Résultats de la recherche - "University of Pittsburgh"

Abstract Introduction Multiple effective antiretroviral‐based pre‐exposure prophylaxis (PrEP) modalities for HIV‐1 prevention are now available or under investigation but their safe rollout requires implementable HIV‐1 testing strategies that accurately identify rare cases of HIV‐1 acquisition. Curr...

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Abstract INTRODUCTION Research on diagnostic and biomarker disclosure has significantly increased, particularly in the field of Alzheimer's disease (AD). The psychological impact of learning amyloid positron emission tomography (PET) results has been frequently assessed using the Impact of Gene...

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A larger proportion of women in the United States than in any other developed country—though less than 1 per cent—relinquish infants for adoption [...]

Abstract: Non-Langerhans cell histiocytoses are a diverse group of histiocytic diseases. Different entities are defined based on clinical, histopathologic, and/or molecular characteristics. This study aimed to define NTRK-rearranged histiocytosis. Through international collaboration, we investigated...

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Structural competency (SC) is a framework that assists clinicians in naming and analyzing the structural drivers that fundamentally contribute to morbidity and mortality. Undergraduate and graduate medical education is grounded in the experiential learning model where trainees learn through supervis...

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Objective: to study the sensitivity of gastrointestinal stromal tumors (GISTs) to the topoisomerases type II inhibitors and ability of imatinib to enhance GISTs sensitivity to the chemotherapeutic drugs indicated above.Subjects and Methods. We studied the sensitivity of gastrointestinal stromal tumo...

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<b>Background/Objectives</b>: Thoracic outlet syndrome (TOS) is a rare and difficult-to-diagnose condition in children, characterized by the compression of neurovascular structures in the thoracic outlet. Neurogenic TOS (nTOS) often presents with nonspecific symptoms such as paresthesia,...

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Background The applications of 3D-printed implants in foot and ankle surgery are rapidly rising in popularity. These custom-made implants provide an alternative option for salvage in the setting of a variety of pathologies that are difficult and challenging to treat, including trauma, deformity and...

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Background: Left atrial appendage (LAA) occlusion (LAAO) is used to prevent thromboembolic events in high stroke risk patients. However, surgical LAA closure can fail, resulting in residual flow and thrombus formation. Case Summary: A 77-year-old man with a history of bioprosthetic valve replacement...

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Summary: Recent reports highlight the efficacy of engineered mycobacteriophages to treat non-tuberculosis mycobacterial disease. Molecular insights into mycobacteriophage architecture and host interactions could allow structure-guided phage engineering to increase efficacy and broaden host range, bu...

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IntroductionTauopathies, including Alzheimer’s disease (AD), feature abnormal accumulations of hyperphosphorylated Tau protein; however, their biomarker potential in traumatic brain injury (TBI) is not well-defined. This study investigated whether cerebrospinal fluid (CSF) phosphorylated Tau at thre...

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Aim. The main purpose of this work is to evaluate the Hemolung pumping ability and gas exchange effectiveness while using the catheters of smaller diameter and blood fl ow rates, applied in pediatrics.Material and methods. The bench testing of the device with pediatric catheters has been performed....

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The Fourth International Electronic Conference on Brain Sciences (IECBS 2024), after the strong success of the previous annual online conference, was held online from 23 to 25 October 2024. The scope of this online conference is to bring together well-known worldwide experts who are currently workin...

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Finn Arne Jørgensen is a professor of environmental history at the University of Stavanger in Norway. He studies the evolution of human relationships with nature over time and place. His latest book, titled Sharing Spaces: Technology, Mediation, and Human-Animal Relationships (2024, University of P...

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Abstract Objective Otitis media with effusion (OME) affects 90% of children before school age, with current guidelines recommending tympanostomy tubes for persistent OME and hearing loss after 3 months of “Watchful Waiting,” due to the risk of complications including long‐term conductive hearing los...

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ABSTRACT Urbanization is a major human‐mediated driver of environmental change. Plants in urban environments may differ in timing and investment in key life history traits compared to rural plants as a result of genetic differentiation or plastic responses to the urban environment. However, it is un...

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Metal ion measurements using inductively coupled plasma optical emission spectroscopy revealed twofold-higher zinc content in rat brain compared to spinal cord. One hypothesis to explain this difference is the high prevalence of synapses that corelease glutamate and zinc in the brain, marked by the...

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A sensitive and specific liquid chromatography-tandem mass spectrometry assay was developed for the quantification of chimeric aducanumab (chAdu), a therapeutic antibody targeting pathological amyloid plaques in Alzheimer’s disease, in murine biological matrices. This method addresses the challenges...

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