Search Results - "leukemia"

Patients with acute leukemia are one of the most vulnerable risk groups for infection with SARS-CoV-2 and severe course of coronavirus infection. During the first 2 years of the pandemic, the mortality rate of patients with acute leukemia was 11-48 %, depending on leukemia type, and only reached pop...

Full description

Feline leukemia virus is a highly infectious virus among cats, spread primarily via saliva, mutual grooming and aggressive behaviors. This virus cause disorders of hematopoiesis, immune suppression, anemia lymphomas and leukemias. Blood samples were obtained from a client owned 4 years male cat pres...

Full description

Abstract. We examined immunological state in 100 patients with acute non-lymphoblastic leukemia (ANLL, M4), and in 73 cases of acute lymphoblastic leukemia (ALL, common variant). The most expressed disturbances of immune status in ANLL patients were revealed during relapses, and in patients with ALL...

Full description

Bone marrow tumor blasts immunophenotyping is an essential part of Burkitt lymphoma/leukemia (BL) and B-cell precursor acute lymphoblastic leukemia (BCP-ALL) differential diagnostics. Nevertheless immunoglobulin heavy and light chains detection on the cell surface could meet several biological and m...

Full description

Introduction. Surface immunoglobulin expression is a main immunophenotypic criteria of mature subtype of B-lineage acute lymphoblastic leukemia. Although the majority of such cases represents Burkitt leukemia/lymphoma, it was shown for several times that membrane IgM could be detected in the absence...

Full description

Enzootic bovine leukemia is an infectious disease with a chronic course caused by an RNA‑containing virus of the genus Deltaretrovirus. Despite the implementation of various programs for the elimination of leukemia, the disease is still widespread on the planet and continues to cause significant eco...

Full description

In consequence of the development of modern chemotherapy protocols, the prognosis for children with acute leukemia(AL) has significantly improved, which has allowed achieving high survival rates. However, despite these achievements, relapses and refractory course of AL are not uncommon. Extramedulla...

Full description

Introduction of the immunophenotyping in 70-ties and 80-ties of the past century has led to significant revision of conception of hematological malignancies. A new era in developement of medicine and oncology in particular is related to functional genomics. This field of molecular biology attempts t...

Full description

Chronic myeloid malignancies that have characteristics of both the myelodysplastic and myeloproliferative disorders allocated to myelodysplastic/myeloproliferative diseases (MDS/MPD) group in 2008 World Health Organization classification. This group includes chronic myelomonocytic leukemia, juvenile...

Full description

Summary: Over the past decade, measurable residual disease (MRD) has emerged as a critical tool for detecting and monitoring a variety of cancers, but particularly hematologic malignancies. The rapid adaptation of this novel approach to monitoring disease status is intuitively appealing: it offers s...

Full description

Acute leukemia is a formidable disease that often leads to the death of the patient from the underlying disease or the consequences of severe chemotherapy treatment. Many prognostically unfavorable factors are known, including genetic and epigenetic ones. The review is devoted to the prognostic sign...

Full description

The aim of the study was to study the relationship between the qualitative and quantitative characteristics of myelofibrosis and the clinical manifestations of chronic myeloid leukemia and chronic lymphocytic leukemia. Material and methods. A complex pathomorphological study of ilium bone trepanobio...

Full description

Abstract. We examined metabolic status of blood lymphocytes in forty-four patients with chronic myeloid leukemia (CML), and in fifty-seven patients with chronic lymphoid leukemia (CLL). The most pronounced changes of enzyme activities are found in blood lymphocytes of CML and CLL patients during ter...

Full description

Immunotherapy has emerged as a cornerstone strategy for augmenting therapeutic efficacy in acute myeloid leukemia (AML). The immunosuppressive AML microenvironment, characterized by profound immune dysfunction, critically impairs anti-leukemic immune surveillance. This immunologically hostile niche...

Full description

Chronic basophilic leukemia (CBL) is a rare disorder and according to the published data, few cases have been reported as primary CBL. Morphologic findings in CBL mostly mimic chronic eosinophilic leukemia and basophils have unusual and dysplastic morphology. A 47-year-old patient was referred to th...

Full description

Plasma cell leukemia is a rare, aggressive disease characterized by clonal proliferation of plasma cells, having many features of both plasma cell neoplasms and acute leukemia. despite significant changes in therapeutic approaches, the prognosis for this disease remains unfavorable. The article desc...

Full description

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm driven by the BCR::ABL1 fusion gene and typically progresses through chronic, accelerated, and blast crisis phases. While blast crises often present with myeloid or lymphoid phenotypes, transformation to acute undifferentiated leukemia...

Full description

Acute leukemia (AL) in children up 1 year old is very rare disease, comprise less 5 % of all pediatric AL cases. The clinical course of infant AL is extremely aggressive with frequent extramedullar dissemination, initial hyperleukocytosis and MLL aberrations. Predominance of unfavorable clinical and...

Full description

The article summarizes data on the effect of biologically active substances with immunoprotective properties on immune indices and nonspecific immunity as well possibilities of their use to protect young cattle from infection with the bovine leukemia virus (BLV). It has been established that combine...

Full description

Objective: Autoimmune hemolytic anemia (AIHA), thrombocytopenia, neutropenia and some other autoimmune diseases can be observed in the context of lymphoproliferative diseases and after hematopoietic stem cell transplantation (HSCT). Among these, AIHA is a rare red blood cell disorder; however, the c...

Full description