Rezultaty - "Santa Clara, California"

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  1. 1
    Evaluation of a high-throughput Candidozyma auris assay for use on the cobas 5800/6800/8800 omni Utility Channel

    Evaluation of a high-throughput Candidozyma auris assay for use on the cobas 5800/6800/8800 omni Utility Channel od Jeffrey Alexander, Natacha Martins-Sorenson, Arrash Moghaddasi, Andrew T. Hill, Jody Harris, Stephen McCune, Erin Gick, YanChun Zhu, Sudha Chaturvedi, Michael Lewinski, Kyle C. Cady

    Wydane 2025-07-01

    ABSTRACT Candidozyma auris (formerly known as Candida auris) is an emerging worldwide fungal pathogen associated with difficult-to-treat nosocomial infections. Screening of patients for colonization is a recommended strategy to track and prevent hospital spread and outbreaks caused by C. auris. To f...

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  2. 2
    DFT analysis of the [3 + 2] heterocyclization reaction of ((1,2,4-triazole(1,3,4-oxadiazole)-3(2)-yl)methyl)thiopyrimidines

    DFT analysis of the [3 + 2] heterocyclization reaction of ((1,2,4-triazole(1,3,4-oxadiazole)-3(2)-yl)methyl)thiopyrimidines od Yu. V. Karpenko

    Wydane 2025-03-01

    The article examines the mechanisms of the heterocyclization reaction using density functional theory (DFT) methods. A quantum-chemical analysis of the starting compounds, transition states, and products was conducted, with energy barriers and key reaction stages identified. Particular attention was...

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    “…Materials and methods. 1H and 13C NMR spectra were recorded on a Bruker AC-500 spectrometer (500 MHz and 125 MHz, respectively) in DMSO-d6, using TMS as the internal standard (Agilent Technologies, Santa Clara, California, USA). LC-MS analysis was performed using an Agilent 1260 Infinity HPLC System equipped with a diode-array detector and proton ionization. …”
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  3. 3
    The Association of Aortic Stenosis Severity and Symptom Status With Morbidity and Mortality

    The Association of Aortic Stenosis Severity and Symptom Status With Morbidity and Mortality od Matthew D. Solomon, MD, PhD, Alan S. Go, MD, Thomas Leong, MPH, Elisha Garcia, BS, Kathy Le, MPH, Femi Philip, MD, Edward McNulty, MD, Jacob Mishell, MD, Andrew N. Rassi, MD, David C. Lange, MD, Catherine Lee, PhD, Anthony DeMaria, MD, Rick Nishimura, MD, Andrew P. Ambrosy, MD

    Wydane 2025-08-01

    Background: The relationship between aortic stenosis (AS) severity, AS-related symptoms, and clinical outcomes is poorly understood. Objectives: The purpose of this study was to evaluate whether potential AS-related symptoms at diagnosis are associated with outcomes, including death and AS-related h...

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  4. 4
    Dietary supplementation with L-carnitine elevates intracellular carnitine levels and affects gene expression of SLC25A20 and COX4I1, as well as non-mitochondrial respiration of bovine blood cells during systemic immune challenge

    Dietary supplementation with L-carnitine elevates intracellular carnitine levels and affects gene expression of SLC25A20 and COX4I1, as well as non-mitochondrial respiration of bov... od Leonie Seemann, Susanne Kersten, Susanne Bühler, Fabian Billenkamp, Ulrich Meyer, Christian Visscher, Korinna Huber, Erika Most, Klaus Eder, Sven Dänicke, Jana Frahm

    Wydane 2025-07-01

    L-carnitine plays a key role in shuttling free fatty acids from the cytosol into the mitochondrial matrix. Fatty acids, among other substrates, are utilized by immune cells as an energy source. Therefore, L-carnitine, which is authorized as a feed additive in cattle, may influence the metabolism of...

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    “…The used methods included high-performance liquid chromatography coupled with mass spectrometry, Alamar Blue assay, real-time qPCR, and the Mito Stress Test of the Seahorse Analyzer (Agilent, Santa Clara, California, USA). L-carnitine supplementation significantly increased intracellular concentrations of carnitine and its precursor γ-butyrobetaine in PBMC of dairy cows. …”
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