खोज परिणाम - "University of Pittsburgh"
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Artificial intelligence-based machine learning protocols enable quicker assessment of aortic biomechanics: A case study
प्रकाशित 2025-08-01पूर्ण पाठ प्राप्त करेंAnalyzing aortic biomechanical wall stresses for abdominal aortic aneurysms remains challenging. Clinical applications of biomechanical and morphological image-based analysis protocols have limited adoption owing to the time and expertise required. Our multidisciplinary and multi-institute team has...
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Case Report: A personalized model of care for surgical resection of complex brain tumor with atypical language dominance
प्रकाशित 2025-07-01पूर्ण पाठ प्राप्त करेंThe gold standard for preserving language and cognitive function during complex brain tumor resection is direct electrical stimulation (DES) during awake craniotomy. DES is predominantly utilized for left hemisphere (LH) tumors, where language dominance is most common. However, atypical language dom...
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The LATTICE Study: Design of a pilot feasibility randomized controlled trial of lithium to delay cognitive decline in mild cognitive impairment
प्रकाशित 2025-04-01पूर्ण पाठ प्राप्त करेंAbstract INTRODUCTION Interest has grown in lithium's neuroprotective properties in neurodegenerative illnesses. We discuss the design, rationale, and implementation of a pilot feasibility, double‐blind, randomized placebo‐controlled trial (RCT) examining whether lithium can delay cognitive dec...
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The Reliability and Validity of an Instrumented Device for Tracking the Shoulder Range of Motion
प्रकाशित 2025-06-01पूर्ण पाठ प्राप्त करेंRotator cuff tears are common in individuals over 40, and physical therapy is often prescribed post-surgery. However, access can be limited by cost, convenience, and insurance coverage. CuffLink is a telehealth rehabilitation system that integrates the Strengthening and Stabilization System mechanic...
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Small cuts, big questions: the impact of incision length in minimally invasive robotic cardiac surgery
प्रकाशित 2025-06-01पूर्ण पाठ प्राप्त करेंIntroductionEvidence on incision lengths for ports and cardiopulmonary bypass (CPB) cannulation in robotic cardiac surgery is limited. This study aimed to assess these metrics and influencing factors.Methods204 patients underwent robotic mitral valve repair (MVR) (54.9%), totally endoscopic coronary...
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Natural History of Tricuspid Regurgitation After Transcatheter Aortic Valve Implantation
प्रकाशित 2025-07-01पूर्ण पाठ प्राप्त करेंBackground To determine the impact of tricuspid regurgitation (TR) on outcomes after transcatheter aortic valve implantation (TAVI), and to determine the evolution of TR severity after TAVI. Methods This was an observational study of TAVIs for aortic stenosis from November 2012 to December 2021. Pat...
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Gray Matter Differences in Adolescent Psychiatric Inpatients: A Machine Learning Study of Bipolar Disorder and Other Psychopathologies
प्रकाशित 2025-06-01पूर्ण पाठ प्राप्त करेंAbstract Background Bipolar disorder (BD) is among the psychiatric disorders most prone to misdiagnosis, with both false positives and false negatives resulting in treatment delay. We employed a whole‐brain machine learning approach focusing on gray matter volumes (GMVs) to contribute to defining ob...
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Load transmission via the supraspinatus cord prevents muscle fatty degeneration, a biomechanical study
प्रकाशित 2025-07-01पूर्ण पाठ प्राप्त करेंBackground: Location of small- to medium-sized (<30 mm) rotator cuff tears can predict (supraspinatus [SS]) muscle fatty degeneration. It has been hypothesized that SS fatty degeneration occurs because of loss of force transfer by either the coracohumeral ligament (CHL) or the SS cord. The CHL is...
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Increased listening effort and cochlear neural degeneration underlie speech-in-noise deficits in normal-hearing middle-aged adults
प्रकाशित 2025-07-01पूर्ण पाठ प्राप्त करेंMiddle age represents a critical period of accelerated brain changes and provides a window for early detection and intervention in age-related neurological decline. Hearing loss is a key early marker of such decline and is linked to numerous comorbidities in older adults. Yet, ~10% of middle-aged in...
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The Safar Center for Resuscitation Research: Searching for Breakthroughs in the New Millennium
प्रकाशित 2006-12-01“…This review, written on the occasion of the 70th anniversary of the Institute for General Reanimatology of the Russian Academy of Medical Sciences, provides an update of recent research in the field of resuscitation medicine carried out at the Safar Center for Resuscitation Research at the University of Pittsburgh School of Medicine. Current and recent studies describing bench to bedside investigation in the areas of traumatic brain injury (TBI), cardiopulmonary arrest, hemorrhagic shock, and ultra-novel approaches to resuscitation are discussed. …”This review, written on the occasion of the 70th anniversary of the Institute for General Reanimatology of the Russian Academy of Medical Sciences, provides an update of recent research in the field of resuscitation medicine carried out at the Safar Center for Resuscitation Research at the Universit...
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New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain
प्रकाशित 2025-06-01पूर्ण पाठ प्राप्त करेंThe rodent olfactory system is unique in harboring two distinct postnatal neurogenic niches, the olfactory epithelium and the subventricular zone. This results in the ongoing generation of both olfactory sensory neurons (OSNs), which provide odor input to the brain, and multiple molecularly distinct...
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Faculty Reflections About Participating in International Medical School Curriculum Development, a Qualitative Study
प्रकाशित 2025-03-01“…Nazarbayev University School of Medicine selected the University of Pittsburgh School of Medicine to guide their curricular development. …”Nazarbayev University School of Medicine selected the University of Pittsburgh School of Medicine to guide their curricular development. University of Pittsburgh faculty members teaching in the medical school were asked to help develop the curriculum in Nazarbayev. Some were asked to travel to Nazar...
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Fatty acid nitroalkenes regulate intestinal lipid absorption
प्रकाशित 2025-08-01पूर्ण पाठ प्राप्त करेंFatty acid nitroalkenes (NO2-FA) are tissue-protective and anti-inflammatory endogenous lipid mediators. A unique electrophilic character promotes reversible reactions with protein thiols, influencing key cellular functions. Given their generation during digestion and therapeutic potential, understa...
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Patient Perceptions of a Population Health Management Program to Improve Kidney Care: Optimizing care in CKD
प्रकाशित 2025-07-01पूर्ण पाठ प्राप्त करेंRationale & Objective: A population health management intervention for a pragmatic cluster randomized control trial (Kidney CHAMP) aimed to improve care and outcomes in patients with chronic kidney disease (CKD) at high-risk of progression to dialysis dependence but not seeing a nephrologist...
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MAP2 phosphorylation: mechanisms, functional consequences, and emerging insights
प्रकाशित 2025-07-01पूर्ण पाठ प्राप्त करेंMicrotubule-associated protein 2 (MAP2) is a key regulator of cytoskeletal dynamics and neuronal function. It stabilizes microtubules, shapes dendrites, influences synaptic plasticity, and regulates transportation and protein synthesis through its interactions with other proteins. MAP2 undergoes ext...
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