Torthaí cuardaigh - "major depressive disorders"

The central nervous system and the gastrointestinal tract are connected bidirectionally via the gut-brain axis (GBA). According to the gut microbiota hypothesis, changes in the composition and activity of the gut microbiota can affect the GBA, contributing to the onset of mental illnesses such as de...

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Schizophrenia (SCZ), Bipolar Disorder (BD), and Major Depressive Disorder (MDD) are severe psychiatric conditions that share overlapping clinical symptoms, yet they differ in their underlying molecular mechanisms. Despite extensive research, the biological foundations of these disorders remain incom...

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<h4>Background</h4>Major depressive disorder (MDD) is one of the important causes of disease burden in the general population. Given the experiencing rapid economic and social changes since the early 1990s and the internationally recognized diagnostic criteria and interview instruments a...

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<b>Background/Objective:</b> Depression is a widespread and complex disorder, constituting a major public health concern due to its significant impact on mental health. Because of the limitations of major depressive disorder (MDD) treatment, recent research on depression management has f...

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Background: Clinical heterogeneity and variations in methods to identify major depressive disorder (MDD) across studies compromise replicability of research findings. This study evaluated potential implications of different MDD case definitions in a large biobank cohort. Methods: Among Mayo Clinic B...

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Background Previous studies have found substantial costs to be associated with depression and insomnia (as separate entities). Aims To estimate healthcare service use and costs associated with insomnia in Australian adults experiencing subthreshold depression or major depressive disorder (MDD)....

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<h4>Background</h4>Major depressive disorder afflicts an estimated 17% of individuals during their lifetimes at tremendous suffering and costs. Cognitive therapy may be an effective treatment option for major depressive disorder, but the effects have only had limited assessment in system...

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Abstract Background Heterogeneous symptoms in major depression contribute to unsuccessful antidepressant treatment, termed treatment-resistant depression (TRD). Psychometric network modeling conceptualizes depression as interplay of symptoms with potential benefits for treatment; however, a knowledg...

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Background: Millions of people worldwide are affected by major depressive disorder (MDD). However, those with MDD do not receive treatment. More studies have been conducted on the efficacy of medications rather than the subjective experiences of mental healthcare users (MHCUs). Aim: This study was...

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Fengtao Guo,1,2 Ying Li,2,3 Junxiang Cheng,1,2 Xinxia Wang,1,2 Wei Hu,1,2 Kun Zhang,4 Xushu Jing,1,2 Jinrui Xing,1,2 Zhifen Liu,1 Huanhu Zhang,2,5 Penghong Liu1,2 1Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Shanxi Medical Univ...

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Aims: We aimed to determine differences in subgenual anterior cingulate cortex (sgACC) resting-state functional connectivity (rsFC) in Major Depressive Disorder (MDD) vs. healthy volunteers (HV) using 7-Tesla functional magnetic resonance imaging (fMRI). Abnormalities in the sgACC are linked to MDD,...

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Marital problems are one of the leading causes of depression in low income countries. In collectivistic cultures, inability to bear child makes individual more vulnerable towards depression. An increasing body of literature suggests the efficacy of solution-focused brief therapy for depressive diso...

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Qunlian Huang,1 Xiaoyan Zhong,1 Ye Yun,1 Bin Yu,2 Yilan Huang1 1Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, 2Department of Clinical Pharmacy, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan Province, People&amp;rsquo;s Republic of China Ob...

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ABSTRACT Pharmacogenetics is a promising strategy to facilitate individualized care for patients with Major Depressive Disorder (MDD). Research is ongoing to identify the optimal genetic markers for predicting outcomes to antidepressant therapies. The primary aim of this systematic review was to sum...

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Major Depressive Disorder (MDD) is a chronic mental disorder characterized by anhedonia, loss of desire, guilt, suicidal thoughts, and appetite changes. It is reported that individuals with MDD resort to binge eating to escape from negative feelings. In this study, we aimed to determine the relation...

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Background: In animal and human cross-sectional studies, methyl-CpG-binding protein 2 (MeCP2) is associated with depression. But studies examining alterations in MeCP2 levels in patients with depression receiving antidepressant treatment are scarce. Methods: In this study, we intended to collect blo...

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An accurate diagnostic method using biological indicators is critically needed for bipolar disorder (BD) and major depressive disorder (MDD). The excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is a crucial regulator of synaptic function, and its dysregulat...

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Takahiro Tsutsumi,1 Hiroko Sugawara,1,2 Ryoko Ito,1 Mizuho Asano,1 Satoru Shimizu,3 Jun Ishigooka,1 Katsuji Nishimura1 1Department of Psychiatry, 2Support Center for Women Health Care Professionals and Research, 3Department of Research, Medical Research Institute, Tokyo Women&amp;rsquo;s Medica...

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