खोज परिणाम - "University of Pittsburgh"

The fibroblast (FB), cardiomyocyte (CM), and vascular endothelial cell (Vas_EC) are the three major cell types in the heart, yet their relationships during development are largely unexplored. To address this gap, we employed RNA staining of the FB marker gene Col1a1 together with the CM marker gene...

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Sedentary behavior has been associated with poor health outcomes, especially in older adulthood. Given that sedentary behavior is a highly prevalent, modifiable health behavior, there has been a recent increased interest in examining how sedentary behavior relates to cognition and brain health. The...

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<b>Background:</b> Cell-penetrating peptides cross cell membrane barriers while carrying cargoes in a functional form. Our work identified two novel lung-targeting peptides, S7A and R11A. Here, we present studies on biodistribution, the cell types targeted, and an in vitro proof of appli...

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In constructing quantum states at colliders, most efforts have focused on utilizing the particle decays to infer the spins to reconstruct the quantum density matrix. We show that the production kinematics of the particles provides sufficient information about the spins to establish quantum tomograph...

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Abstract Objective: To estimate the cost-effectiveness of methicillin-resistant Staphylococcus aureus (MRSA) nares poymerase chain reaction (PCR) use in pediatric pneumonia and tracheitis. Methods: We built a cost-effectiveness model based on MRSA prevalence and probability of empiric treatment...

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<b>Background/Objectives:</b> Ostomy creation surgery is a common intervention for patients with conditions such as colorectal cancer, ulcerative colitis, Crohn’s disease, or acute events like trauma and gastrointestinal perforation. Individuals with an ileostomy face unique challenges w...

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<italic>Goal:</italic> Create a semi-automated, graphical, stand-alone application that uses clinically available asynchronous pressure and Doppler velocity captures to rapidly calculate, display, and interpret the pulmonary vascular impedance (PVZ) spectra. <italic>Methods:</it...

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This review explores current and emerging neuromodulation techniques targeting the cardiac autonomic nervous system for the treatment and prevention of atrial and ventricular arrhythmias. Arrhythmias remain a significant cause of morbidity and mortality, with the autonomic nervous system playing a c...

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Purpose: To describe rates of revision surgery and recurrence events, as well as to evaluate functional outcomes and return to play (RTP) of a cohort of Division 1 (D1) collegiate American football players who underwent arthroscopic labral repair for shoulder instability. Methods: D1 collegiate Amer...

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ABSTRACT Objective This study aimed to explore changes in sway during single tasks and dual tasks in adolescents with and without sport concussion (SC). Methods A cross‐sectional study of 57 adolescents with an SC and 67 healthy participants was compared on static balance during single‐ and dual‐tas...

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Abstract A highly conductive and transparent oxide/metal/oxide (OMO) multilayer transparent electrode is developed by flash lamp annealing (FLA). A transient thermal effect of FLA on the sandwich structure of the ultrathin Ag layer and zinc‐doped indium oxide (IZO) layer is systematically investigat...

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Abstract Introduction In 2021, the Learning Health Systems Rehabilitation Research Network (LeaRRn) developed and administered a needs assessment survey, based on the Agency on Healthcare Research and Quality's (AHRQ's) original seven domains of learning health systems (LHS) researcher cor...

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Background: The months following hospitalization for sepsis and lower respiratory tract infection can often be very difficult for patients. Many will have subsequent clinical deterioration, which for some requires hospital readmission while, for others, transition to hospice care may be more appropr...

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Staphylococcus aureus is the leading cause of skin infections in the U.S., and its rapid evolution and resistance to antibiotics create a barrier to effective treatment. In this study, we engineered a composite membrane with bacterial cellulose and carbon nanotubes (BC-CNT) as an electroactive dress...

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Introduction Since the COVID-19 pandemic, internal medicine (IM) residents have provided patient care via telemedicine in their continuity clinics but often without formal training in telemedicine skills. To address this education gap, we developed a two-part curriculum to improve IM residents’ self...

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ABSTRACT RNA alternative splicing is a fundamental cellular process implicated in cancer development. Kaposi’s sarcoma-associated herpesvirus (KSHV), the etiological agent of multiple human malignancies, including Kaposi’s sarcoma (KS), remains a significant concern, particularly in AIDS patients. A...

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