivars and identified major regulatory transcription factors (TF...

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Salt stress is a significant abiotic factor that adversely impacts the yield of rapeseed (<i>Brassica napus</i> L.). Under salt stress conditions, the growth of rapeseed is markedly inhibited. This study integrates transcriptomic and metabolomic analyses to elucidate the molecular and ph...

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A comprehensive analysis of a series of metabolites that produced by the organisms in the life processes will help to reveal the biological links between genotype and phenotype. Metabolomics is the method to analyze the metabolites by “omics”, which includes genomics, transcriptomics, and proteomics...

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