Search Results - "Neurotransmitters"

The FDA approved rufinamide, chemically 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide, a triazole-based scaffold, as an anticonvulsant drug in 2008. It is mainly used to treat seizures associated with Lennox–Gastaut Syndrome (LGS). The exact mechanism of rufinamide is unknown, but some lite...

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The relationship between various central nervous system (CNS) disorders linked to pesticide exposure highlights a growing concern worldwide, as the extensive use of these compounds causes toxic effects on the CNS of non-target organisms. Reports indicate that exposure to pesticides, including carbam...

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Sarcopenia is the age-related degeneration of skeletal muscle. Healthy skeletal muscle secretes metabolites and macromolecules that are systemically important for the immune system (e.g. myokines) and the central nervous system (e.g. BDNF). Exercise interventions to stimulate skeletal muscle are the...

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Metallo-phthalocyanines (MPcs) are versatile materials with applications in electroanalysis because of their superior catalytic properties. This review presents the electrochemical methods based on MPc-modified electrodes and reports some of their remarkable properties and applications in the electr...

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Immune cells and molecules, as well as synaptic transmission molecules play a regulatory role in the communication pathways of the entire body when it is necessary to engage all body resources in the fight against infections or tumor cells wherever they appear. In potential allergy, the neuroimmune...

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The article discusses the role of inflammatory reactions in the formation of attention deficit hyperactivity disorder (ADHD). Based on a wide and modern material, the mechanisms of development of oxidative stress with the formation of free radicals are considered, which, in turn, initiate a cascade...

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Background: Alterations in the levels of beta-endorphins and serotonin are heavily involved in the mood dysregulation regularly observed in individuals with methamphetamine use disorder, with lower levels of these neurotransmitters contributing to mood disturbances commonly seen in addiction. Such...

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BackgroundNeurotransmitters are key signaling molecules in the brain-gut axis, may be involved in stress-induced ulcer damage.ObjectiveThis study aims to address the relationship between gut microbiota and the stress response is examined in this review, with a focus on how neurotransmitters moderate...

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Background. Determining changes in the content of monoamine neurotransmitters and their metabolites in brain structures is a necessary part of studying the pharmacodynamics of  antiparkinsonian drugs. A  method for  the  joint determination of norepinephrine, adrenaline, dopamine, serotonin, 5-hydro...

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Electroanalysis of monoamine neurotransmitters is a useful tool for monitoring relevant neurodegenerative disorders and diseases. Electroanalysis of neurotransmitters using analytical devices consisting of electrodes modified with tailored and nanostructured composite materials is an active research...

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Purpose of the research: Iron deficiency (ID) is one of the most common nutritional deficiencies globally and may play a role in the development of depressive symptoms, even in the absence of anemia. This review explores the physiological links between iron status and brain function, examines cu...

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The Siberian wood frog Rana amurensis Boulenger, 1886 is the most hypoxia-tolerant amphibian. It can survive for several months in an almost complete absence of oxygen. Little is known about the mechanisms of this remarkable resilience, in part because studies of amphibian genomes are impeded by the...

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<b>Background/Objectives</b>: Yawning, a common physiological behavior, has emerged as a potential biomarker for drug responsiveness and side effects. This scoping review synthesizes current evidence on drug-induced yawning (DIY), focusing on its neurobiological mechanisms and clinical i...

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The brain is extremely complicated three dimensional structures made up of interconnected neurons and neuroglia cells. It entails all type of functions of our body whether we are healthy or in disease conditions. Brain is accountable for our connectivity with the surroundings; all this is performed...

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Background: Age-related cognitive decline is a common biological phenomenon that appears to be driven by accelerated oxidative stress pathways. As natural polyherbal phytoconstituents positively modulate such pathological changes, herbal formulations are gaining notable attention in the mitigation o...

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<b>Background:</b> <i>Areca catechu</i> L. is an evergreen tree belonging to the Arecaceae family. As an important traditional Chinese medicine, it has wide applications in the field of herbal medicine. Arecoline is the main active component responsible for its medicinal effe...

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The domestication of animals was crucial for the civilization evolutionary experiment. The main characteristic of domesticated animal is tame behavior towards man. D.K. Belyaev suggested that the domestication was carried out by man of the Stone Age as unintended selection of nonaggressive animals....

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The human gastrointestinal tract harbors a complex and diverse microbial community. Emerging evidence has revealed bidirectional communication between the gut microbiome and the central nervous system, termed the “microbiota–gut–brain axis”. This axis serves as a critical regulator of glial cell fun...

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Aim: to assess the level of stress hormones (cortisol in saliva), neurotransmitters (serotonin in blood serum, dopamine in blood plasma) in relation to eating habits, anxiety and depression levels in patients with IBS.Materials and methods. An open cohort prospective study was conducted with the inc...

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