Search Results - "arenavirus"

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  1. 1
    Characterization of a STAT-1 Knockout Mouse Model for Machupo Virus Infection and Pathogenesis

    Characterization of a STAT-1 Knockout Mouse Model for Machupo Virus Infection and Pathogenesis by Stephanie R. Monticelli, Ana I. Kuehne, Russell R. Bakken, Susan R. Coyne, Kenise D. Lewis, Jo Lynne W. Raymond, Xiankun Zeng, Joshua B. Richardson, Zebulon Lapoint, Jennifer L. Williams, Christopher P. Stefan, Jeffrey R. Kugelman, Jeffrey W. Koehler, Andrew S. Herbert

    Published 2025-07-01

    Machupo virus (MACV), a member of the <i>Arenaviridae</i> family and causative agent of Bolivian hemorrhagic fever, results in lethality rates of 25–35% in humans. Mice lacking the signal transducer and activator of transcription 1 (STAT-1<sup>−/−</sup>) have previously been...

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  2. 2
    Structure and stabilization of the antigenic glycoprotein building blocks of the New World mammarenavirus spike complex

    Structure and stabilization of the antigenic glycoprotein building blocks of the New World mammarenavirus spike complex by Guido C. Paesen, Weng M. Ng, Simon Kimuda, Geoff Sutton, Katie J. Doores, Thomas A. Bowden

    Published 2025-07-01

    ABSTRACT The spillover of New World (NW) arenaviruses from rodent reservoirs into human populations poses a continued risk to human health. NW arenaviruses present a glycoprotein (GP) complex on the envelope surface of the virion, which orchestrates host cell entry and is a key target of the immune...

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  3. 3
    Progress toward the development of Lassa vaccines

    Progress toward the development of Lassa vaccines by Hinh Ly

    Published 2024-12-01 Subjects: Get full text
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  4. 4
    Recent Discoveries of Novel Mammarenaviruses Infecting Humans and Other Mammals in Asia and Southeast Asia

    Recent Discoveries of Novel Mammarenaviruses Infecting Humans and Other Mammals in Asia and Southeast Asia by Brigitte Flannery, Michaela Cain, Hinh Ly

    Published 2023-12-01

    Mammarenaviruses, a genus of the family Arenaviridae, are capable of infecting mammals and are primarily found in rodent reservoirs worldwide. Mammarenaviruses can be transmitted to humans through contact with infected rodents, and though infection is often asymptomatic, some members of this genus c...

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  5. 5
    N6-methyladenosine is required for efficient RNA synthesis of Ebola virus and other haemorrhagic fever viruses

    N6-methyladenosine is required for efficient RNA synthesis of Ebola virus and other haemorrhagic fever viruses by Lisa Wendt, Matthew J. Pickin, Bianca S. Bodmer, Sven Reiche, Lucie Fénéant, Julia E. Hölper, Walter Fuchs, Allison Groseth, Thomas Hoenen

    Published 2023-12-01

    N6-methyladenosine (m6A) is one of the most abundant modifications of cellular RNA, where it serves various functions. m6A methylation of many viral RNA species has also been described; however, little is known about the m6A epitranscriptome of haemorrhagic fever-causing viruses like Ebola virus (EB...

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  6. 6
    Animal Models of Pathogenic New World Arenaviruses

    Animal Models of Pathogenic New World Arenaviruses by Alexander V. Alvarado, Robert W. Cross, Thomas W. Geisbert, Courtney Woolsey

    Published 2025-06-01

    Since the emergence of Junín virus in 1953, pathogenic New World arenaviruses have remained a public health concern. These viruses, which also include Machupo virus, Guanarito virus, Sabiá virus, and Chapare virus, cause acute viral hemorrhagic fever and neurological complications, resulting in sign...

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  7. 7
    The Hidden Threat: Rodent-Borne Viruses and Their Impact on Public Health

    The Hidden Threat: Rodent-Borne Viruses and Their Impact on Public Health by Awad A. Shehata, Rokshana Parvin, Shadia Tasnim, Phelipe Magalhães Duarte, Alfonso J. Rodriguez-Morales, Shereen Basiouni

    Published 2025-06-01

    Rodents represent the most diverse order of mammals, comprising over 2200 species and nearly 42% of global mammalian biodiversity. They are major reservoirs of zoonotic pathogens, including viruses, bacteria, protozoa, and fungi, and are particularly effective at transmitting diseases, especially sy...

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  8. 8
    The Estimation of Efficacy of Nonspecific Medications Against Hemorrhagic Fevers Caused by Arenaviruses

    The Estimation of Efficacy of Nonspecific Medications Against Hemorrhagic Fevers Caused by Arenaviruses by Т. Е. Sizikova, V. N. Lebedev, S. V. Borisevich

    Published 2023-12-01

    The article presents an analysis of studies assessing the effectiveness of new nonspecific medications against hemorrhagic fevers caused by arenaviruses. The possible targets for nonspecific medications, classes of researched antiviral preparations, methods of preclinical investigation of antiviral...

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  9. 9
    MOLECULAR-BIOLOGICAL PECULIARITIES OF ARENAVIRUS REPRODUCTION IN SENSITIVE CELLS

    MOLECULAR-BIOLOGICAL PECULIARITIES OF ARENAVIRUS REPRODUCTION IN SENSITIVE CELLS by T. E. Sizikova, V. N. Lebedev, V. B. Pantyukhov, A. F. Andrus, S. V. Borisevich

    Published 2017-06-01

    The Arenaviridae family consists of a large group of single strand ambisense RNA viruses that are separated phylogenetically, serologically and geographically into Old World and New World viruses. Recent studies indicate that cellular entry of arenaviruses requires a series of cellular protein inter...

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  10. 10
    Validation of Сhoice of Laboratory Model for Preclinical Estimation of Medical Protectors Against Bolivian Hemorrhagic Fever

    Validation of Сhoice of Laboratory Model for Preclinical Estimation of Medical Protectors Against Bolivian Hemorrhagic Fever by T. E. Sizikova, V. N. Lebedev, V. B. Pantukhov, E. Y. Vakhnov, S. V. Borisevich

    Published 2023-07-01

    This review is dedicated to the peculiarities of pathogenesis of the experimental Bolivian hemorrhagic fever (BHF) - the disease, caused by Machupo virus (Arenaviridae family). The authors come to the conclusion that for carrying out preclinical researches of the medical means of protection (MMP) in...

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  11. 11
    Highly Effective xMAP Multiplex Assay for the Detection and Identification of Hemorrhagic Fever Agents, Including Ebola Virus

    Highly Effective xMAP Multiplex Assay for the Detection and Identification of Hemorrhagic Fever Agents, Including Ebola Virus by V. A. Ternovoy, A. V. Sementsova, E. V. Chub, O. V. P’Yankov, V. B. Loktev, A. P. Agafonov

    Published 2015-09-01

    Developed has been the oligonucleotide liquid biochip based on xMAP technology, designed for the laboratory detection of particularly dangerous viral pathogens such as Ebola and Marburg filoviruses, and Machupo , Junin, and Lassa arenaviruses. The suggested approach allows for the detection of up to...

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  12. 12
    The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers

    The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers by T. E. Sizikova, V. N. Lebedev, S. I. Syromyatnikova, S. V. Borisevich

    Published 2018-07-01

    Presently, the Arenavirus genus (Arenaviridae family) includes 26 individual species of viruses. It is divided into two main groups – Old World arenaviruses and New World arenaviruses. The New World arenaviruses comprise four clades: А, B, C, D; pathogenic for humans New World arenaviruses are attri...

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  13. 13
    Future Developments and Applications of the Vaccines against Dangerous Viral Infections, RNA-Replicon-Based, Obtained from the Venezuelan Equine Encephalomyelitis Virus

    Future Developments and Applications of the Vaccines against Dangerous Viral Infections, RNA-Replicon-Based, Obtained from the Venezuelan Equine Encephalomyelitis Virus by A. A. Petrov, V. N. Lebedev, T. M. Plekhanova, L. F. Stobva, O. N. Sidorova, E. V. Mel’Nikova, S. V. Borisevich

    Published 2014-09-01

    The members of the Filoviridae (Marburg and Ebola viruses) and Arenaviridae (Lassa, Lujo, Machupo, Junin, Guanarito, Sabia viruses) families are the etiological agents of particularly dangerous viral hemorrhagic fevers. These agents pose a potential threat to public health care in view of the possib...

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  14. 14
    The kit for identification of antibodies against Lassa and Ebola viruses by indirect immunofluorescence

    The kit for identification of antibodies against Lassa and Ebola viruses by indirect immunofluorescence by L. M. Rustamova, S. F. Semenov, N. L. Bogdanova, A. S. Vladyko, A. G. Krasko

    Published 2018-02-01

    Timely diagnosis of particularly dangerous infections caused by viruses Ebola and Lassa is crucial in organization of anti-epidemic measures in the case of important of the disease on the territory of the Republic of Belarus. The main method of rapid response at revealing hemorrhagic fevers Lassa an...

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