Search Results - "immunosuppression"

Abstract. Over the past decade a population of so–called “regulatory T cells” (Treg cells) has been linked to the prevention of autoimmunity. In this review we discuss the molecular mechanisms of Treg cells development and function including the identification of the unique molecular marker of Treg...

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The efficiency of the advagraf as the main immunosuppressant in renal transplant recipients in the early postoperative period has been assessed. A good tolerability of the medicament has been confirmed. Satisfactory performance of renal graft function recovery after surgery was marked. Recommendatio...

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Abstract. In present work, an immunocorrective effect of phenotropil after intraperitoneal injection (50 mg/kgx3) was studied in CBA mice. The drug was administered either before antigenic stimulation, and/or cyclophosphamide-induced immunosuppression, or at the terms of evolving immune deficiency....

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Infertility issues, regarded as an important component of modern medicine, which are, at the same time, a significant public problem, are becoming relevant for the elderly due to the increase in the average life expectancy. Alongside with that, in recent years, the negative impact of a complex of an...

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Aim. The aim was to study the morphological characteristics of the testes of experimental animals during the period of pronounced senile changes at artificial suppression of the immune system.Materials and methods. The study was carried out on 60 white rats with pronounced senile changes. Immunosupp...

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Rabbit anti-thymocyte immunoglobulin, Thymoglobulin, was first obtained over 25 years ago and currently it is the most widely used antilymphocytic immunoglobulin in solid organ transplantation. Thymoglobulin interacts with a broad range of surface antigens of T-lymphocytes, natural killer cells, B-l...

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The purpose is improving the prediction of the immune status dynamics in children with HIV infection, taking into account independent predictors.Materials and methods. Clinical, immunological, molecular genetic examination of 91 pairs «HIV-infected mother – child with HIV infection» was carried out....

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The article on the immunodeficiency model describes the influence of autolysates isolated from yaks spleen on the performance of cellular and. humoral immune response of experimental animals (mice). Neurotropic activity of these funds was estimated. Found, that thymic growth stimulate activity corre...

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Introduction: Paracoccidioidomycosis is an endemic mycotic infection caused by Paracoccidioides spp., prevalent in Central and South American countries. Anti-tumor necrosis factor (TNF) alpha agents, commonly used for autoimmune diseases, increase the risk of severe infections. We present a case of...

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The influence of artificial immunodeficiency state upon brucellosis course has been studied experimentally. Trials on laboratory animals demonstrated faster and more intensive progression of infectious process as well as increased frequency of the fatal cases of the disease caused by brucellosis age...

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Background. Kidney transplantation efficacy is limited by immunosuppression nephrotoxicity, antibody-mediated and chronic rejection. Avoiding immunosuppression nephrotoxicity is a promising strategy to improve long term outcomes. Belatacept, a synthetic immunoglobulin which blocks CD28-B7 pathway of...

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We have investigated in vivo effects of quercetin dihydrate (QD) upon course of respiratory allergy produced in experimental murine model. To provoke allergy, serum ovalbumin (OVA) was injected at different terms. Following administration of QD at the stage of OVA sensitization, the balance of T-hel...

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Malignancy is one of the leading causes of death in recipients with a kidney grafts. The use of proliferative signal inhibitors (PSI) is one of the approaches to solve this problem.Aim: to evaluate the effi cacy and safety of everolimus in combination with reduced dose of calcineurin inhibitors (CNI)...

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Actinic keratosis (AK) is a precancerous lesion that develops on chronically sun-exposed skin. Immunosuppression is known to increase the risk of both AK and other cancers, highlighting the need to evaluate potential associations between AK and subsequent nonskin cancers. To determine whether a diag...

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Many pathogens use metabolic pathway of arginine for successful dissemination. Bacterial arginine deiminase hydrolyzes arginine to form one molecule of ammonia and two molecules of ATP. The activity of the enzyme contributes to the improvement of survival of pathogenic bacteria in conditions of low...

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Abstract The immunosuppressive tumor microenvironment of glioblastoma limits the effectiveness of most immunotherapies. Transforming growth factor (TGF)-β signaling drives tumor progression and prevents effective T cell activity. Notably, both regulatory T cells (Tregs) and effector T cells within g...

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The last fifteen years have been marked by rapid progress in the study of neutrophils. The discovery of transcriptional plasticity of neutrophils, their phenotypic and functional heterogeneity contributed to launching active interdisciplinary studies on the role of neutrophils in various chronic inf...

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Summary: Immunosuppression, characterised by impaired immune function, significantly influences infection risk and ICU admissions in critically ill patients. This manuscript highlights the need for grading criteria to assess pre-existing immunosuppression, considering factors like underlying disease...

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