Torthaí cuardaigh - "Treatment-resistant depression"

Background: Treatment resistant depression (TRD) has been identified as non-response to depression with adequate dose and trial of two antidepressant medications of different classes. Near about 30% depressive patients are TRD cases. Olanzapine‐fluoxetine combination, rTMS, Intravenous ketamine and...

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Hiroko Sugawara,1,2 Kaoru Sakamoto,1 Tsuyoto Harada,3 Satoru Shimizu,4 Jun Ishigooka1 1Department of Psychiatry, Tokyo Women’s Medical University, 2Support Center for Women Health Care Professionals and Researchers, Tokyo Women’s Medical University, Shinjuku-ku, 3Departm...

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Objective: In this study, we intended to understand how psychiatrists in Taiwan value different attributes of pharmacological treatments for major depressive disorder with suicidal ideation or intent (MDSI). Novel therapies for MDSI differ from standard treatments in their route of administration, e...

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<b>Background:</b> Insomnia, as one of the most common sleep disorders, is a significant health problem, especially among patients suffering from drug-resistant depression. Problems related to the quality of sleep in that population can significantly affect the effectiveness of treatment...

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Abstract Background Heterogeneous symptoms in major depression contribute to unsuccessful antidepressant treatment, termed treatment-resistant depression (TRD). Psychometric network modeling conceptualizes depression as interplay of symptoms with potential benefits for treatment; however, a knowledg...

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ObjectiveTo examine longitudinal associations of psychological distress, community integration, suicide ideation, and attempts within 3-month post-discharge period among patients with treatment-resistant depression (TRD).MethodsProspective study design with a 3-month followed-up from the hospital ad...

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Masatake Kurita,1&amp;ndash;3 Takahiro Moriya,2 Satoshi Nishino,2,4 Eishin Hirata,4 Noriyasu Hirasawa,5 Yoshiro Okubo,3 Tadahiro Sato4 1Wakamiya Hospital, Koutokukai, Yoshihara, Yamagata, 2Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, M...

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Psychiatric neurosurgery is undergoing a profound transformation, propelled by advances in neurotechnology, connectomics, and personalized medicine. Once controversial, surgical interventions are now guided by detailed functional brain mapping and precise neuromodulation techniques, such as deep bra...

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<b>Objectives</b>: (R)-ketamine hydrochloride injection is a novel, rapid-acting antidepressant for the treatment of treatment-resistant depression. The aim of this study was to assess the pharmacokinetics, safety, and tolerability of (R)-ketamine hydrochloride injection in healthy Chine...

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Aim: Estimate the cost-per-remitter with esketamine nasal spray plus an oral antidepressant (ESK NS + OAD) versus quetiapine extended release plus an oral antidepressant (QTP XR + OAD) among adults with treatment-resistant depression (TRD). Materials & methods: An Excel-based model was develop...

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Management of treatment-resistant depression is one of the most important problems in modern psychiatry. Comorbidity of depression with medical diseases is one of the predisposing factors for the development of treatment resistance due to various mechanisms, including genetic, endocrine, neuroimmune...

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Given the differences in the pharmacological and clinical effects of antidepressants, criteria for their differential choice in the treatment of depression associated with comorbid medical illnesses are suggested. Based on these criteria and general rules of clinical pharmacology, principles of anti...

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Treatment Resistant Depression is characterized by inadequate response to at least two adequate trials of antidepressants, highlighting the need for alternative or adjunctive strategies. Emerging evidence suggests omega-3 polyunsaturated fatty acids, particularly eicosapentaenoic acid, may offer the...

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Aim: We investigated the impact of repetitive transcranial magnetic stimulation (rTMS) for treatmentresistant depression on healthcare resource utilization as well as commercial and Medicare Fee-for-Service payer costs. Materials & methods:We conducted a retrospective observational analysis of...

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