Search Results - "immunology"

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  1. 1
    The Ruminant immune system in health and disease /

    The Ruminant immune system in health and disease /

    Published 1986 Subjects: “…Veterinary immunology.…”
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  2. 2
    Immunobiology

    Immunobiology by Inchley, Christopher J.

    Published 1981 Subjects: “…Immunology…”
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  3. 3
    The thorn in the starfish : how the human immune system works /

    The thorn in the starfish : how the human immune system works / by Desowitz, Robert S.

    Published 1987 Subjects: “…Immunology.…”
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  4. 4
    Immunology : an outline of basic principles, problems and theories concerning the immunological behaviour of man animals /

    Immunology : an outline of basic principles, problems and theories concerning the immunological behaviour of man animals / by Gray, David F.

    Published 1970 Subjects: “…Immunology.…”
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  5. 5
    FUNDAMENTAL STUDIES IN BASIC AND CLINICAL IMMUNOLOGY PERFORMED BY ACADEMICIAN V.I. IOFFE (TO THE 120th ANNIVERSARY OF THE BIRTH OF ACADEMICIAN V.I. IOFFE)

    FUNDAMENTAL STUDIES IN BASIC AND CLINICAL IMMUNOLOGY PERFORMED BY ACADEMICIAN V.I. IOFFE (TO THE 120th ANNIVERSARY OF THE BIRTH OF ACADEMICIAN V.I. IOFFE) by P. G. Nazarov, I. S. Freydlin

    Published 2018-06-01

    In 2018, we celebrate the 120th anniversary of Academician, Professor Vladimir I Ioffe, a leading figure of national immunology. The world-level achievements of V.I.Ioffe in research, his undisputed priority in the most important areas of fundamental immunology are worth of recognition and interest...

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    Subjects: “…basic immunology…”
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  6. 6
    New horizons in microbiology proceedings of the European Symposium on New Horizons in Microbiology held at the Facolta di medicina e chirurgia A. Gemelli, Universita cattolica del Sacro Cuore, Rome, Italy, on April 26-28, 1984

    New horizons in microbiology proceedings of the European Symposium on New Horizons in Microbiology held at the Facolta di medicina e chirurgia A. Gemelli, Universita cattolica del...

    Published 1984 Subjects:
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  7. 7
    Veterinary immunology

    Veterinary immunology by Outteridge, P. M. (Peter M.)

    Published 1985 Subjects: “…Veterinary immunology…”
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  8. 8
    Veterinary immunology : an introduction /

    Veterinary immunology : an introduction / by Tizard, Ian R.

    Published 1987 Subjects: “…Veterinary immunology.…”
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  9. 9
    A hypomorphic Il2rb mutant mouse model recapitulates and reveals mechanisms of human T cell immune dysregulation in IL-2Rβ deficiency

    A hypomorphic Il2rb mutant mouse model recapitulates and reveals mechanisms of human T cell immune dysregulation in IL-2Rβ deficiency by Berenice Cabrera-Martinez, Josselyn E. Garcia-Perez, Ryan M. Baxter, Victor G. Lui, Tusharkanti Ghosh, Ahmet Eken, Zander Kostka-Newman, John Rhey Mhar Garcia, Jeremy Rahkola, Rachel L. Gessner, Cullen M. Dutmer, Jared Klarquist, Eric M. Pietras, Debashis Ghosh, Sara A. Johnson, Ross M. Kedl, Elena W.Y. Hsieh

    Published 2025-07-01

    Summary: Here, we describe the use of a homologous knockin mouse model to further decipher the mechanism(s) of a novel human homozygous IL2RB hypomorphic mutation. Our model recapitulates the human immune dysregulation phenotype, showing decreased mutant interleukin-2Rβ (IL-2Rβ) cell-surface express...

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    Subjects: “…CP: Immunology…”
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  10. 10
    Granulysin-high decidual NK cells in macaques and humans share signatures of immune defense

    Granulysin-high decidual NK cells in macaques and humans share signatures of immune defense by Nina Salinger Prasanphanich, Giulia Protti, Monica Cappelletti, Feiyang Ma, Neema Pithia, Angel Dasenbrock, Jerzy Stanek, Claire A. Chougnet, Suhas G. Kallapur, Matteo Pellegrini, Tamara Tilburgs, Pietro Presicce

    Published 2025-07-01

    Summary: Decidual natural killer cells (dNKs) are key immune effector cells at the maternal-fetal interface. dNKs utilize the antimicrobial peptide granulysin (GNLY) to kill bacteria without killing infected trophoblasts. Since rodents lack the GNLY gene, the in vivo biology of GNLY expression by dN...

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    Subjects: “…CP: Immunology…”
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  11. 11
    Sca-1 expression depicts pro-inflammatory murine neutrophils under steady-state and pathological conditions

    Sca-1 expression depicts pro-inflammatory murine neutrophils under steady-state and pathological conditions by Milind Nahiyera, Supriya Sinha, Priyanka Dhankani, Apurwa Singhal, Abhinav Singh, Rakesh Kumar Sharma, Ambalika Gond, Prayrna Atter, Kanchan Gupta, Kalyan Mitra, Amit Lahiri, Kumarvelu Jagavelu, Marie-Dominique Filippi, Madhu Dikshit, Sachin Kumar

    Published 2025-07-01

    Summary: Neutrophils play a critical role in various pathophysiological conditions. However, their therapeutic targeting has been challenging due to the associated risk of infections. Therefore, identifying disease-associated neutrophil populations is essential for targeted strategies. This study id...

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    Subjects: “…CP: Immunology…”
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  12. 12
    BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4

    BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4 by Laura Conter, Shuchi Smita, Derrick Callahan, Shuxian Wu, Aiden Brown, Kevin M. Nickerson, Rebecca A. Elsner, Wenzhao Meng, Ayelet Peres, Gur Yaari, Steven H. Kleinstein, Eline T. Luning Prak, Wei Luo, Mark Shlomchik

    Published 2025-07-01

    Summary: In B cells, BLIMP1 is required for plasma cell differentiation. BLIMP1 is also expressed in some germinal center (GC) B cells (GCBC), yet the role of BLIMP1 in GCBC is not understood. Here we generated mixed bone marrow (BM) chimeric mice using Prdm1+/+ CD19Cre and Prdm1fl/fl CD19Cre BM, al...

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    Subjects: “…CP: Immunology…”
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  13. 13
    Modulation of B cell receptor activation by antibody competition

    Modulation of B cell receptor activation by antibody competition by Yuanyuan He, Zijian Guo, Michael D. Vahey

    Published 2025-07-01

    Summary: During repeated virus exposure, pre-existing antibodies can mask viral epitopes by competing with B cell receptors for antigen. Although epitope masking has the potential to steer B cell responses away from conserved epitopes and toward those that are antigenically novel, the factors that i...

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    Subjects: “…CP: Immunology…”
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  14. 14
    Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma

    Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma by Shun Deng, Rilin Deng, Jinfeng Wang, Qi Hu, Biaoming Xu, Jinhai Zheng, Mingjing Peng, Wenzhi Tan, Haizhen Zhu, Chaohui Zuo

    Published 2025-08-01

    Summary: The strong immunosuppression and immune evasion of pancreatic ductal adenocarcinoma (PDAC) result in poor efficacy of immune checkpoint blockade. In this study, the PD-1 level on CD8+ T cells in the peripheral blood of patients with PDAC was significantly greater than that in the peripheral...

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    Subjects: “…Immunology…”
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  15. 15
    Ex vivo model of functioning human lymph node reveals role for innate lymphocytes and stroma in response to vaccine adjuvant

    Ex vivo model of functioning human lymph node reveals role for innate lymphocytes and stroma in response to vaccine adjuvant by Joannah R. Fergusson, Jacqueline H.Y. Siu, Nitya Gupta, Edward Jenkins, Eloise Nee, Sören Reinke, Tamara Ströbel, Ananya Bhalla, Shyami M. Kandage, Thomas Courant, Sarah Hill, Moustafa Attar, Michael L. Dustin, Alex Gordon-Weeks, Mark Coles, Calliope A. Dendrou, Anita Milicic

    Published 2025-07-01

    Summary: Immunological processes that underpin human immune responses to therapeutics and vaccine components, such as vaccine adjuvants, remain poorly defined due to a paucity of models that faithfully recapitulate immune activation in lymphoid tissues. We describe precision-cut human lymph node (LN...

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    Subjects: “…CP: Immunology…”
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  16. 16
    Immune signaling mediates stromal changes to support epithelial reprogramming in celiac duodenum

    Immune signaling mediates stromal changes to support epithelial reprogramming in celiac duodenum by Dylan Richards, Klebea Sohn, Shrikanth Chomanahalli Basavarajappa, Daniel Horowitz, Joshua Rusbuldt, Lynn Tomsho, Kate Paget, Ivan Chavez, Koen Van den Berge, Brad McRae, Heather Loughnane, Seamus Hussey, Patrick Walsh, Darren Ruane

    Published 2025-08-01

    Summary: Celiac disease is a chronic autoimmune disorder affecting 0.5%–1% of the population. Here, we assembled the most comprehensive single-cell RNA sequencing (scRNA-seq) dataset in celiac disease (CeD) to date, including 203,555 cells across 21 active CeD and 11 control duodenal samples. CeD wa...

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    Subjects: “…CP: Immunology…”
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  17. 17
    Lymph node fibroblast phenotypes and immune crosstalk regulated by podoplanin activity

    Lymph node fibroblast phenotypes and immune crosstalk regulated by podoplanin activity by Spyridon Makris, Yukti Hari-Gupta, Jesús A. Cantoral-Rebordinos, Victor G. Martinez, Harry L. Horsnell, Agnesska C. Benjamin, Isabella Cinti, Martina Jovancheva, Daniel Shewring, Nicola Nguyen, Charlotte M. de Winde, Alice E. Denton, Sophie E. Acton

    Published 2025-07-01

    Summary: Lymph nodes are uniquely organized niches for immune interactions. Fibroblastic reticular cells (FRCs) facilitate immune cell communication and regulate immune function by producing growth factors, chemokines, and inflammatory cues. Stromal expression of the glycoprotein podoplanin (PDPN) i...

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    Subjects: “…CP: Immunology…”
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  18. 18
    Plasma extracellular vesicle surface-located GAS6/PROS1 and CD39/CD73 attenuate inflammation

    Plasma extracellular vesicle surface-located GAS6/PROS1 and CD39/CD73 attenuate inflammation by Martina P. Fabiano, Alan M. Adamczyk, Olesia A. Gololobova, Ignacio G. Mazzitelli, María L. Leicaj, Tomás M. Grosso, Paula S. Pérez, Cora L. Alvarez, Julieta Schachter, Silvina Palmer, Florencia Sabbione, Fernando A. Erra Díaz, Analía S. Trevani, Manuel Varas-Godoy, Eugenio A. Carrera Silva, Kenneth W. Witwer, Matías Ostrowski

    Published 2025-08-01

    Summary: Herein, we demonstrate that extracellular vesicles (EVs) present in healthy human plasma regulate macrophage activation by triggering MERTK-dependent signaling in a growth arrest-specific 6 (GAS6)- and protein S (PROS1)-dependent manner. Moreover, EVs regulate oxidative burst and degranulat...

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    Subjects: “…CP: Immunology…”
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  19. 19
    A rare B cell clonotype imprinted by ancestral SARS-CoV-2 develops cross-sarbecovirus neutralization in immune recalls

    A rare B cell clonotype imprinted by ancestral SARS-CoV-2 develops cross-sarbecovirus neutralization in immune recalls by Xixian Chen, Ling Li, Ruiping Du, Zuowei Wang, Yunjian Li, Yi Sun, Rongrong Qin, Hualong Feng, Lin Hu, Xuanyi Chen, Maosheng Lu, Xueyan Huang, Haibo Wang, Liwei Jiang, Teng Zuo

    Published 2025-07-01

    Summary: The ultimate potential of B cells imprinted by ancestral SARS-CoV-2 in developing neutralizing breadth and potency remains to be explored. Here, we longitudinally tracked B cells that recognize the wild-type spike in two individuals who were repeatedly infected by Omicron variants after rec...

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    Subjects: “…CP: Immunology…”
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  20. 20
    Structural and functional insights into the evolution of SARS-CoV-2 KP.3.1.1 spike protein

    Structural and functional insights into the evolution of SARS-CoV-2 KP.3.1.1 spike protein by Ziqi Feng, Jiachen Huang, Sabyasachi Baboo, Jolene K. Diedrich, Sandhya Bangaru, James C. Paulson, John R. Yates, III, Meng Yuan, Ian A. Wilson, Andrew B. Ward

    Published 2025-07-01

    Summary: The JN.1-sublineage KP.3.1.1 recently emerged as the globally prevalent SARS-CoV-2 variant, demonstrating increased infectivity and antibody escape. We investigate how mutations and a deletion in the KP.3.1.1 spike protein (S) affect hACE2 binding and antibody escape. Mass spectrometry conf...

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    Subjects: “…CP: Immunology…”
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