Search Results - "Microbial Biotechnology"

ABSTRACT Shewanella oneidensis, recognised as an important model organism for exoelectrogenic electron transport, has been extensively studied for its potential applications in bioelectrochemical systems. To date, the activity of transposable elements in this organism has not been conclusively inves...

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ABSTRACT The metabolic processes of Bifidobacterium longum subsp. infantis, an early coloniser of the human gut, are essential for gut health, mainly due to the production of indole derivatives from tryptophan. This study investigates the capacity of B. infantis ATCC 15697 to biosynthesise indole‐3‐...

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ABSTRACT Scientific research seeks to extend knowledge and understanding, an activity that perhaps more than any other advances society and humanity. In essence, it is the search for truth. But, because it seeks new knowledge, there is little or no benchmark for appraisal of the plausibility or vali...

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ABSTRACT The transition from a petroleum‐based manufacturing to biomanufacturing is an important step towards a sustainable bio‐economy. In particular, biotechnological processes which use one carbon (C1) compounds as feedstock represent an interesting avenue. Many bacterial species evolved naturall...

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ABSTRACT Ursodeoxycholic acid (UDCA) is widely administered to dissolve gallstones, treat liver disorders and reduce blood cholesterol levels. This study investigated fresh and dried chicken manure as a sustainable bioresource for chenodeoxycholic acid (CDCA), a precursor for the biotechnological pr...

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ABSTRACT Microbial biotechnologies could affect health through multiple pathways, including impacts on food, nutrition, and the physical, economic, and social environment. Health in All Policies is an approach to ensure that plans and policies in all sectors maximise health gains and minimise any he...

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ABSTRACT Early diagnosis of pathogens is key to reducing their spreading and to preventing severe health risks. The COVID‐19 pandemic showed us the need for rapid point‐of‐care tests. Here, we describe the preparation of an amplification master mix for point‐of‐care diagnostics. Therefore, two off‐p...

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ABSTRACT Bifidobacteria are key members of the human gut, especially during infancy. The ability of bifidobacteria to outcompete other members of the microbial communities encountered in this highly competitive human gut environment represents a key example of their evolutionary and ecological succe...

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ABSTRACT The built environments of high‐traffic areas can play a significant role in the transmission of microorganisms and associated infections, sometimes favouring the selection of multidrug‐resistant (MDR) organisms due to the excessive use of conventional disinfectants. Probiotic‐based sanitati...

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ABSTRACT True morels are precious edible and medicinal mushrooms. The sustainable development of morel cultivation necessitates urgent breeding programmes to develop improved varieties or strains. Some soil bacteria, including Pedobacter spp., are recognised as morel's beneficial microbes. In t...

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ABSTRACT Corynebacterium glutamicum serves as a pivotal industrial chassis for biomanufacturing and an ideal model for studying the phylogenetically related pathogen Mycobacterium tuberculosis. Oxidative stress poses a critical challenge to microorganisms during aerobic industrial processes and immu...

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ABSTRACT The gut microbiome plays a crucial role in maintaining intestinal homeostasis and influencing immune‐mediated diseases. Human faecal microbiota transplantation (FMT) is often employed in murine models to investigate the role of human microbes in disease regulation, but methods for effective...

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ABSTRACT Phenazines are bioactive secondary metabolites with antifungal, anticancer, and insecticidal properties, while hydroxylated derivatives often exhibit enhanced bioactivity. 2‐hydroxyphenazine (2‐OH‐PHZ), which is synthesised by the flavin‐dependent monooxygenase PhzO from phenazine‐1‐carboxy...

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ABSTRACT Diazotrophic microbes capture atmospheric nitrogen and convert it into ammonia using the enzyme nitrogenase in a process that provides much of the fixed nitrogen that is required to sustain life in the biosphere. The advent of the Haber Bosch industrial process in the 20th century ushered i...

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ABSTRACT New therapeutics are urgently needed to curb the spread of drug‐resistant diseases. Bioactive peptides (BAPs), including antimicrobial peptides, are emerging as an exciting new class of compounds with advantages over current drug modalities, especially small molecule drugs that are prone to...

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ABSTRACT Enhancing acid tolerance of industrial microorganisms is critical for improving fermentation efficiency and sustainability. This study presents a synthetic biology approach that employs toehold switch‐based acid‐tolerance modules to engineer acid‐tolerant strains. This toehold switch‐based...

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ABSTRACT Strains of Bacillus species, plant growth‐promoting rhizobacteria, have been commercialised as biofertilisers; they are ideal for this because these species form spores that can be stored stably for a long time. However, for these spores to exert their full beneficial effects, they must ger...

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