Ngā hua rapu - "University of Pittsburgh"
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Intervertebral Lumbar Spine Kinematics in Chronic Low Back Pain Patients Measured Using Biplane Radiography
I whakaputaina 2025-06-01Whiwhi kuputuhi katoaABSTRACT Background Chronic low back pain (cLBP) presents as a heterogeneous condition, making diagnosis and treatment challenging. Lumbar spine intervertebral kinematics may provide an objective assessment of patients with cLBP that may be used to inform treatment decisions and evaluate the efficac...
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No difference in failure between static, articulating, and prosthetic low-friction spacers for periprosthetic joint infection of total knee arthroplasty
I whakaputaina 2025-07-01Whiwhi kuputuhi katoa<p><strong>Introduction</strong>: Two-stage revision with an antibiotic spacer is the gold-standard treatment of prosthetic joint infection (PJI) for total knee arthroplasty (TKA). Multiple spacer designs exist, including static, articulated, and prosthetic low-friction (PALF) spac...
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Type of acute periprosthetic joint infection may not affect failure of debridement, antibiotics, and implant retention after total knee arthroplasty
I whakaputaina 2025-07-01Whiwhi kuputuhi katoa<p><strong>Introduction:</strong> In periprosthetic joint infection (PJI) following total knee arthroplasty (TKA), debridement, antibiotics, and implant retention (DAIR) is a common procedure with a high rate of failure. Timing of infection can be used to stratify acute PJI into ac...
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Editorial: Long-term effects of adolescent stress, sleep deprivation, or circadian disruption on mood and anxiety
I whakaputaina 2025-07-01 Whiwhi kuputuhi katoa
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BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4
I whakaputaina 2025-07-01Whiwhi kuputuhi katoaSummary: In B cells, BLIMP1 is required for plasma cell differentiation. BLIMP1 is also expressed in some germinal center (GC) B cells (GCBC), yet the role of BLIMP1 in GCBC is not understood. Here we generated mixed bone marrow (BM) chimeric mice using Prdm1+/+ CD19Cre and Prdm1fl/fl CD19Cre BM, al...
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Occult Node Detection With Lobectomy Versus Segmentectomy for Stage IA NSCLC
I whakaputaina 2025-08-01Whiwhi kuputuhi katoaObjective: Besides the discussion on parenchymal margin, data on the extent of lymph node (LN) dissection are scarce, especially in segmentectomy. This study aimed to investigate the extent of LN dissection and detection of occult disease in segmentectomy compared with lobar resection. Methods: We p...
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NetBat: A network-driven harmonization method for structural connectivity
I whakaputaina 2025-08-01Whiwhi kuputuhi katoaAs the practice of aggregating multi-site neuroimaging data has become more common, the field of neuroscience has increasingly recognized the importance of harmonization , or the removal of scanner effects from brain imaging data. While many harmonization methods exist, like ComBat and CovBat, few e...
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Prior year hospital admission predicts 30-day hospital readmission after spine surgery
I whakaputaina 2025-09-01Whiwhi kuputuhi katoaABSTRACT: Background: Reducing hospital readmissions postspine surgery is crucial for improving care quality. Currently, no specific scoring system exists to stratify patients by readmission risk in spine surgery. The objective of this study was to evaluate risk factors for 30-day hospital readmiss...
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Strategies to Promote Resiliency: A Randomized Embedded Multifactorial Adaptative Platform (REMAP) Clinical Trial to Study Interventions to Improve Recovery After Surgery in High-R...
I whakaputaina 2025-06-01Whiwhi kuputuhi katoaObjective:. In a randomized, embedded, multifactorial, adaptive platform (REMAP) trial, we hypothesized that perioperative metformin would improve postoperative time alive and out of the hospital, defined by 90-day hospital-free days (HFD-90), among nondiabetic aged adults. Background:. As our popul...
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Chronic benzodiazepine treatment triggers gephyrin scaffold destabilization and GABAAR subsynaptic reorganization
I whakaputaina 2025-07-01Whiwhi kuputuhi katoaBenzodiazepines (BZDs) are important clinical drugs with anxiolytic, anticonvulsant, and sedative effects mediated by potentiation of inhibitory GABA type A receptors (GABAARs). Tolerance limits the clinical utility of BZDs, yet the mechanisms underlying tolerance after chronic exposure have not bee...
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Comparison of Pyrazinamide with Isoniazid for Their Effects on the Heme Biosynthetic Pathway in Mouse Liver
I whakaputaina 2025-05-01Whiwhi kuputuhi katoa<b>Background/Objectives:</b> Isoniazid (INH) and pyrazinamide (PZA) are first-line drugs used to treat tuberculosis (TB), but their use is generally contraindicated in patients with porphyria, a group of metabolic disorders caused by defects in the heme biosynthetic pathway. To investig...
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Multivariate analysis--VI proceedings of the Sixth International Symposium on Multivariate Analysis
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Patient and Provider Perspectives on Cesarean Delivery Pain and Anesthesia Experiences: A Qualitative Study
I whakaputaina 2025-01-01Whiwhi kuputuhi katoaBackground: There is a lack of evidence on the importance of pain or other aspects of clinical care in the overall patient experience and patient-centered outcomes in cesarean delivery. The purpose of this study was to discover patient priorities in cesarean delivery anesthesia experience, to compar...
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Psychophysical correlates of labor pain intensity and unpleasantness
I whakaputaina 2025-12-01Whiwhi kuputuhi katoaThe neurobiological mechanisms linking perinatal pain and mood disorders remain unclear. Emotional dimensions of labor pain, particularly unpleasantness, may reflect engagement of limbic pathways shared with affective disorders. This study examined whether prenatal quantitative sensory testing (QST)...
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The effect of bony morphology on anterior cruciate ligament injury and surgery
I whakaputaina 2024-03-01Whiwhi kuputuhi katoaThe exploration of underlying biological risk factors for anterior cruciate ligament (ACL) injury has generated a substantial body of literature describing the role of bony morphology of the knee. Morphological risk factors, such as poor tibiofemoral joint congruity, a narrow femoral intercondylar n...
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Identifying a Biological Signature of Trauma-Related Neurodegeneration Following Repeated Traumatic Brain Injuries Compared with Healthy Controls
I whakaputaina 2025-01-01Whiwhi kuputuhi katoaThe objective of this study was to compare participants at-risk for trauma-related neurodegeneration to a healthy control group on outcomes associated with Alzheimer’s disease (AD), such as subjective symptoms, neurocognitive performance, plasma biomarkers, volumetrics, amyloid-beta (Aβ) positron em...
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A Review of Perilunate Dislocations and Concomitant Acute Carpal Tunnel Syndrome: When Should the Carpal Tunnel be Released?
I whakaputaina 2025-09-01Whiwhi kuputuhi katoaPerilunate dislocations (PLDs) are severe injuries of the wrist often resulting from a high-energy trauma. Given the traumatic mechanism and complexity of the injury itself, PLDs often require urgent intervention in the form of early open reduction and surgical stabilization. One potential, but seve...
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