Search Results - "Natural sciences"

Summary: We propose a time-domain adjoint optimization method for achromatic metalens design, achieving high efficiency and near-uniform spectral response. Unlike frequency-domain approaches, which require simulations for each sampled frequency, our method evaluates the entire frequency band continu...

Full description

Summary: Protein knockdown using a zinc finger degron tag and thalidomide analogs was previously considered ineffective in mouse cells. However, using EGFP as an indicator, we found that a super-degron tag (SD) enables degradation in mouse cells when combined with iberdomide or mezigdomide. While SD...

Full description

Summary: A large proportion of human behavior is organized in time in the form of sensorimotor sequences. Learning new behavioral sequences recruits cognitive functions with their neural underpinnings. Here, we characterize how neurophysiological activity revealed in the EEG signal can reflect these...

Full description

Summary: Immune-derived opioid peptides have been implicated in immune regulation and inflammatory processes. Here, we investigate the effects of nociceptin/orphanin FQ (N/OFQ) on metabolic function and inflammation in obesity. Selectively targeting N/OFQ, encoded by the Pnoc gene, in B cells mitiga...

Full description

Summary: Interaction with cannabinoid receptor 1 (CB1) partially determines the bioactivity of the phytocannabinoids. Consequently, there has also been significant effort directed toward preparing synthetic cannabinoids with either enhanced agonistic or antagonistic activity against this receptor. T...

Full description

Summary: In systems exhibiting avalanche-like activity, critical exponents can provide insights into the mechanisms underlying the observed behavior or on the topology of the connections. However, when only a small fraction of the units composing the system are observed and sampled, the measured exp...

Full description

Summary: Renewable energy is pivotal in addressing climate challenges, thereby requiring the systematic quantification of how extreme climate events affect market stability and resilience. Through global analysis, this study demonstrates that 74.51% of extreme climate events exert statistically sign...

Full description

Summary: Neuronal populations in visual cortex integrate stimulus-driven input from the retina with contextual input from neighboring neurons, each targeting distinct cortical layers. Using line-scanning fMRI with precise targeting, we recorded depth-resolved responses in human visual cortex to stim...

Full description

Summary: Omicron has emerged as the most successful variant of SARS-CoV-2. In addition to mutations in Spike that mediate humoral immune escape, the Omicron-specific Envelope (E) T9I mutation has been associated with increased transmission fitness. However, the underlying mechanism remained unclear....

Full description

Summary: This study focuses on the rapid detection of antimicrobial resistance (AMR) in Klebsiella pneumoniae. The “Align-Search-Infer” pipeline aligned query sequences from 24 urine samples against a curated genome database of 40 Klebsiella isolates, searched for the best matches, and inferred thei...

Full description

Summary: Myocardial infarction (MI) is a common cardiovascular disease with a high risk of sudden death. We aim to develop potential and more effective therapeutic strategies for treating and preventing MI. A mouse model of MI was established, and cardiac tissue sample microarray data and GSE236374...

Full description

Summary: The monoclonal antibody CIS43 preferentially binds the junctional region of Plasmodium falciparum circumsporozoite protein (PfCSP) and is highly protective in humans. Here, we develop an in silico pipeline to improve antigen-antibody interaction energies and apply it to CIS43 variants elici...

Full description

The aim of this paper is to present the Report of innovative restoration techniques, technologies and materials used in conservation in the context of natural sciences and heritage science of the RUINS Project. First, the specifics of preservation and maintenance of ruins are briefly described. Subs...

Full description

Summary: A strong interest in drugs targeting the tumor microenvironment (TME) necessitates new experimental systems that incorporate key TME components. Compared to traditional 2D cell lines, 3D ex vivo spheroids from patient-derived xenograft (PDX) materials may better capture patient tumor charac...

Full description

Summary: The human brain microenvironment undergoes dynamic changes during development, which have been incompletely characterized in in vitro models including neural organoids. Here, we used liquid chromatography-mass spectrometry to investigate proteome and secretome changes in human dorsal forebr...

Full description

The history of the development of natural sciences is integrated into the educational process of the relevant disciplines and can influence the formation of a student’s personality. The content and interpretation of the historical component are not regulated, they are included in the “hidden curricu...

Full description

Summary: Most multicellular life reproduces sexually, utilizing a single-celled stage that acts as a genetic bottleneck. This bottleneck limits the evolution of selfish cell adaptations by ensuring all cells descend from a single progenitor. We investigated an obligately asexual strain of Schmidtea...

Full description

Summary: Placenta-targeting nano-drugs have emerged as a safe and effective treatment option for preeclampsia (PE). Downregulation of peroxisome proliferator-activated receptor γ (PPARγ) induces dysfunctional placental trophoblasts and facilitates placental reactive oxygen species, which weakens the...

Full description

Статья посвящена исследованию библиотек XVIII–XIX вв., принадлежавших известным предпринимателям и государственным деятелям Строгановым. Основное внимание уделяется выявлению и изучению естественно-научной литературы европейских авторов в составе библиотеки графа П. А. Строганова по его «Каталогу ро...

Full description