Search Results - "mediation analysis"

BackgroundDigestive diseases impose a substantial global health burden, yet the joint impact of frailty and depression on their incidence remains underexplored.MethodsThis cohort study analyzed 5,506 adults aged ≥ 65 years from the China Health and Retirement Longitudinal Study (2011–2018). Particip...

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BackgroundStroke is a leading cause of mortality and disability worldwide. The relationship between hyperuricemia and stroke prognosis remains controversial. This study aims to investigate the association between hyperuricemia and stroke prevalence, as well as the impact of hyperuricemia on mortalit...

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ObjectiveThis study aimed to examine the association between the weight-adjusted waist circumference index (WWI) and the risk of depression in U.S. adults, as well as the potential mediating roles of chronic diseases (hypertension, diabetes, stroke, and coronary heart disease) in this relationship.M...

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BackgroundSchizophrenia is a complex， chronic and severe mental disorder， and the pathogenesis of which has not been fully elucidated. The abnormalities in lipid metabolism and circulating metabolomes have already been implicated in the pathophysiology of schizophrenia. However， available studies ha...

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ObjectiveInvestigate the association of physical activity enjoyment (PAE), physical activity (PA) and physical fitness (PF) among adolescents using a mediation model.Methods845 students (420 males, 425 females) were selected via stratified random cluster sampling. Demographic data were gathered thro...

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Cong Xu,1 Yonghong Xu,2 Ling Gao,3 Min Wang,1 Guangyan Wang,3 Guangming Wang1,4 1School of Clinical Medicine, Dali University, Dali, Yunnan, 671000, People’s Republic of China; 2Department of General Surgery, Banan Hospital Affiliated to Chongqing Medical University, Banan, Chongqing, 401320, People...

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Introduction and aims: Previous observational studies have reported an association between obesity and Bell’s palsy (BP), but the causality and the underlying mediating pathways remain unclear. We aimed to investigate the causal effects of adiposity across the life course on BP and to identify poten...

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The current paper focuses primarily on taxpayers’ perceptions regarding government performance (viz., transparency, taxation level, goods and services provided, political stability) and explores how these perceptions impact on tax compliance when trust in government counts as a mediating variable. T...

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Urolithiasis, a disease characterized by the formation of urinary stones, is influenced by immune system dysregulation and metabolic factors. This study investigated the interplay between specific immune cell characteristics and blood metabolites in urolithiasis based on Mendelian randomization. We...

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Foster care adolescents frequently experience heightened emotional and behavioral challenges. Although prior research has explored the link between social competence and resilience, the interplay of these factors specifically among foster care adolescents warrants further investigation. This study e...

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This study explores the intricate relationships among absorptive capacity, innovation, and financial performance in nonfinancial firms. Using data from COMPUSTAT spanning 1966 to 2020, including 25,392 observations, Tobin's Q is used as a measure of financial performance. Absorptive capacity, m...

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Background: The relationship between physical activity (PA), telomere length, and phenotypic age (PhenoAge) represents a pivotal area of investigation in aging research. Methods: The study encompassed a cohort of 6200 participants aged 20 years and above, sourced from the National Health and Nutriti...

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Background: Insomnia and osteoporosis are both prevalent conditions with rising incidence. Observational studies have suggested that insomnia may lead to thyroid dysfunction, which in turn contributes to osteoporosis. However, the interplay among these three conditions remains unexamined. This study...

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Understanding the relationship between Learned Helplessness (LH) and Psychological Capital (PsyCap) is essential for developing effective interventions for Indigenous adolescents. This study explored the role of PsyCap as a mediator in the link between LH and Psychological Well-Being (PWB). Total of...

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Background: Life’s Essential 8 (LE8) is known to have a negative correlation with biological aging, while the relationship between the Life’s Crucial 9 (LC9) score, which includes mental health, and biological aging remains to be further investigated. Methods: We obtained data from two national coho...

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This study examines the interconnected roles of microfinance access and financial literacy in enhancing business sustainability among women-led small and medium enterprises (SMEs) in Nigeria. Drawing on cross-sectional survey data from 3,421 women entrepreneurs across urban and peri-urban regions,...

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BackgroundDietary patterns influence the onset of metabolic syndrome (MetS) through the modulation of intestinal microbiota. Nevertheless, the relationship between the dietary index for gut microbiota (DI-GM), a novel metric for evaluating the link between diet and microbiota well-being, and its cor...

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Background: Negative symptoms (NS) are a core feature of schizophrenia spectrum disorders, yet their relationship with cognitive reserve (defined by educational attainment) and social cognition remains underexplored. This study examined whether education predicts NS and whether this relationship is...

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Background: Immune cells and plasma metabolites may play important roles in the development of pulmonary diseases, but the relationship between different immune cells, plasma metabolites and various pulmonary diseases is still unclear. In this study, we aim to employ Mendelian randomization (MR) to...

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ObjectiveThis study aims to investigate the relationship between serum calcium levels during hospitalization and the incidence and prognosis of sepsis in hospitalized patients with psoriasis.MethodsA retrospective analysis of patients with concomitant psoriasis admitted for the first time was conduc...

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