Search Results - "autoimmunity"

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  1. 1
    RELAPSING POLYCHONDRITIS IN RHEUMATOLOGY PRACTICE

    RELAPSING POLYCHONDRITIS IN RHEUMATOLOGY PRACTICE by N. P. Shilkina, I. V. Masina, S. Yu. Osipova, A. V. Klokov

    Published 2018-05-01

    The paper provides a clinical description of relapsing polychondritis, a rare systemic immunoinflammatory disease that was characterized by fever episodes, cartilage damage, and reactive arthritis. Diagnostic searching could rule out an infectious disease (by determining a wide variety of potential...

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  2. 2
    HLA DRB1* ASSOCIATION WITH REPRODUCTIVE DISORDERS IN WOMEN

    HLA DRB1* ASSOCIATION WITH REPRODUCTIVE DISORDERS IN WOMEN by L. A. Gordeeva, A. V. Shabaldin, A. N. Glushkov, O. A. Glushkova, O. S. Makarchenko, T. A. Simonova, I. V. Vetrova, E. A. Sherina, N. K. Zhilinskaya, V. I. Minina

    Published 2014-07-01

    Abstract. HLA DRB1* gene associations with idiopathic fetal losses and infertility were studied in women. It was shown that idiopathic fetal losses are associated with HLA DRB1*04 specificity, whereas infertility correlated with HLA DRB1*04/07 genotype. The associations revealed may indicate to a sp...

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  3. 3
    DNA-abzymes in autoimmune diseases in clinic and experiment

    DNA-abzymes in autoimmune diseases in clinic and experiment by T E Naumova, O M Durova, A G Gabibov, Z S Alelcberova, S V Suchkov

    Published 2003-02-01

    DNA-abzymes enzymes in autoimmune diseases in clinic and experiment T.E. Naumova, O.M. Durova, A.G. Gabibov, Z.S. Alekberova, S. V. Suchkov DNA-hydrolyzing autoantibodies (AAB) or DNA-abzymes can be found in autoimmune diseases in clinic and experiment. Technology of serum express screening for pres...

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  4. 4
    An Unusual Case of Multifactorial Hemolytic Anemia: A Complex Interaction Between Genetic and Autoimmune Factors

    An Unusual Case of Multifactorial Hemolytic Anemia: A Complex Interaction Between Genetic and Autoimmune Factors by Mario Biglietto, Giusy Peluso, Cristina Luise, Diletta Tripi, Maria Francesca Conforti, Valeria Filipponi, Luisa Bizzoni, Stefania Trasarti

    Published 2025-05-01

    Hemolytic anemias (HAs) encompasses a heterogeneous group of disorders with either congenital or acquired etiologies. We present a complex case of a 27-year-old woman with hemolytic anemia of multifactorial origin, involving both inherited RBC membrane defects and multiple autoimmune comorbidities....

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  5. 5
    A Scoping Review on the Prevalence of Hashimoto’s Thyroiditis and the Possible Associated Factors

    A Scoping Review on the Prevalence of Hashimoto’s Thyroiditis and the Possible Associated Factors by Hernando Vargas-Uricoechea, Alejandro Castellanos-Pinedo, Karen Urrego-Noguera, María V. Pinzón-Fernández, Ivonne A. Meza-Cabrera, Hernando Vargas-Sierra

    Published 2025-04-01

    Background: Hashimoto’s thyroiditis (HT) is the most common autoimmune thyroid disease (AITD) and is characterized by the presence of thyroid autoantibodies against thyroid peroxidase and/or thyroglobulin. Several studies have found that the global prevalence of HT has increased in recent decades, w...

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  6. 6
    MAST CELLS ARE KEY PARTICIPANTS IN THE PATHOGENESIS OF IMMUNOINFLAMMATORY DISEASES

    MAST CELLS ARE KEY PARTICIPANTS IN THE PATHOGENESIS OF IMMUNOINFLAMMATORY DISEASES by E. O. Baglay, A. I. Dubikov

    Published 2015-04-01

    Mast cells are an integral component of the pathogenetic  chain of immune inflammation in the body's tissues in different diseases. The mechanisms  underlying the proinflammatory effects of mast cells remain inadequately investigated. Their study may contribute to the optimization of therapy fo...

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  7. 7
    Autoimmune Gastritis Accompanied by a Schwannoma Presenting as a Subepithelial Tumor

    Autoimmune Gastritis Accompanied by a Schwannoma Presenting as a Subepithelial Tumor by Yong Hwan Ahn, Kyo Bum Hwang, Geom Seog Seo

    Published 2023-06-01

    Autoimmune gastritis (AIG), a chronic inflammatory disease occurs as a result of a complex interaction between host-related and environmental factors. AIG may progress to severe atrophic gastritis secondary autoimmune-mediated parietal cell destruction in the stomach. AIG can be diagnosed based on a...

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  8. 8
    Iodine Intake from Universal Salt Iodization Programs and Hashimoto’s Thyroiditis: A Systematic Review

    Iodine Intake from Universal Salt Iodization Programs and Hashimoto’s Thyroiditis: A Systematic Review by Hernando Vargas-Uricoechea, Alejandro Castellanos-Pinedo, Ivonne A. Meza-Cabrera, María V. Pinzón-Fernández, Karen Urrego-Noguera, Hernando Vargas-Sierra

    Published 2025-05-01

    Background: Hashimoto’s thyroiditis (HT) is characterized by the loss of tolerance to thyroid autoantigens [thyroid peroxidase (TPO) and thyroglobulin (Tg)], usually identifying circulating antibodies (Abs) against these thyroid autoantigens (TPOAb and/or TgAb), together with a significant lymphocyt...

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  9. 9
    An Exceedingly Rare Case of Mechanobullous Epidermolysis Bullosa Acquisita in a Prepubertal Child: A Review of the Clinical and Laboratory Considerations

    An Exceedingly Rare Case of Mechanobullous Epidermolysis Bullosa Acquisita in a Prepubertal Child: A Review of the Clinical and Laboratory Considerations by Aleksandra Wiktoria Bratborska, Maciej Spałek, Monika Bowszyc-Dmochowska, Marian Dmochowski

    Published 2025-04-01

    Introduction: Epidermolysis bullosa acquisita (EBA) is a rare autoimmune disease causing subepithelial blistering due to autoantibodies against type VII collagen. While mechanobullous EBA predominantly affects adults, our report presents an exceedingly rare case in an 11-year-old football player. Ca...

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  10. 10
    SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES

    SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES by V. A. Kozlov

    Published 2016-04-01

    The issues of immune pathogenesis in autoimmune pathology are discussed in this review. The main attention is drawn to potential pathogenetic role of various suppressor cell populations, including T-regulatory cells, mesenchymal stem cells, myeloid lineage-derived suppressors. Homeostatic lymphocyte...

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  11. 11
    SUBPOPULATIONAL FEATURES OF PERIPHERAL BLOOD CELLS IN THE PATIENTS WITH AUTOIMMUNE MYOCARDITIS: CLINICAL AND PATHOGENETIC ASPECTS

    SUBPOPULATIONAL FEATURES OF PERIPHERAL BLOOD CELLS IN THE PATIENTS WITH AUTOIMMUNE MYOCARDITIS: CLINICAL AND PATHOGENETIC ASPECTS by N. N. Kekenadze, Z. S. Shogenov, E. V. Kalinina, O. A. Pronina, B. V. Pinegin, M. A. Zemtsova, T. Elbeik, K. A. Maltsev, N. V. Gnuchev, S. V. Suchkov

    Published 2014-07-01

    Abstract. The goal of our research was comparative study of the most important parameters of subset cytoarchitectonics in the patients with the different courses of myocarditis and evaluation of their pathogenetic and clinical value in the practice of the physician. We have investigated 99 patients...

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  12. 12
    Pathophysiology in Systemic Sclerosis: Current Insights and Future Perspectives

    Pathophysiology in Systemic Sclerosis: Current Insights and Future Perspectives by Suzan Al-Gburi, Pia Moinzadeh, Thomas Krieg

    Published 2025-05-01

    <b>Background:</b> Systemic sclerosis (SSc) is a rare connective tissue disease characterized by vasculopathy, autoimmunity, and fibrosis. Due to its low prevalence and heterogeneous clinical presentation, early diagnosis remains challenging, often delaying appropriate treatment. The dis...

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  13. 13
    Demographic and Clinical Characteristics of Childhood Autoimmune Thyroiditis: Single-Center Study

    Demographic and Clinical Characteristics of Childhood Autoimmune Thyroiditis: Single-Center Study by Esmer Yıldırım, İhsan Esen, Deniz Ökdemir

    Published 2025-06-01

    Aim: This study aimed to evaluate the clinical characteristics of pediatric patients diagnosed with autoimmune thyroiditis (AIT) at a tertiary healthcare center. Materials and Methods: We conducted a retrospective study of 155 children diagnosed with AIT at a pediatric endocrinology clinic between...

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  14. 14
    Alteration of Metabolic Profile in Patients with Narcolepsy Type 1

    Alteration of Metabolic Profile in Patients with Narcolepsy Type 1 by Md Abdul Hakim, Waziha Purba, Akeem Sanni, Md Mostofa Al Amin Bhuiyan, Farid Talih, Giuseppe Lanza, Firas Kobeissy, Giuseppe Plazzi, Fabio Pizza, Raffaele Ferri, Yehia Mechref

    Published 2025-06-01

    <b>Background:</b> Narcolepsy type 1 (NT1) is a rare neurological sleep disorder characterized by excessive daytime sleepiness and cataplexy. NT1 is thought to be caused by the loss of hypocretin-producing neurons in the hypothalamus due to autoimmunity. Since cerebrospinal fluid hypocre...

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  15. 15
    Acute neuronal cell death and neuroinflammation per se do not trigger secondary autoimmune encephalitis in mice

    Acute neuronal cell death and neuroinflammation per se do not trigger secondary autoimmune encephalitis in mice by Justus Wilke, Antonios Ntolkeras, Vinicius Daguano Gastaldi, Kathrin Borowski, Bianca Teegen, Winfried Stöcker, Fred Lühder, Klaus-Armin Nave, Hannelore Ehrenreich

    Published 2025-06-01

    Abstract Patients with virus encephalitis, such as herpes simplex encephalitis and Japanese encephalitis frequently relapse with autoimmune encephalitides associated with neural autoantibodies. It has been hypothesized that the infection-induced damage to the central nervous system results in sheddi...

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  16. 16
    Demographic Characteristics and Inflammatory Biomarker Profile in Psoriatic Arthritis Patients with Comorbid Fibromyalgia: A Cross-Sectional Study

    Demographic Characteristics and Inflammatory Biomarker Profile in Psoriatic Arthritis Patients with Comorbid Fibromyalgia: A Cross-Sectional Study by Marino Paroli, Chiara Gioia, Daniele Accapezzato, Rosalba Caccavale

    Published 2025-06-01

    <i>Background and Objectives:</i> Psoriatic arthritis (PsA) is a chronic rheumatic disease that is frequently associated with fibromyalgia (FM). The coexistence of FM complicates the evaluation of PsA disease activity and the planning of treatment strategies, as the two conditions share...

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  17. 17
    Mitochondrial DNA copy number in monocytes and peripheral blood in patients with systemic sclerosis

    Mitochondrial DNA copy number in monocytes and peripheral blood in patients with systemic sclerosis by E. V. Gerasimova, A. I. Bogatyreva, T. V. Popkova, D. A. Gerasimova

    Published 2024-07-01

    Innate immune cells are important participants in inflammatory and fibrotic processes in systemic scleroderma (SSc). The pathogenesis of SSc involves immune cells, primarily macrophages, whose disorders are based on mitochondrial cell dysfunction. Mitochondrial DNA (mtDNA) copy number is used as a s...

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  18. 18
    Autoimmune manifestations in children with inborn errors of immunity in Morocco: A study from the national registry

    Autoimmune manifestations in children with inborn errors of immunity in Morocco: A study from the national registry by Ahamada Elamine, Ibtihal Benhsaien, Fatima Ailal, Abderrahmane Errami, Zakaria Kasmi, Zahra Aadam, Asmaa Drissi Bourhanbour, Ahmed Aziz Bousfiha, Jalila El Bakkouri

    Published 2025-12-01

    Inborn Errors of Immunity (IEI) are a heterogeneous group of genetic disorders characterized by increased susceptibility to infections and immune dysregulation, including autoimmunity and autoinflammation. Despite their clinical significance, data on autoimmune manifestations in Moroccan pediatric p...

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  19. 19
    Persistent symptoms in euthyroid Hashimoto’s thyroiditis: current hypotheses and emerging management strategies

    Persistent symptoms in euthyroid Hashimoto’s thyroiditis: current hypotheses and emerging management strategies by Hui Zhang, Hui Zhang, Wenting Tong, Weiyong Zeng, Hongyan Luo, Licai Zhang, Jiasheng Feng, Yang Xiao, Gankun Wang

    Published 2025-07-01

    A substantial proportion of patients with Hashimoto’s thyroiditis (HT) continue to experience persistent symptoms despite achieving biochemical euthyroidism, either with or without levothyroxine (LT4) replacement therapy. Several pathophysiological mechanisms have been proposed to explain this clini...

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  20. 20
    Advanced immunophenotyping of lymphocyte and monocyte subsets in healthy Australian adults using a novel spectral flow cytometry panel

    Advanced immunophenotyping of lymphocyte and monocyte subsets in healthy Australian adults using a novel spectral flow cytometry panel by Ainsley R. Davies, Ainsley R. Davies, Kristy Kwong, Kristy Kwong, Kristy Kwong, Zhijia Yu, Koula E. M. Diamand, Koula E. M. Diamand, Fei-Ju Li, Fei-Ju Li, Laurensia Kannitha, Sidra A. Ali, Abolfazl Amjadipour, Ann-Maree Padarin, Michael Devoy, Harpreet Vohra, Bahar Miraghazadeh, Simon H. Jiang, Simon H. Jiang, Anne Brüstle, Nicolas Cherbuin, Christopher J. Nolan, Christopher J. Nolan, Matthew C. Cook, Elizabeth E. Gardiner, Stuart Read, Stuart Read, Euan McNaughton, Katrina L. Randall, Katrina L. Randall, Katrina L. Randall

    Published 2025-07-01

    IntroductionLymphocytes play pivotal roles in disease pathogenesis and can be used as potential biomarkers for various immunological conditions. Yet, current flow cytometry methods used in clinical settings are often only capable of measuring between four to eight distinct lymphocyte populations. Th...

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