Suchergebnisse - "Lung function"
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141
Genetically Engineered Biologic Drugs in Management of Children with Bronchial Asthma
Veröffentlicht 2021-12-01“… Two years of anti-IgE treatment experience in inpatient pediatric department settings demonstrates that omalizumab inclusion to treatment of children with severe asthma resistant to standard therapy allows to solve asthma symptoms, to forgo high doses inhaled glucocorticosteroids, to improve lung function parameters, and to increase significantly quality of life in 95% of our patients. …”Current article represents the modern clinical guidelines on management of severe bronchial asthma (BA) in children and practical use of genetically engineered biologic drugs. Clinical efficacy and safety of omalizumab has its special role. Efficacy analysis was carried out in real-life' clinic...
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142
Lung Health of Early COPD (LHEC): A Multi-Center Cohort Study—Rational and Design
Veröffentlicht 2025-07-01“… By setting a narrower range of lung function thresholds to define pre- and mild-COPD, this study will effectively observe the early disease progression of COPD patients in a shorter period of time. …”Wei Li,1 Jieping Lei,1,2 Baicun Li,1,3 Xingyao Tang,1,4 Yaodie Peng,1,5 Ke Huang,1 Ting Yang1 1National Center for Respiratory Diseases; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chine...
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143
Assessment of Preserved Ratio Impaired Spirometry (PRISm) Based on Different Definitions in the Early COPD Cohort
Veröffentlicht 2025-05-01“… Participants identified as PRISm by both definitions exhibited lower lung function, higher airway reactance, and increased airway resistance compared to the control group. …”Cuiqiong Dai,1,* Gaoying Tang,1,* Huajing Yang,1,2,* Fan Wu,1,2 Zhishan Deng,1 Youlan Zheng,1 Ningning Zhao,1 Lifei Lu,1 Qi Wan,1 Zihui Wang,1 Jieqi Peng,1,2 Xiaohui Wu,1 Kunning Zhou,1 Guannan Cai,1 Shan Xiao,1 Xiang Wen,1 Changli Yang,3 Shengtang Chen,4 Shuqing...
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144
Comparative effectiveness of ACE inhibitors spirapril, fosinopril, and enalapril in complex therapy of patients with coronary heart disease, chronic obstructive pulmonary disease,...
Veröffentlicht 2006-06-01“… At baseline and during the treatment, 24-hour blood pressure monitoring was performed, mean pulmonary artery pressure (MPAP), lung function, endothelium-dependent and independent vasoreactivity, hemorheology parameters, and quality of life (QoL) were measured. …”Aim. To study effectiveness of ACE inhibitor therapy in coronary heart disease (CHD) combined with chronic obstructive pulmonary disease (COPD). Material and methods. In total, 89 males with CHD and COPD were examined. All participants had Stage I-II arterial hypertension (AH). For antihypertensive...
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145
Relationship between fractional exhaled nitric oxide, asthma control test, and spirometry measurement in individuals with asthma receiving treatment
Veröffentlicht 2025-07-01“… Additionally, spirometry parameters showed significant improvement after bronchodilator use, but FeNO did not strongly predict lung function improvement. The findings suggest that while FeNO is useful as an indicator of airway inflammation, it may not consistently correlate with functional lung measurements or asthma control as assessed by spirometry and ACT. …”To evaluate the relationship between fractional exhaled nitric oxide (FeNO), asthma control test (ACT), and spirometry measurements in individuals with asthma receiving treatment, a cross-sectional study was conducted involving 47 diagnosed asthmatic patients. FeNO levels were measured using Everse...
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146
Biopersistent granular dust and chronic obstructive pulmonary disease: a systematic review and meta-analysis.
Veröffentlicht 2013-01-01“… <h4>Data sources</h4>Searches of PubMed and Embase for the time period 1970-2010 yielded 257 cross-sectional and longitudinal studies on people exposed to inorganic dust at the workplace with data on lung function. These studies were independently abstracted and evaluated by two authors; any disagreement was resolved by a third reviewer. …”<h4>Objective</h4>Applying a systematic review to identify studies eligible for meta-analysis of the association between occupational exposure to inorganic dust and the development of chronic obstructive pulmonary disease (COPD), and conducting a meta-analysis.<h4>Data sources</...
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147
Using induced sputum method in clinical practice in patients with bronchial asthma
Veröffentlicht 2022-12-01“… The article also presents detailed characteristics of eosinophilic, neutrophilic, mixed and small granulocyte phenotypes of bronchial asthma, and describes the most frequent correlations of phenotypes with the severity and course of the disease, with lung function parameters and other indicators. The paper gives an account of the possibilities of using the induced sputum method for a comprehensive assessment of the course, asthma controllability and the effectiveness of drug therapy, as well as for a personalized selection of an antiinflammatory drug considering the inflammatory phenotype. …”This article presents an overview of modern statements of the induced sputum method; detailed description of the methods and protocols for taking sputum in adults and children, methods for processing the obtained substance. The paper describes in detail the features of the cellular composition of in...
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148
Predictors of extracorporeal membrane oxygenation efficacy in patients with acute respiratory failure
Veröffentlicht 2020-09-01“… The purpose of this article is to describe the problem of predicting the lung function recovery in patients with extracorporeal membrane oxygenation for acute respiratory distress syndrome. …”The purpose of this article is to describe the problem of predicting the lung function recovery in patients with extracorporeal membrane oxygenation for acute respiratory distress syndrome. Data from CESAR and EOLIA clinical trials on the efficacy of extracorporeal membrane oxygenation in patients w...
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149
Сentral heamodynamic сondition and morphological characteristics of lungs at patients with lung cancer depending on components of the infusion-transfusion therapy.
Veröffentlicht 2015-12-01“… The aim of this study is to determine the central hemodynamics parameters depending on the condition of ventilate lung function in thoracic oncology patients during the postoperative period and to determine the morphological features of the lungs that developed under the influence of intraoperative administration of refortan and perftoran. …”Background. Despite the large number of studies devoted to the study of the functional state of the cardiovascular and respiratory systems after operations on the lungs, there are still many issues regarding the mechanisms of hemodynamic disorders in the postoperative period. It stipulates considera...
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150
Relation of Changes in PEF and FEV1 During Salbutamol-Induced Bronchodilation After Methacholine Challenge Test
Veröffentlicht 2025-01-01“… We aimed to use the administration of salbutamol after a methacholine challenge test as a model of bronchodilation to study how accurately the change in PEF predicts improvement in lung function, as defined by an increase in FEV1. We analyzed 869 adult patients who were administered salbutamol after a methacholine challenge. …”Asthma diagnosis can be confirmed by observing significant bronchodilator response (BDR) through peak expiratory flow (PEF) at home or forced expiratory volume in 1 s (FEV1) via spirometry in a clinical setting. We aimed to use the administration of salbutamol after a methacholine challenge test as...
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151
Spirometry and respiratory disease risk factors in firefighters in Almaty
Veröffentlicht 2023-01-01“… Objective: to ascertain respiratory symptoms, lung function and selected respiratory disease risk factors in firefighters of the city of Almaty. …”Objective: to ascertain respiratory symptoms, lung function and selected respiratory disease risk factors in firefighters of the city of Almaty. Materials and methods: N=1379, 91% males, firefighters working in Almaty were recruited at the annual screening, where CAT (COPD Assessment Test) and mMRC...
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152
The Effects of Two Different Intensities of Concurrent Training on Pulmonary Function in Female Patients With Type II Diabetes
Veröffentlicht 2025-07-01“… Purpose: Type 2 diabetes is associated with reduced lung function. The purpose of this study was to investigate the effects of two different intensities of concurrent training on pulmonary function in female patients with type II diabetes. …”Purpose: Type 2 diabetes is associated with reduced lung function. The purpose of this study was to investigate the effects of two different intensities of concurrent training on pulmonary function in female patients with type II diabetes. Methods: 24 women with type 2 diabetes were recruited as vo...
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153
The role of arginine and endothelial nitric oxide synthase in the pathogenesis of Covid-19 complicated by metabolic syndrome
Veröffentlicht 2022-12-01“… Defects in the metabolism of NO cause dysfunction in the pulmonary blood vessels, the level of NO decreases, which leads to impaired lung function and coagulopathy. The review presents possible mechanisms of these disorders associated with ED, the release of eNO synthase, changes in phosphorylation and regulation of enzyme activity, as well as insulin resistance. …”This literature review presents the role of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO), as well as arginine, the enzyme substrate, in the disease of metabolic syndrome and COVID-19 (SARS-CoV-2 virus). Metabolic syndrome is a combination of obesity, insulin resistance, hyperglycem...
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154
The first Russian experience with the endothelin 1 receptor inhibitor traclir used in patients with pulmonary hypertension associated with systemic connective tissue diseases
Veröffentlicht 2011-12-01“… In addition to hemodynamic evaluation, the female patients underwent echocardiography (EchoCG), lung function tests, 6-minute walk test, and blood biochemical study (determination of uric acid levels). …”Objective: to study the efficacy and safety of the endothelin 1 receptor inhibitor traclir in patients with pulmonary hypertension (PH) asso ciated with systemic connective tissue diseases. Subjects and methods. The study include...
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155
Clinical, cardio-hemodynamical, and respiratory effects of ACE inhibitor cilazapril in patients with arterial hypertension and chronic obstructive pulmonary disease
Veröffentlicht 2005-02-01“… To investigate effects of an ACE inhibitor, cilazapril, on daily blood pressure (BP) profile, cardiac morphofunctional parameters, lung function (LF) and quality of life (QoL) in patients with arterial hypertension (AH) combined with chronic obstructive pulmonary disease (COPD). …”Aim. To investigate effects of an ACE inhibitor, cilazapril, on daily blood pressure (BP) profile, cardiac morphofunctional parameters, lung function (LF) and quality of life (QoL) in patients with arterial hypertension (AH) combined with chronic obstructive pulmonary disease (COPD). Material and me...
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156
Efficacy of mindful meditation in adjunct to a pulmonary rehabilitation program in improving functional capacity and quality of life in post-treated pulmonary tuberculosis patients...
Veröffentlicht 2025-08-01“… Background: Post-treated pulmonary tuberculosis (PTB) frequently leads to long-term impairments in lung function, endurance, and mental well-being. Pulmonary rehabilitation (PR) programs aim to restore functional capacity but may not sufficiently address psychological distress. …”Background: Post-treated pulmonary tuberculosis (PTB) frequently leads to long-term impairments in lung function, endurance, and mental well-being. Pulmonary rehabilitation (PR) programs aim to restore functional capacity but may not sufficiently address psychological distress. Mindful meditation, w...
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157
Management of Dysarthria in Amyotrophic Lateral Sclerosis
Veröffentlicht 2025-07-01“… In addition, we discuss the impact of interventions that can improve vocal function and quality of life for patients, such as compensatory speech techniques, surgical options, improving lung function and respiratory muscle strength, and percutaneous dilated tracheostomy, possibly with adjunctive therapies to treat respiratory insufficiency, and finally assistive devices for alternative communication. …”Amyotrophic lateral sclerosis (ALS) stands as the leading neurodegenerative disorder affecting the motor system. One of the hallmarks of ALS, especially its bulbar form, is dysarthria, which significantly impairs the quality of life of ALS patients. This review provides a comprehensive overview of t...
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158
The Efficiency of Epidural Anesthesia and Postoperative Analgesia during Myocardial Revascularization without Extracorporeal Circulation
Veröffentlicht 2010-12-01“… After ACBS, epidural infusion with autoanalgesia improves lung function and tissue perfusion and reduces the duration of respiratory support. …”Objective: to evaluate the efficiency of high thoracic epidural anesthesia (EA) and analgesia during aortocoronary bypass surgery (ACBS) without extracorporeal circulation (EC). Subjects and methods. The study enrolled 93 patients who had undergone ACBS without EC. The patients were randomized to th...
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159
Bronchial asthma and obesity are a pathological tandem: the role of nutrition
Veröffentlicht 2021-07-01“… Adequate intake of vitamins A, C, E leads to a decrease in inflammatory reactions in the bronchial tree, an improvement in lung function indicators, a decrease in exacerbations of bronchial asthma and the frequency of hospitalizations associated with a deterioration in the control of this pathology. …”Recently, the influence of malnutrition on the occurrence and progression of bronchial asthma and obesityhas been increasingly studied. Obesity is a 21st century pandemic. Now, there is evidence of the effect of obesity on the risk of developing bronchial asthma. An increased intake of saturated fat...
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Effect of Multi-Walled Carbon Nanotubes on lung tissue and concentration of enzyme Carbonic anhydrase in the New Zealand white rabbit
Veröffentlicht 2023-01-01“… The exposure with Multi Walled Carbon Nanotubes led to significant increase in the lung weight of all groups by increasing the dose and the exposure period compared with control group, While the effect of carbon nanotubes in the lung function was represented by estimating the concentration of enzyme Carbonic anhydrase in blood serum that led to significant increase in the concentration of the enzyme for all groups compared with control group, And the effect of carbon nanotubes were studied on morphological and histological changes in each of the lung and trachea of exposure rabbit compared with control group, the morphological and histological changes in the lung and trachea of exposure rabbit with MWCNTs after 7 days of exposure, included whiting the upper surface of the lobes, sever infiltration of the mixed inflammatory cells (mono and polymorphonuclear), hyperatrophy of the tissue, muscular hyperatrophy of bronchi and fibrosis of the region, while after 90 days of exposure, the histological change were similar to that occurred after 7 days of exposure but more clear. …”The aim of the present study was to investigate the effect of variable doses of Multi Carbon Nanotubes (MWCNTs) 1,3,5 mg/ml/kg body weight on lung weight and their effect on the concentration of Carbonic anhydrase(CA), morphological and histopathological changes of the males New Zealand white rabbi...
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