Search Results - "Stanford University"
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PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson’s disease
Published 2025-08-01Get full textSummary: Leucine-rich repeat kinase 2 (LRRK2) phosphorylates a subset of Rab GTPases that regulate receptor trafficking, and LRRK2-activating mutations are linked to Parkinson’s disease. Rab phosphorylation is a transient event that can be reversed by phosphatases, including protein phosphatase, Mg2...
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Antispike IgG antibody decay after immunisation with fractional versus full booster doses of COVID-19 vaccines: a 6-month longitudinal analysis of the FRACT-COV trial in Brazil
Published 2025-07-01Get full textObjectives To compare antispike IgG levels over a period of 182 days of follow-up in healthy adults who received full or fractional booster doses of BNT162b2 or AZD1222 after completing a primary series of Sinovac, BNT162b2 or AZD1222.Design Double-blind, parallel-arm, phase IV randomised trial.Sett...
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Altered immunometabolic response to fasting in humans living with obesity
Published 2025-07-01Get full textSummary: Fasting and ketosis are gaining interest for treating obesity-related immunometabolic dysfunction. We aimed to (1) characterize systemic and T cell immunometabolic responses to a 48-h fast in humans and (2) determine if responses differed between individuals with (O-BMI) and without (L-BMI)...
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Pharyngeal Stenosis and Swallowing Dysfunction Following Laryngectomy: A Scoping Review
Published 2025-05-01Get full textBackground: Pharyngeal stenosis (PS) is a common sequela of a total laryngectomy (TL), and the most common cause of postoperative dysphagia. Its exact incidence is not known. A greater understanding of this clinical complication could serve to better inform patients considering a laryngectomy. Objec...
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The four Cs of physician leadership: A key to academic physician success
Published 2024-09-01Get full textLeadership is increasingly recognized as important in medicine. Physician leadership impacts healthcare delivery and quality. Little work has been done to determine how physician leadership in practice aligns with established models in leadership theory. We conducted 40 semi-structured, 50-minute i...
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Imprint Desorption Electrospray Ionization Mass Spectrometry Imaging (IDESI-MSI) Reveals Absorption of Triclopyr-Based Herbicide in Plants and Mouse Organs
Published 2025-06-01Get full textBackground: Understanding the absorption and distribution of herbicides in plants and animal tissues is essential for assessing their potential risks to human health. Method: In this study, we employed imprint desorption electrospray ionization mass spectrometry imaging (IDESI-MSI) to visualize in b...
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Rising drug overdose deaths in chronic liver disease in the United States, 2015–2023
Published 2025-07-01 Get full text
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Colonic dilation is associated with increased central line associated blood stream infection for patients with intestinal failure
Published 2025-01-01Get full textIntroduction: Management of intestinal failure involves supplemental nutrition and complication minimization to achieve enteral autonomy. Previous research to identify prognostic factors in IF focused on the small bowel, yet little work has been done to associate the colon with IF outcomes. We hypot...
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Abundant and metabolically flexible bacterial lineages underlie a vast potential for rubisco-mediated carbon fixation in the dark ocean
Published 2025-06-01Get full textAbstract Background Rubisco is among the most abundant enzymes on Earth and is a critical conduit for inorganic carbon into the biosphere. Despite this, the full extent of rubisco diversity and the biology of organisms that employ it for carbon fixation are still emerging, particularly in unlit ecos...
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Nonlinear compressive reduced basis approximation for PDE’s
Published 2023-09-01Get full textLinear model reduction techniques design offline low-dimensional subspaces that are tailored to the approximation of solutions to a parameterized partial differential equation, for the purpose of fast online numerical simulations. These methods, such as the Proper Orthogonal Decomposition (POD) or R...
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The State of High‐Resolution Imaging of the Human Inner Ear: A Look Into the Black Box
Published 2025-07-01Get full textAbstract Unlike most medical fields, otology has not benefited from the transformative impact of high‐resolution, cellular‐level imaging. The sensorineural cells required for human hearing—located within the cochlea—are just 10–50 µm, placing them outside the resolution of magnetic resonance imaging...
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Impact of the 2015 American Thyroid Association Guidelines on Treatment of Low‐Risk Thyroid Cancer
Published 2025-06-01Get full textABSTRACT Objectives The 2015 American Thyroid Association (ATA) guidelines recommended lobectomy for management of low‐risk differentiated thyroid carcinomas (DTC), aiming to mitigate overtreatment. The primary objective of this study was to assess the impact of the 2015 ATA guidelines on the rates...
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