Search Results - "STAT1"

Suggested Topics within your search.
  • Showing 1 - 10 results of 10
Refine Results
  1. 1
    Stat 1 : a statistical toolbox /

    Stat 1 : a statistical toolbox / by Brennan, Jerry M.

    Published 1986 Subjects: “…Stat 1 (Computer program).…”
    Book

    Save to List
    Saved in:
  2. 2
    Characterization of a STAT-1 Knockout Mouse Model for Machupo Virus Infection and Pathogenesis

    Characterization of a STAT-1 Knockout Mouse Model for Machupo Virus Infection and Pathogenesis by Stephanie R. Monticelli, Ana I. Kuehne, Russell R. Bakken, Susan R. Coyne, Kenise D. Lewis, Jo Lynne W. Raymond, Xiankun Zeng, Joshua B. Richardson, Zebulon Lapoint, Jennifer L. Williams, Christopher P. Stefan, Jeffrey R. Kugelman, Jeffrey W. Koehler, Andrew S. Herbert

    Published 2025-07-01

    Machupo virus (MACV), a member of the <i>Arenaviridae</i> family and causative agent of Bolivian hemorrhagic fever, results in lethality rates of 25–35% in humans. Mice lacking the signal transducer and activator of transcription 1 (STAT-1<sup>−/−</sup>) have previously been...

    Full description

    Subjects: Get full text
    Article

    Save to List
    Saved in:
  3. 3
    In Silico Prioritization of STAT1 3′ UTR SNPs Identifies rs190542524 as a miRNA-Linked Variant with Potential Oncogenic Impact

    In Silico Prioritization of STAT1 3′ UTR SNPs Identifies rs190542524 as a miRNA-Linked Variant with Potential Oncogenic Impact by Ebtihal Kamal

    Published 2025-04-01

    Background: Single-nucleotide polymorphisms (SNPs) are associated with multiple disorders and various cancer types. In the context of cancer, alterations within non-coding regions, specifically 3′ untranslated regions (3′ UTR), have proven substantially important. Methods: In this study, we utilized...

    Full description

    Subjects: Get full text
    Article

    Save to List
    Saved in:
  4. 4
    Phospholipase PLA2G16 Accelerates the Host Interferon Signaling Pathway Response to FMDV

    Phospholipase PLA2G16 Accelerates the Host Interferon Signaling Pathway Response to FMDV by Bingjie Sun, Xiaodong Qin, Taoqing Zhang, Sujie Dong, Yinbo Ye, Changying Wang, Yan Zhang, Rongzeng Hao, Yi Ru, Hong Tian, Haixue Zheng

    Published 2025-06-01

    PLA2G16 is a member of the phospholipase A2 family that catalyzes the generation of lysophosphatidic acids (LPAs) and free fatty acids (FFAs) from phosphatidic acid. Previously, PLA2G16 was found to be a host factor for picornaviruses. Here, we discovered that the Foot-and-Mouth Disease Virus (FMDV)...

    Full description

    Subjects: Get full text
    Article

    Save to List
    Saved in:
  5. 5
    Case Report: A novel KRT74 variant in an eight-year-old boy with alopecia totalis successfully treated with baricitinib

    Case Report: A novel KRT74 variant in an eight-year-old boy with alopecia totalis successfully treated with baricitinib by Yidong Tan, Yidong Tan, Jinxiang Yang, Jinxiang Yang, Xuanyi Chen, Xuanyi Chen, Yihang Shen, Yihang Shen, Zhe Wu, Zhe Wu, Weinan Zhou, Weinan Zhou, Zhirong Yao, Zhirong Yao, Jingjun Zhao, Jingjun Zhao, Jianying Liang, Jianying Liang

    Published 2025-07-01

    Alopecia areata is an autoimmune condition characterized by non-scarring hair loss, with genetic factors playing a significant role in disease susceptibility. We report the case of an 8-year-old boy with alopecia totalis harboring a heterozygous KRT74 variant. While his mother and brother share this...

    Full description

    Subjects: Get full text
    Article

    Save to List
    Saved in:
  6. 6
    Cimifugin ameliorates ulcerative colitis-related lung injury by modulating the JAK1/STAT1 signaling pathway and macrophage M1 polarization

    Cimifugin ameliorates ulcerative colitis-related lung injury by modulating the JAK1/STAT1 signaling pathway and macrophage M1 polarization by Guanyuan Wang, Fan Yang, Fan Yang, Guodong Zang, Guodong Zang, Ning Shen, Ning Shen, Lina Huang, Lina Huang, Zhaotian Ma, Ming Li

    Published 2025-07-01

    IntroductionUlcerative colitis (UC)-related lung injurys is a commonly overlooked extraintestinal manifestation and there are currently no drugs with definitive efficacy available. Cimifugin has been found to inhibit aberrant inflammation and oxidative stress, but its efficacy in UC-related lung inj...

    Full description

    Subjects: Get full text
    Article

    Save to List
    Saved in:
  7. 7
    IFN&amp;alpha;/JAK/STAT1 Axis-Induced FBXO4 Modulates Muscle Cell Differentiation via &amp;beta;-Catenin Degradation in Dermatomyositis

    IFN&amp;alpha;/JAK/STAT1 Axis-Induced FBXO4 Modulates Muscle Cell Differentiation via &amp;beta;-Catenin Degradation in Dermatomyositis by Yin L, Yang H, Fu M, Bai Y, Hu N, Sun H

    Published 2025-06-01

    Liguo Yin,1,2 Hanbo Yang,3 Min Fu,1,2 Yanyan Bai,1,2 Naiwen Hu,1,2 Hongsheng Sun1,2 1Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China; 2Department of Rheumatology and Immunology, Shandong Provin...

    Full description

    Subjects: Get full text
    Article

    Save to List
    Saved in:
  8. 8
    Wenqing Yin Attenuates the Allergic Contact Dermatitis Response by Inhibiting the JAK2/STAT1 and MAPK Signaling Pathways

    Wenqing Yin Attenuates the Allergic Contact Dermatitis Response by Inhibiting the JAK2/STAT1 and MAPK Signaling Pathways by Ren M, Li S, Li S, Tan Z, Shi J

    Published 2025-05-01

    Mengyue Ren,1,&amp;ast; Siman Li,1,&amp;ast; Shaoqiang Li,2 Zhiwei Tan,1 Jun Shi1 1School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510000, People’s Republic of China; 2Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Research Inst...

    Full description

    Subjects: Get full text
    Article

    Save to List
    Saved in:
  9. 9
    Uncovering hidden immune defects in childhood granulomatous disorders: a case report

    Uncovering hidden immune defects in childhood granulomatous disorders: a case report by Walter Maria Sarli, Walter Maria Sarli, Francesca Quaranta, Clementina Canessa, Lorenzo Lodi, Laura Pisano, Anna Maria Buccoliero, Teresa Oranges, Elena Sieni, Gabriele Simonini, Gabriele Simonini, Luca Bartolini, Luca Bartolini, Elisabetta Venturini, Luisa Galli, Luisa Galli, Chiara Azzari, Chiara Azzari, Silvia Ricci, Silvia Ricci

    Published 2025-07-01

    Granulomatous diseases in childhood present a complex diagnostic landscape, particularly when histological and clinical findings overlap with those of systemic inflammatory or histiocytic disorders. A subset of these conditions may represent the clinical onset of inborn errors of immunity (IEI), suc...

    Full description

    Subjects: Get full text
    Article

    Save to List
    Saved in:
  10. 10
    LINC2781 enhances antiviral immunity against coxsackievirus B5 infection by activating the JAK-STAT pathway and blocking G3BP2-mediated STAT1 degradation

    LINC2781 enhances antiviral immunity against coxsackievirus B5 infection by activating the JAK-STAT pathway and blocking G3BP2-mediated STAT1 degradation by Jiayu Zhang, Jing Li, Yonghan Luo, Timothy J. Mahony, Jingru Gao, Yanchun Wang, Xiaotao Yang, Fan Yang, Xia Ou, Jihong Zhang, Heng Yang, Wei Chen

    Published 2025-07-01

    ABSTRACT Coxsackievirus B5 (CVB5) is a primary causative agent of hand, foot, and mouth disease (HFMD), and some cases are also associated with severe complications through invasion of the central nervous system, resulting in death. Currently, there are no specific antiviral drugs or effective vacci...

    Full description

    Subjects: Get full text
    Article

    Save to List
    Saved in:

Search Tools: