Search Results - "atorvastatin"

Aim. To assess lipid-lowering effectiveness of generic atorvastatin in patients with various hyperlipidaemia (HLP) phenotypes in an open, short-term (four weeks) study.Material and methods. All participants were divided into two groups — with isolated hypercholesterolemia (HCH) and normal fasting tr...

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In this study, the simultaneous quantification of amlodipine and atorvastatin in pharmaceutical preparations was successfully accomplished without the need for a separation process by using chemometric calibration methods (principal component analysis method (PCA), principal component regression met...

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Recently, high effectiveness of long-term statin therapy has been demonstrated not only for hyperlipidemias, but also for various forms of coronary heart disease and high cardiovascular risk. Low therapy compliance restricts statins’ effectiveness substantially. Awareness of the factors determining...

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Aim. To study the Russian atorvastatin generic (Liptonorm) effects on lipid metabolism in patients with coronary heart disease (CHD), essential arterial hypertension (EAH), and high risk of cardiovascular complications (CVC). Material and methods. In total, 30 patients (17 men, 13 women; mean age 52...

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The evidence base of statin therapy in primary and secondary prevention of ischemic stroke is surveyed. Results of classical trails with statins in ischemic stroke prevention as well as results of meta-analyses are discussed.

The article is devoted to modern approaches to lipid-lowering therapy. The role of statins in primary and secondary prevention of atherosclerotic pathology is described. The author presents modern views on the choice of the statin dose optimal for maximal preventive cardiovascular effect.

The article reviews the current evidence on reducing the risk of cardiovascular events and death in acute coronary syndrome patients (ACS) by early administration of statins. The results of the latest meta-analyses and official clinical recommendations are discussed. The statin with the strongest ev...

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The evidences for statin use in cardiology are presented. Especially hypolipidemic efficacy of atorvastatin is demonstrated in according to comparative studies. Results of clinical studies on atorvastatin efficacy and safety in different groups of patients are also presented.

Aim. To perform an additional assessment of cardiovascular risk (CVR) levels in patients with low and moderate risk by SCORE scale (European Society of Hypertension/European Society of Cardiology, 2003, 2007), in order to identify the individuals with high CVR; to study the effectiveness of Liptonor...

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Aim. To investigate low density lipoprotein cholesterol (LDL-CH) lowering effectiveness of atorvastatin (Torvacard; 20 mg/d) in patients with moderate hypercholesterolemia (HCH) after 4 and 12 weeks of treatment, together with standard hypolipidemic diet; to assess (%) target LDL-CH level achievemen...

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Large epidemiological trails shown that hypercholesterolemia is one of the main risk factor of ischemic heart disease (IHD). Correction of the hypercholesterolemia with GmGKoA reductase inhibitors (statins) essentially reduces IHD morbidity and mortality. The lower serum level of low density lipopro...

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Objective: to study the time course of changes in serological inflammatory markers in patients with systemic scleroderma (SSD) on long-term statin treatment. Subjects and methods. The study covered 40 patients with SSD who were divided into a study group (n = 22) and a control one (n = 18). In the s...

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Aim. To study the effectiveness of long-term low-dose atorvastatin therapy in elderly patients with Type 2 diabetes mellitus (DM-2) and dyslipidemia (DLP). Material and methods. In total, 135 elderly patients with DM-2 and DLP were included in the main group (MG), receiving atorvastatin (10—20 mg/d;...

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The aim of this study was to assess effects of the eight-week course of atorvastatin therapy upon the levels of spontaneous cytokine production by mononuclear blood leukocytes (MNBC) in metabolic syndrome. An open-label prospective study included 36 patients with stage II hypertension (blood pressur...

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Rhabdomyolysis is a very rare and most severe form of statin-induced muscle adverse event characterized by muscle pain, muscle necrosis with myoglobinemia and/or myoglobinuria with a very high risk of acute kidney injury and death. The article presents a case report of developing rhabdomyolysis in a...

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Background. Dyslipidemia is one of the most serious modifiable risk factors for acute coronary  syndrome which is the most leading cause of mortality and morbidity worldwide.Aim. To assess the short-term safety and efficacy of full dose rosuvastatin and atorvastatin in patients with acute coronary ...

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The paper reviews recent studies justifying high-dose statin therapy (in particular, atorvastatin treatment) in patients with coronary heart disease (CHD) and high risk of life-threatening coronary events. In the latest placebo- controlled and comparative studies of high statin doses (e.g., 80 mg/d...

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BackgroundInclisiran is an siRNA-based cholesterol-lowering drug with N-acetylgalactosamine carbohydrate (GalNAc) and is used for the treatment of hypercholesterolemia or dyslipidemia. It reduces LDL-C by 50%, with a convenient dosing schedule and fewer adverse events. Unlike statins, inclisiran has...

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The review focuses on clinical trials data demonstrating a possibility of effective statin therapy of acute and chronic ischemic heart disease courses. The analysis of maximal dosages of atorvastatin application provided, its early prescription in first 24-96 hours after acute cardiovascular event a...

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Background: Breast cancer is currently the most prevalent malignancy among females, representing a substantial threat to both physical and psychological health. Moreover, its incidence rate continues to rise annually. Therefore, screening potential therapeutic targets and developi...

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