Search Results - "animal model"

Like many other pathological infectious processes, sepsis is mainly studied in vivo using mice models. Over the past 30 years, such studies have led to significant achievements in understanding of the sepsis pathophysiology. However, unfortunately, none of them led to any «discoveries» in the treatm...

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ABSTRACT Background Associating liver partition and portal vein ligation (PVL) for staged hepatectomy (ALPPS) and selective PV embolization (PVE) are important clinical strategies in liver surgery. Even though it has been demonstrated that ALPPS induces a more rapid and expressed hypertrophy than PV...

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<b>Background/Objectives:</b> Aging alters neutrophil functions, which may contribute to the progression and severity of periodontitis-related alveolar bone loss. Neutrophils play a key role in immune defense. However, the effects of aging on neutrophil functions and their contribution t...

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Background: Local delivery of hormones could potentially provide local benefits to bone and enthesis while avoiding systemic side effects. The objective of this study was to demonstrate proof of concept for local deposition of estradiol in a rat rotator cuff repair model. Methods: First, in vitro el...

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Pain phenomenon, the unpleasant sensory and emotional event, appears to evidently intrude in Parkinson disease (PD), a disease formally considered to be restricted only to motor deficits. Although over a half of persons with PD suffer from pain manifestations, there are very few reports targeting th...

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Parkinson’s disease (PD) is a progressive neurodegenerative disorder primarily characterized by motor impairments resulting from dopaminergic neuron degeneration in the substantia nigra. However, PD is increasingly recognized as a multisystem disorder, where non-motor symptoms such as cognitive impa...

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The objectives of this study were to estimate genetic parameters of lactation average somatic cell scores (LSCS) and examine genetic associations between LSCS and production traits in the first three lactations of Chinese Holstein cows using single-parity multi-trait animal model and multi-trait rep...

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Paracetamol is one of the five most common drugs causing fatal hepatotoxicity. The mouse model of paracetamol hepatotoxicity adequately reflects the mechanism of drug poisoning in humans. However, there are many controversies associated with understanding the pathogenetic mechanisms of process.   Ai...

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Dystonia is a neurologic disorder characterized by abnormal muscle contractions and postures, which is vastly heterogeneous in its etiologies and clinical manifestations. The role of the basal ganglia in the pathogenesis of dystonia is well known, however, there has been a recent surge of evidence i...

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The aim of the work was to study the features of the infectious process in the lungs of animals used as models for assessing SARS-CoV-2 pathogenicity.Materials and methods. The strain of SARS-CoV-2 alpha variant virus was used in the work. The experiments were carried out on linear and transgenic mi...

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IntroductionThis study aims to establish a simple and reproducible transvaginal mesh surgery rat model based on the modified pelvic organ prolapse rat model.MethodsA total of 24 10-week-old female nulliparous Wistar rats were used in this study. The control group consisted of six rats with no interv...

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Qiang Cai,1,* Gang Xu,2,* Junhui Liu,1 Long Wang,1 Gang Deng,1 Jun Liu,3 Zhibiao Chen1 1Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, 2Department of Neurosurgery, Xiantao First People&amp;rsquo;s Hospital, Xiantao, 3Department of Emergency, The Central Hospital of Wuha...

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BackgroundEvidence suggests that luteolin (LUT) may offer therapeutic potential in treating ulcerative colitis (UC), though its specific pharmacological mechanisms remain incompletely understood. This meta-analysis aims to assess the pharmacological effects of LUT in UC animal models and investigate...

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Aim. To test in experiment a pathogenetically adequate model of brain death due to increased intracranial pressure with gradual induction, allowing the evaluation of the changes occurring in the organs of a potential donor.Materials and methods. 6–8 months old outbred male rats of the experimental g...

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Autism spectrum disorder is a complex neurodevelopmental condition that poses major challenges to caregivers in contemporary societies. Since there is no established cure for this disorder so far, autistic patients of all ages are currently taken in charge of psychological and educational therapies...

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Peripheral nerve injuries (PNIs) commonly result from trauma, compression, or iatrogenic causes, leading to functional deficits. Despite the peripheral nervous system’s regenerative capacity, current treatments yield inconsistent outcomes. Basic science and translational research supporting nerve re...

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This study aimed to investigate the selection potential for early body mass in a layer resource population, and to compare three inference methods based on their efficiency and accuracy, including restricted maximum likelihood method (REML), Markov chain Monte Carlo method (MCMC), and integrated nes...

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ObjectiveThis review aims to study the characteristics of animal models of diabetic gastroparesis, provide a reference for the standardization of model preparation, and offer a better experimental basis for researching its pathogenesis and diagnosis-treatment strategies.MethodsBy searching databases...

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The evaluation of breeding value for economically important traits is a key tool in modern systems of genetic improvement in dairy cattle. This analytical study aimed to describe the current algorithm for genetic evaluation in dairy cattle and to identify promising directions for potential improveme...

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Hallucinations represent a transdiagnostic phenomenon observed in multiple neuropsychiatric disorders, including schizophrenia, substance use disorder and substance-induced psychotic conditions. Despite their clinical prevalence, objective assessment remains challenging due to its subjective nature,...

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