検索結果 - "atopic dermatitis"

Atopic  dermatitis (AD) significantly reduces the quality of life of patients. Skin lesions, itching, and sleep dysfunction lead to impaired social adaptation and work performance.Systemic immunosuppressants are used for  the treatment of  severe AD.  The use of  antihistamines and  antileukotrienes...

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Dupilumab is a genetically engineered immunobiological drug that has been increasingly used in recent years to treat bronchial asthma (BA), atopic dermatitis (AD) and eosinophilic esophagitis (EE) in children. The aim of the study is to analyze current literature data on the use of dupilumab in the...

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Background. Atopic dermatitis (AD) is a chronic inflammatory skin disease with such clinical manifestations as eczematous lesions and itching. One of its clinical forms is palmoplantar eczema. It is urgent and unresolved issue in pediatric dermatology as this disease significantly affect the patient...

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Pruritus is one of the main clinical manifestations of atopic dermatitis, and it significantly reduces the quality of life of patients in childhood. Scientific images on its pathophysiological basis have now undergone significant changes. The histamine exceptional role in pruritus development was co...

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Background Dupilumab has revolutionized treatment of moderate-to-severe atopic dermatitis (AD). However, its use has been associated with ophthalmologic adverse events referred to as dupilumab-associated ocular surface disease (DAOSD), reported in up to 30% of patients. Although several risk factors...

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In accordance with Clinical Guidelines of the Russian Society of Dermatovenerologists and Cosmetologists, atopic dermatitis is a chronic allergic genetically determined dermatosis of a multifactorial nature. There are, however, some aspects that challenge the allergic nature of dermatosis. For examp...

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Wiskott — Aldrich syndrome (WAS) is a rare, X-linked combined disease with immunodeficiency caused by mutations in the WAS gene that encodes the WAS protein (WASp). Manifestations range from a relatively mild form of the disease (intermittent X-linked thrombocytopenia), characterized by thrombocytop...

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Aim: to assess safety of moistening lotion in atopic dermatitis in children and their attitude toward basis skin care with the abovementioned drug. Patients and methods: 446 children aged from 14 days to 18 years old were included into the study, among them 222 (48%) girls and 244 (52%) boys; 271 (5...

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In the article, vitiligo appears as a chronic multifactorial disease of the skin of unclear etiology from the group of dyschromias with completely different mechanisms of its pathogenesis and levels of malignant melanin formation in the skin. The authors provide their own clinical observations of pa...

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Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. Early management of AD is crucial for preventing the development of atopic disease such as asthma, allergic rhinitis, etc. Topical glucocorticoids (TGCs) are used as first-line therapy, however, their long-term use poses th...

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Background. Netherton syndrome is a severe autosomal recessive disease based not only on genetically determined keratinization disorders, but also on immune system dysregulation.Clinical case description. Boy K., 9 years old, diagnosed with severe atopic dermatitis and revealed Netherton syndrome du...

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The lack of a validated Chinese version of the Recap of Atopic Eczema questionnaire (RECAP) questionnaire limits its applicability. This prospective study, conducted at a Chinese tertiary hospital between April and November 2024, aimed to evaluate measurement properties of the Chinese RECAP. Partici...

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Background/objectivesRecent studies have sought to determine the correlation between atopic dermatitis (AD) and the occurrence of stroke; however, these investigations have not reached a consensus. Consequently, our team conducted this meta-analysis and systematic review to further explore the poten...

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Local glucocorticoids (GCs) are the gold standard of anti-inflammatory topical therapy. The description of the main pharmaceutics properties and classification of local GCs, as well as its indications and contradictions are presented in the article. This article also provides fundamentals for applic...

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The review presents modern data on the pathogenic role of CC chemokine is CX3CL1 or fractalkine in the cascade of immune responses in various diseases. The material presented sistematizirovat the most significant results of the work of clinical diagnostic value fractalkine in pathological conditions...

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Skin is the natural habitat for complex bacterial, fungal, and viral communities (ecosystems). The microbiome of such communities is always in close relationship with the host genome, and the development of these ecosystems happens under the effects of morpho-physiological and immunological characte...

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The skin microbiome plays a crucial role in the pathogenesis of atopic dermatitis (AD), a chronic inflammatory skin disorder strongly associated with microbial dysbiosis, particularly Staphylococcus aureus colonization. However, the mechanisms linking S aureus to AD remain insufficiently understood....

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Atopic dermatitis (AD) is commonly linked to the recurrent occurrence of bilateral allergic conjunctival inflammation, known as vernal keratoconjunctivitis (VKC). Very rarely VKC can lead to limbal stem cell deficiency which may cause permanent vision loss. This case report details a 9-year-old boy...

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The drugs and phytoaromatic substances increases the efficacy of balneotherapy. Mineral, medicinal and aromatic baths are widely used in complex rehabilitation of patients from 1 month of age. Aromatic phyto-baths have a complex mechanism of action and a wide variety of therapeutic effects. Today sp...

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This paper presents an analysis of children suffering from bronchial asthma (BA) and atopic dermatitis (AD) of the frequency visits to the allergological hospital in Rostov-on-Don for 2017–2019.Results. It was found that patients with BA (75.33%) required the most frequent hospital admissions compar...

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