Search Results - "atherothrombosis"

Current issues of atherothrombosis prevention and treatment optimization with antiplatelet therapy in patients with cardioascular diseases are discussed. Role of clopidogrel in contemporary antiplatelet therapy is focused on, especially in the aspect of the problem of aspirin resistance. Chronology...

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The results of large-scale clinical trials have convincingly demonstrated the effectiveness of acetylsalicylic acid (ASA) in primary and secondary prevention of atherothrombotic events. Studies on the safety of different ASA formulations have been continuing. Magnesium hydroxide included in combined...

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On the basis of historical documents, memoirs of contemporaries, the authors analyze the clinic and development of atherothrombosis the left femoral artery complicated by gangrene of the limb from which sufferd the well-known historical figures — the king of France Louis XIV. The authors clarify the...

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Aim. To identify the factors determining homocysteine (HMC) levels in Russian patients with stable coronary heart disease (CHD). Material and methods. The study included 506 patients (388 men; mean age 59,4±12,2 years) with stable CHD. Classical risk factors (RFs) of cardiovascular disease (CVD), re...

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One of the most effective platelet antiaggregants is clopidogrel, inhibiting platelet activation by selectively binding adenosine diphosphate (ADP) with specific receptors. However, in a number of clinical situations it is necessary to have a pronounced antithrombotic effect in the shortest possible...

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According to the results of prospective studies performed at the State Research Center for Preventive Medicine, the data on main cardiovascular risk factors prevalence, their role in total cardiovascular mortality, coronary heart disease and stroke mortality in Russian population are presented. It i...

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This review is focused on the main aspects of aspirin therapy in the prevention of various atherothrombosis manifestations and coronary heart disease (CVD). The major mechanism of aspirin action is explained, and additional aspirin benefits, unrelated to its anti-aggregant activity, are described. C...

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Atherosclerosis is one of the most urgent problems in modern cardiology. Atherosclerosis instability and coronary heart disease clinical course are based on plaque ulceration, rupture, and atherothrombosis. Atherothrombosis causes 28% of all deaths worldwide. Therefore, usage of medications targeted...

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Aim. To study the associations between polymorphic variants of hemostasis protein-coding genes, hemostasis system functioning, and atherothrombosis development in patients with cardiovascular disease (CVD). Material and methods. The study included 76 patients. Polymorphic gene marker alleles were an...

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Modern views of stroke prevention are discussed. Universally recognized strategies of stroke prevention are analyzed and new approaches to preventive treatment of cerebral circulation disorders are proposed.

Inflammatory mediators play an important role in the pathogenesis of acute coronary syndrome (ACS). The results of experimental and randomized clinical trials on the role of various inflammation inhibitors in the treatment of coronary artery disease (CAD), in particular CANTOS and COLCOT, mark a new...

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Arterial hypertension (HT) is a reason for raising a question about need for antithrombotic therapy. At the same time, increased blood pressure associated with an increased risk of hemorrhagic complications. Possible ways to minimize the hemorrhagic risk in different groups of hypertensive patients...

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Lipoprotein(a) (Lp(a)) is a complex supramolecular complex belonging to apoB100 lipoproteins. Lp(a) consists of a particle of similar low-density lipoprotein, in which the apolipoprotein molecule В100 is covalently linked by a disulfide bond with a unique polymorphic apolipoprotein(a) molecule. The...

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Aim. To study the association of plasma D-dimer levels and the risk of thrombotic events in patients hospitalised with acute coronary syndrome (ACS).Material and methods. The study included 70 patients, aged 34-88 years, who were admitted to the Acute Coronary Care Unit with the ACS diagnosis.Result...

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Article takes into consideration pathogenetic mechanisms of cardiovascular diseases development  in obesity and insulin resistance, approaches to atherothrombotic complications prevention. The issues of resistance to antiplatelet drugs  are condsidered and possible  ways for its overcome.  The data ...

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The course and complications of coronary artery disease (CAD) are associated with atherosclerosis progression and a high probability of atherothrombosis. Antithrombotic therapy is the most effective strategy for preventing cardiovascular events in atherosclerotic diseases. In accordance with current...

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Atherothrombosis is a complication of ischemic heart disease, and it leads to development of acute coronary syndrome. Atherothrombosis is characterized by sudden destruction of atherosclerotic plaque, which results into platelets activation and thrombus formation. Aspirin - one of the most widely us...

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Aim. To analyze the literary and own data about clopidogrel influence on platelets during inflammation and to reveal particularities of its usage in ischemic heart disease (IHD) patients with active inflammation. Material and methods. The platelet morphology and a number of leukocyte-platelet aggreg...

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Aim. To study the intensity of the intravascular microcoagulation in patients with atherothrombosis (AT), chronic obstructive pulmonary disease (COPD) and thrombophilia.Material and methods. 115 patients were enrolled into the study: 37 patients with COPD (22 with thrombophilia and 15 without thromb...

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Patients with coronary artery disease (CAD) and diabetes are identified as a high cardiovascular risk group both in Russia and abroad. Having similar paths of development and progression of atherosclerosis and atherothrombosis, these diseases potentiate each other's thrombogenesis mechanisms. A...

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