Search Results - "cell proliferation"

Background: Smoking and alcohol use are major risk factors for oral cancer, one of the most common diseases in the world. To better understand their involvement in tumor development, this in vitro research assesses the individual and combined effects of alcohol and smoking on the growth of oral canc...

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Aurora kinase B (AURKB), a serine/threonine protein kinase, is essential for accurate chromosome segregation and cytokinesis during mitosis. Dysregulation of AURKB, often characterized by its overexpression, has been implicated in various malignancies, including breast cancer. However, the mechanism...

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FTO expression correlates with adipose tissue development in rabbits, yet its regulatory role in preadipocyte differentiation remains poorly understood. Therefore, we employed transcriptome sequencing to identify 422 differentially expressed genes (DEGs) between the FTO overexpression group and the...

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Follicle-stimulating hormone (FSH), an important hypothalamic-pituitary-gonadal axis (HPG) hormone, is secreted by the pituitary gland. This study confirms that FSH is expressed in chicken follicles at different stages, and positive FSHβ mRNA signals were stronger (P<0.05) in granulosa cells than...

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The sulforhodamine B (SRB) assay is a robust and cost-effective methods for assessing cellular proliferation and cytotoxicity in vitro. Originally designed to support drug screening efforts at the National Cancer Institute, this colorimetric assay quantifies protein content as a proxy for cell numbe...

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Background. Current immunohistochemical identification of prognostic markers of the pancreatic ductal adenocarcinoma needs to be improved, as it helps to estimate the rate of invasion and innidiation, and consequently give an opportunity to predict the individual behavior of tumor in every case. Obj...

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Human cytomegalovirus (HCMV) infection and its association with tumorigenesis and tumor progression have garnered increasing attention. Previous research results have indicated that the detection rate of HCMV UL82 is higher in colorectal cancer (CRC) tissues and is correlated with poor prognosis in...

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Previously, we reported that mammalian cells, specifically human dermal fibroblasts (HDFs), could be transdifferentiated by lactic acid bacteria (LAB). Later, we observed that HDFs incorporated LAB-derived ribosomes, forming the ribosome-induced cell clusters (RICs) and transdifferentiating into cel...

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Objectives: Nanothechnology found to be increasingly implemented in implantology sphere over the recent years and it shows encouraging effect in this field. The aim of present review is to compare, based on the recent evidence, the influence of various nanostructure surface modifications of titanium...

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STRAP (serine-threonine kinase receptor-associated protein), a WD domain-containing 38.5 kDa protein, was first identified in TGF-ß signaling and participates in scaffold formation in numerous cellular multiprotein complexes. It is involved in the regulation of several oncogenic biological processes...

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Angiogenesis is one of the first stages in fracture healing and bone repair. Therefore, numerous studies evaluating the effect of Mg as a promising degradable, metallic biomaterial on the proliferation and function of endothelial cells have been performed. However, these studies lack methodological...

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Aberrant ubiquitination drives hepatocellular carcinoma (HCC) progression, yet the role of FBXO10—a key F-box E3 ubiquitin ligase component—remains uncharacterized. Through bioinformatics analyses and functional validation, we establish FBXO10 as a critical oncogenic driver in HCC. Transcriptomic da...

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5-aminolevulinic acid (5-ALA) is a widely recognized and effective tool for improving tumor resections during surgical interventions but may directly interact with cells in the tumor microenvironment. Nevertheless, there remains an ongoing debate regarding the impact of 5-ALA on neural stem cells (N...

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Myocardial infarction leads to cardiomyocyte loss, and the compromised proliferative capacity of cardiomyocytes after birth hinders the process of heart repair, ultimately culminating in heart failure. Extracellular vesicles (EVs), known as cell-secreted “messengers”, play a pivotal role in tissue p...

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Objective(s): One of the leading causes of endometriosis is the return of menstrual blood flow into the pelvic cavity and the establishment of menstrual blood mesenchymal stem cells (MenSCs) outside the uterus. MenSCs from endometriosis patients (E-MenSCs) and healthy women have been shown to vary i...

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We evaluated the potential mechanisms responsible for inducing beta-cell decline during the progression of obesity to type 2 diabetes mellitus (T2DM). Between February 2021 and February 2022, 25 subjects with non-diabetic obesity, 20 subjects with obesity and new-onset T2DM, and 25 healthy volunteer...

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Objectives: The purpose of this retrospective study is to compare dentigerous cysts and odontogenic keratocysts for cytoplasmic activation/proliferation - associated protein-1 antibodies via immunohistochemical staining to obtain a new perspective about the specific behavioural characteristics of od...

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