Search Results - "Myositis"

Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of acquired systemic diseases mainly involving skeletal muscles. The main representatives of IIM are polymyositis (PM) and dermatomyositis (DM). Epidemiological surveys demonstrate that there is a relationship between PM/DM and malig...

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The retraspective analysis of blood indices of 524 patients with vanous forms of stæptococcal infections of soft tissues was earned out. 282 of them had erysipelas and. cellulitis, 110 had a purulent cellulitis (erysipelas phlegmoneuse), 321 had necrotizing fasciitis and. myositis. It is established...

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Scrub infection is caused by Orientia tsutsugamushi, due to the bite of a chigger. It has a wide presentation, including febrile illness, ARDS (acute respiratory distress syndrome), and encephalopathy. However, we report a rare case of myositis in Scrub Typhus.

Myositis ossificans (MO) is a self-limiting benign ossification disorder, characterized by heterotopic ossification within skeletal muscles. Pediatric MO cases are rarer, easy to be misdiagnosed. The diagnosis of traumatic MO is based on a thorough history, physical examination, and imaging studies....

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Abstract Objective Immune-related adverse events (irAEs) are recognized in oncology, particularly with immune checkpoint inhibitors and other targeted therapies. Brentuximab Vedotin (BV), is an anti-CD30 antibody–drug conjugate- its association with immune-mediated myositis remains unexplored. We re...

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In juvenile onset systemic lupus erythematosus (SLE), musculoskeletal involvement is one of the most common manifestations. Musculoskeletal symptoms may be due to disease activity itself, organ damage due to SLE activity, drug exposure, or comorbidities. Although they are not life-threatening, they...

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Abstract Inclusion body myositis (IBM) is an inflammatory myopathy that displays proximal and distal muscle weakness. At the histopathological level, the muscles of IBM patients show inflammatory infiltrates, rimmed vacuoles and mitochondrial changes. The etiology of IBM remains unknown, and there i...

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Chickenpox is a common viral infection that mostly affects children from 5 to 9 years old, but it can also occur at any age group. Although typically self-limiting, chickenpox can rarely cause a severe disease and serious complications in approximately 2% of patients. Musculoskeletal complications,...

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The article presents a review of the literature and a clinical observation of a patient with long-term anamnesis of primary Sjögren's syndrome (SS) in combination with sporadic inclusion body myositis (sIBM). The diagnosis of SS was confirmed in accordance with the Russian diagnostic criteria f...

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Objectives: Heterotopic bone formation within a muscle is designated as ‘myositis ossificans’, and it is associated with multiple aetiologies, such as trauma, genetic predisposition, post-infection, or undetermined causes. When the disease develops as a result of a trauma, the myositis ossificans is...

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Objective: Benign acute childhood myositis (BACM) is a self-limiting condition often following viral upper respiratory infections, manifesting with leg pain, difficulty walking, and muscle tenderness. Although the symptoms are distressing, BACM typically resolves without specific treatment, and the...

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Background. Fibrodysplasia ossificans progressiva (FOP) is a genetic disease of the heterotopic ossification group associated with the mutation in ACVR1/ALK2 gene. FOP is characterized by progressive heterotopic endochondral ossification of connective tissue that occurs in postnatal period. It leads...

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Kikuchi-Fujimoto disease (KFD) is a benign, self-limiting histiocytic necrotizing lymphadenitis systemic disorder with unknown etiology. KFD has been known for half a century, but difficulties in distinguishing it remain. Its diagnostic significance is related to the increasing prevalence of KFD wi...

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Anti-Ku antibodies are a special type of myositis-associated antibodies that are characteristic of patients with the overlap syndrome of systemic scleroderma and immune-inflammatory myopathy, as well as occurring in other autoimmune diseases. Patients with these antibodies have their own clinical an...

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Immune checkpoint inhibitors have been used successfully over the last several years for treatment of many types of advanced cancer. Those agents cause uncontrolled activation of the immune system frequently resulting in immune-related adverse effects and exacerbation of pre-existing autoimmune dise...

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ABSTRACT Myositis is a rare (<1%) but potentially severe immune‐related adverse event (irAE) of immune checkpoint inhibitors (ICIs), with a 40%–50% fatality rate. Its incidence and pathology in curative, neoadjuvant settings, particularly with chemoradiotherapy (CRT), remain poorly defined. Given...

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Immune checkpoint inhibitors (ICI) such as cytotoxic T-lymphocyte associated protein-4 (CTLA-4), programmed cell death-1 (PD-1), programmed death ligand-1 (PD-L1), and lymphocyte activation gene-3 (LAG-3) are increasingly used to treat cancer patients since they were shown to reduce tumor progressio...

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Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced cancers like malignant melanoma. However, they can lead to a range of immune-related adverse events (irAEs), impacting various organ systems. Among these, myositis is a rare but serious irAE, typically characterized by...

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This study aims to assess muscle strength recovery in patients with idiopathic inflammatory myopathy (IIM) with three myositis-specific autoantibodies (MSAs). Forty-eight IIM patients (19 with anti-TIF1-γ Ab, 21 with anti-ARS Ab, and 8 with anti-SRP Ab) were included. Physical exercise began one wee...

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