Ngā hua rapu - "Taste receptor"
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The roles of bitter and sweet taste receptors in food allergy: Where are we now?
I whakaputaina 2025-07-01Ngā marau: Whiwhi kuputuhi katoaFood allergy (FA) is a growing global concern, which contributes significantly to anaphylaxis and severe allergic reactions. Despite advancements in treatments like allergen immunotherapy and biologics, current approaches have notable limitations and there is a pressing need for new therapeutic stra...
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The three-dimensional structure prediction of human bitter taste receptor using the method of AlphaFold3
I whakaputaina 2025-01-01Ngā marau: “…Human bitter taste receptor…”Bitter taste receptors (T2Rs), a subfamily of G protein-coupled receptors, are expressed not only in oral tissues but also in extraoral sites, playing key roles in physiological processes such as the gut-brain axis. However, structural information on T2Rs is limited, with only two human T2Rs, T2R14...
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Gustometry in various variants of bronchial asthma: Sensitivity thresholds for bitter and sweet tast
I whakaputaina 2021-03-01Ngā marau: Whiwhi kuputuhi katoaThe first studies were published on the possible pathogenetic role of so-called ectopically localized taste receptors in bronchial asthma. The receptors for bitter and sweet taste, may, apparently, have opposite functions, but in available literature there is no data on the balance of sensitivity fo...
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Artificial Sweeteners and Glycemic Control: Implications for Metabolic Health
I whakaputaina 2025-06-01Ngā marau: Whiwhi kuputuhi katoaArtificial sweeteners (AS), commonly used as sugar substitutes, have gained popularity due to their low caloric value and perceived benefits in supporting glycemic control. Initially introduced to help reduce sugar consumption, their actual impact on glucose metabolism in humans remains unclear. Th...
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Bitter Taste Receptors in Bacterial Infections and Innate Immunity
I whakaputaina 2025-07-01Ngā marau: Whiwhi kuputuhi katoaABSTRACT Background Bitter taste receptors (TAS2Rs), originally identified for their role in gustation, are now recognized for their functions in extraoral tissues, particularly in innate immune responses. TAS2Rs detect bacterial quorum sensing molecules (QSMs) and other metabolites, enabling the ho...
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BuZhong YiQi Formula Alleviates Taste Disorders in Rats with Type 2 Diabetes Mellitus by Increasing the Number of Taste Buds and the Expression of Signaling Molecules in Taste Tran...
I whakaputaina 2025-06-01Ngā marau: Whiwhi kuputuhi katoa<b>Background:</b> Taste disorders in patients with type 2 diabetes mellitus (T2DM) have a negative impact on their quality of life and glycemic control, and treatment options are limited. Buzhong yiqi formula (BZYQF) improves T2DM symptoms but its effects on T2DM-induced taste disorders...
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Bitter taste receptor agonists induce vasorelaxation in porcine coronary arteries
I whakaputaina 2025-07-01Ngā marau: Whiwhi kuputuhi katoaBackgroundIschemic heart disease (IHD) remains a leading cause of global morbidity and mortality, necessitating the search for novel therapeutic approaches. Recent studies have identified bitter taste receptors (TAS2Rs) in vascular smooth muscle cells as potential therapeutic targets because of thei...
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