Search Results - "autophagy"

Background Ischemic preconditioning (IPC) protects the heart from prolonged ischemic insult and reperfusion injury through a poorly understood mechanism. Post‐translational modifications of histone residues can confer rapid and drastic switches in gene expression in response to various stimuli, incl...

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Autophagy-dependent cell death (ADCD) presents a promising but challenging therapeutic strategy in cancer treatment. Autophagy regulates cellular breakdown and stress responses, serving a dual function—either inhibiting tumorigenesis or facilitating the survival of cancer cells in advanced stages. T...

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Neuronal health depends on quality control functions of autophagy, but mechanisms regulating neuronal autophagy are poorly understood. Previously, we showed that in Drosophila starvation-independent quality control autophagy is regulated by acinus (acn) and the Cdk5-dependent phosphorylation of its...

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Pericarditis is a group of polyetiological diseases often associated with emergence of life–threatening conditions. Poor knowledge of underlying cellular mechanisms and lack of relevant approaches to investigation of pericarditis result in major challenges in diagnosis and treatment.The aim of this...

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Autophagy is a dynamic cellular process involved in the turnover of proteins, protein complexes, and organelles through lysosomal degradation. It is particularly important in neurons, which do not have a proliferative option for cellular repair. Autophagy has been shown to be suppressed in the stria...

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Background and purpose: Melanoma is a highly invasive malignant tumor originating from melanocytes, which poses a great threat to human life and health around the world, and its morbidity and mortality have been rising continuously in recent years. Telomerase and autophagy play crucial roles in cell...

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Background: Dermal white adipose tissue (dWAT) plays a crucial role in maintaining skin structure and functional homeostasis. Dysfunction of dWAT is closely associated with skin aging and fibrosis, with the impairment of autophagy and mitophagy considered the key mechanisms underlying adipose tissue...

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Background. Autophagy refers to an evolutionary physiological mechanism of cell self-purification. The use of its positive effects in regenerative and preventive medicine implies this process to be investigated under the conditions of various therapeutic factors.Objective. To investigate the influen...

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Introduction: Autophagy is a process that cells use to eliminate old, unused, and damaged cytoplasmic components. The interaction between autophagy and cytokines could be one of the mechanisms that coordinate the activity of the innate and adaptive immune systems. Depending on the cell type and acti...

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Culinary traditions define categories whether social or ontological. Food and its preparation are thus differentiating signs or markers of otherness. Depending on the context of preparation and consumption a basic and rude distinction can be drawn between daily and ritual food; in other words, situa...

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Ubiquitination serves as a dynamic post-translational modification that enables rapid and precise regulation of cellular signaling networks. TRIM21, as an important member of the TRIM family, is a protein with E3 ubiquitin ligase activity. By specifically recognizing and ubiquitinating various subst...

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Autophagy is a cell self-eating process that allows the orderly degradation and recycling of misfolded proteins and damaged organelles through lysosome. It plays a vital role in cells' adaptation to metabolic stress and homeostasis as well as the formation, development and treatment of tumors....

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Na Li,1– 3,* Qi Chen,2,3,* Yi Feng,2,3 Yin Wang2 1Silk Crossing Clinic, Affiliated Hospital of North Sichuan Medical College, Nanchong, People’s Republic of China; 2School of Stomatology, North Sichuan Medical College, Nanchong, People’s Republic of China; 3Medical Imaging Ke...

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Osteoporosis (OP) is a serious public health issue, and fragility fractures resulting from OP are a major cause of death in the elderly. Osteoblast (OB)-mediated insufficient bone formation and osteoclast (OCs)mediated abnormalities in bone destruction can result in OP. Autophagy is the process by w...

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Liver transplantation faces significant challenges, primarily due to the severe shortage of organs—aggravated by the increasing prevalence of liver diseases—and graft loss due to the consequences of ischemia/reperfusion injury (I/RI) and rejection. A recent study highlights the critical role of auto...

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Brain health is increasingly recognized as a critical component of overall wellbeing, particularly concerning neurodegenerative diseases, which are characterized by the progressive degeneration of the nervous system. Conditions such as Alzheimer’s disease (AD) and Parkinson’s disease, together with...

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Colorectal cancer (CRC) is a major global health concern, particularly in Western countries where there is high consumption of processed food. Gut microbiota, intestinal inflammation, and autophagy play pivotal roles in CRC initiation and progression. Probiotics and probiotic metabolites (particular...

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To explore the regulatory mechanism of the natural compound macelignan on apoptosis and autophagy in hippocampal neurons, this study investigated the effect of macelignan on the survival rate of HT22 cell line under glutamate-induced oxidative stress. Morphological changes and apoptosis were assesse...

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Background: Neoadjuvant PD-1 blockade may incidentally modulate autophagy in immune cells, which could contribute to drug resistance and tumor relapse. However, the specific immune cell subsets affected by neoadjuvant PD-1 blockade in terms of autophagy remain to be fully elucidated, as well as the...

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In normal tissue, cellular homeostasis is largely driven by two catabolic pathways: apoptosis and autophagy. Apoptosis, or programmed cell death, is regulated by pro-apoptotic factors, and promotes the removal of problematic cells. Autophagy, which in turn includes three forms: macro-, micro-, and c...

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