Search Results - "ferroptosis"

Ferroptosis is a regulated form of cell death characterized by iron-dependent lipid peroxidation. Since its initial description, it has garnered significant attention due to its implications in various diseases, including cancer, neurodegeneration, and ischemia-reperfusion injury. The ageing process...

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<b>Background</b>: Intervertebral disc degeneration (IVDD) is a major cause of chronic back pain. Recent studies suggest that ferroptosis, a form of cell death, contributes to the degeneration of nucleus pulposus cells (NPCs). This study explores a novel therapeutic strategy using cell-f...

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Obesity represents one of the major public health issues threatening the global health and promoting chronic metabolic disorders, including type 2 diabetes, insulin resistance (IR), hyperlipidemia, hypertension, polycystic ovary syndrome, metabolic-associated fatty liver disease (MAFLD), and others....

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This study aimed to investigate whether lipopolysaccharide (LPS)-induced intestinal inflammation involves ferroptosis and its impact on broiler gut health. Two animal trials were conducted. In the first trial, 192 ROSS 308 broilers were randomly assigned to four groups and intraperitoneally injected...

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ABSTRACT Background Hepatocellular Carcinoma (HCC) ranks among the most prevalent human cancers and stands as the third most common cause of death related to cancer globally. Current therapies for HCC include surgical resection, local ablation, chemoembolization, liver transplantation, and molecular...

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Microplastics are tiny plastic particles originating from both commercial product manufacturing and the degradation of larger plastic materials. These particles pose significant risks to environmental and animal health. A growing body of evidence highlights plastic packaging as a major source of mic...

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Hypoxia as a hallmark of solid malignancies compromises therapeutic efficacy and prognosis. This study deciphers the functional role of hypoxia-induced ferroptosis in glioma prognosis. Hypoxia-related transcripts and ferroptosis markers were curated from public databases. ConsensusClusterPlus identi...

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ObjectiveThe primary approach to the treatment of glioma involves surgical intervention, which is often complemented by radiotherapy, chemotherapy, and electric field therapy. Nevertheless, the prognosis for many patients remains poor. There exists an urgent necessity to identify novel replacement t...

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Type 2 diabetes mellitus (T2DM) is associated with an elevated risk of neurodegenerative diseases, yet the underlying mechanisms remain elusive. A hallmark feature of T2DM is the amyloid deposition of islet amyloid polypeptide (IAPP) in the pancreas, which may contribute to both pancreatic dysfuncti...

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<b>Introduction:</b> As a ubiquitous environmental pollutant, methylmercury (MeHg) induces toxic effects in the nervous system [...]

Ferroptosis is a newly discovered form of programmed cell death, primarily caused by an imbalance between iron-dependent oxidative damage and antioxidant defense mechanisms within the cell. It differs from previously reported forms of cell death, such as apoptosis, necrosis, and autophagy, in terms...

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Background: Osteoarthritis (OA) is the most common degenerative joint disease, characterized by cartilage deterioration, which is closely associated with chondrocyte ferroptosis. The aim of this study was to investigate the role and mechanism of previously unexplored gene, growth factor independence...

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Purpose The purpose of this review is to discuss the role of fat-soluble vitamins in bone metabolism and explore whether there is a relationship between each fat-soluble vitamins in the occurrence and development of osteoporosis.Methods We selected several databases, including PubMed, PubMed Central...

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Aim – to study the clinical manifestations of rheumatoid arthritis (RA) and the spectrum of concomitant diseases, depending on the level of hepcidin in patients with high inflammatory activity.Material and methods. The analysis included 78 patients (48.9±15.5 years) with RA, disease duration of 108...

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ABSTRACT Aim Artemisinins are a class of antimalarial drugs that are lately being researched for their antitumor activity. We previously reported that artesunate, an artemisinin derivative, can induce ferroptosis and enhance TRAIL (Tumor necrosis factor‐Related Apoptosis‐Inducing Ligand)‐induced apo...

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Yanqiu Sun, Jian Liu, Mingyu He, Dan Huang, Yuan Wang Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui, 230038, People’s Republic of ChinaCorrespondence: Jian Liu, Department of Rheumatology and Immunology, First A...

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Intravascular hemolysis is a common event in the pathogenesis of numerous diseases with heterogeneous etiologies and clinical features. A frequent adverse effect of massive hemolysis is kidney injury, which is a major cause of increased morbidity and mortality in chronic hemolytic diseases. However,...

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Nasopharyngeal carcinoma (NPC) is a kind of malignant tumour originating from the mucosal epithelium of the nasopharynx, which has apparent regional distribution characteristics, and its incidence is increasing yearly. At present, the primary treatment method for nasopharyngeal carcinoma is radiothe...

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Jiahui Li, Limei Fan, Yu Nan, Min Wang, Shuli Yang Department of Gynecology and Obstetrics, The Second Hospital of Jilin University, Changchun, Jilin, 130000, People’s Republic of ChinaCorrespondence: Shuli Yang, The Second Hospital of Jilin University, No. 4026, Yatai Street, Nanguan District, Chan...

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