Risultati della ricerca - "Lung function"
-
121
Clinical scale to assess of bronchial obstruction severity at preschoolers
Pubblicazione 2018-07-01“...In particular, the decrease in parameters of the function of external respiration is the “gold standard” for assessing the severity. Lung function tests for preschoolers are limited. Clinical respiratory scales may be useful in the evaluation of preschooler. ...”The severity of the disease is the main factor for further treatment. Bronchoobstructive syndrome of children is widespread. Early detection of the disease severity and correct treatment eliminate the clinical manifestation of the syndrome and improve the quality of patients life. Criteria of severi...
Testo
Articolo -
122
Clinical Significance of the 5T;12TG Genotype in Pediatric CFSPID: A Retrospective Study
Pubblicazione 2025-06-01“...No isolates of Pseudomonas aeruginosa were identified. Lung function and pancreatic markers remained normal. ...”<b>Background:</b> One of the most common genetic variants among individuals with cystic fibrosis screen-positive inconclusive diagnosis (CFSPID) is 5T;12TG. Classified as having “varying clinical consequences” (VVCC), it may produce a wide spectrum of CF phenotypes when combined in tran...
Testo
Articolo -
123
Clinical Significance of Lung Microbiota and Experience of the Inhaled Antibacterial Therapy in Children of the Omsk Cystic Fibrosis Center (Сase Series)
Pubblicazione 2018-05-01“...A growth of antibiotic-resistant Pseudomonas aeruginosa from patients with cystic fibrosis decreases a lung function significantly, which requires searching new, up-to-date antibiotics. ...”A growth of antibiotic-resistant Pseudomonas aeruginosa from patients with cystic fibrosis decreases a lung function significantly, which requires searching new, up-to-date antibiotics. Goal. An investigation of clinical and microbiological features of respiratory lesion and an assessment of elimina...
Testo
Articolo -
124
Dipeptidyl peptidase-1 inhibitors in bronchiectasis
Pubblicazione 2025-06-01“...Several phase 2 and one phase 3 trial have now confirmed that DPP-1 inhibitors reduce activity of the NSPs in the airways and have clinical benefits in bronchiectasis including reducing exacerbations and improving other clinical end-points such as quality of life and slowing lung function decline. DPP-1 inhibition may also be a promising treatment avenue in other diseases where neutrophilic inflammation is implicated. ...”Dipeptidyl peptidase (DPP)-1 (also known as cathepsin C) inhibitors are the first disease-specific therapy shown to be effective in bronchiectasis. The mechanism of action of DPP-1 inhibitors is suppression of activity of neutrophil serine proteases (NSPs) by preventing them from being activated dur...
Testo
Articolo -
125
Pro: Clinical remission in asthma – implications for asthma management
Pubblicazione 2025-04-01“...Key indicators of remission include high asthma control, absence of exacerbations and stabilised, or normalised, lung function. However, there is currently no common definition for remission, with various studies using different criteria. ...”Asthma treatment has seen significant advancements over the recent years. However, despite improvements in disease control, some patients continue to experience persistent symptoms and exacerbations, necessitating a deeper understanding of disease mechanisms and optimisation of treatment strategies....
Testo
Articolo -
126
CXCL16/CXCR6 axis arises as a potential peripheral biomarker of early COPD development – results from a pilot study
Pubblicazione 2025-07-01“...Plasma CXCL16 levels were measured by ELISA and lung function by spirometry.ResultsCXCL16 plasma levels and CXCR6 expression on platelets, classical monocytes, B-cells, and leukocyte-platelet aggregates were higher in GOLD 1 patients than in non-smokers and pre-COPD subjects. ...”BackgroundChronic obstructive pulmonary disease (COPD) is mainly caused by long-term exposure to cigarette smoke. Since systemic inflammation is an important component of COPD pathophysiology, its characterization is essential for developing new biomarkers and pharmacological approaches. We have pre...
Testo
Articolo -
127
Comparing a Guideline-Based Mobile Health Intervention Versus Usual Care for High-Risk Adolescents With Asthma: Protocol of a Randomized Controlled Trial
Pubblicazione 2025-07-01“...In-person visits will measure the ACT score, lung function, and self-efficacy; telephone visits will measure the ACT score. ...”BackgroundMobile health (mHealth) technology has the ability to integrate personalized health management into patients’ daily routines. In prior investigations of mHealth apps for asthma, patient satisfaction and acceptability have been high. However, rigorous randomized cont...
Testo
Articolo -
128
Role of Digoxin in Preventing Cigarette Smoke-Induced COPD via HIF-1&alpha; Inhibition in a Mouse Model
Pubblicazione 2025-05-01“...Moreover, digoxin inhibited CS-induced inflammatory responses, lung function decline, and mucus hyper-secretion in COPD mouse model. ...”Kedong Zhang,1,&ast; Feng Zhou,1,2,&ast; Caixia Zhu,3 Liang Yuan,4 Defu Li,4 Jian Wang,4 Wenju Lu4 1Department of Pulmonary and Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2Department of Respiratory and Critic...
Testo
Articolo -
129
Role of PI3K/AKT/mTOR signaling pathway and sirtuin genes in chronic obstructive pulmonary disease development
Pubblicazione 2023-09-01“...A significant genotype-dependent variation of lung function parameters was observed for SIRT1 (rs3818292), SIRT3 (rs3782116), PIK3R1 (rs3730089), and MTOR (rs2536). ...”Chronic obstructive pulmonary disease (COPD) is a multifactorial disease of the respiratory system which develops as a result of a complex interaction of genetic and environmental factors closely related to lifestyle. We aimed to assess the combined effect of the PI3K/AKT/mTOR signaling pathway (PIK...
Testo
Articolo -
130
EARLY ECHOCARDIOGRAPHIC MARKERS OF STRUCTURAL AND FUNCTIONAL RIGHT VENTRICULAR REMODELLING IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Pubblicazione 2012-06-01“...All participants underwent echocardiography (EchoCG) and the assessment of lung function (LF). Results. COPD patients demonstrated an early increase in anterior RV wall thickness and RV chamber volume, already at the stage of moderate elevation in pulmonary artery systolic pressure. ...”Aim. To study right ventricular (RV) structure and function, as well as cardiac and pulmonary hemodynamic parameters, in patients with chronic obstructive pulmonary disease (COPD) of moderate severity. Material and methods. The study included 37 COPD patients and 20 healthy controls. All participant...
Testo
Articolo -
131
Association between pulmonary function and carotid intima-media thickness in chronic obstructive pulmonary disease
Pubblicazione 2025-06-01“...Conclusion: The results indicated an inverse association between carotid IMT and lung function test in COPD patients....”Background: Studies have shown that carotid intima-media thickness (CIMT) is an indicator of cardiovascular events and mortality and its increase has correlation with severe airflow obstruction in patients with COPD. The aim of this study was to investigate the association between pulmonary function...
Testo
Articolo -
132
Clinical Efficacy and Safety of Ivacaftor/Lumacaftor Combination in Patients with Cystic Fibrosis: International Studies Review
Pubblicazione 2021-12-01“...It was shown that Iva/Lum increases lung function, reduce the number of acute conditions of bronchopulmonary process (including those that require antibiotics and hospitalization), partially restores pancreas exocrine function, increases body weight and mass growth index, and improves quality of life. ...”Cystic fibrosis is an autosomal recessive disease caused by structure abnormalities in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. It is characterized by severe course and poor prognosis without or with insufficient treatment. Approval of pathogenetic therapy medications, CF...
Testo
Articolo -
133
Non-pharmacologic Prevention of Acute Exacerbation Chronic Obstructive Pulmonary Disease
Pubblicazione 2025-07-01“...Lung volume reduction, through both surgical and bronchoscopic methods, has shown promise in select patient groups, leading to improved lung function and reduced exacerbation risk. Smoking cessation remains a critical intervention, while the role of electronic cigarettes remains debatable; some evidence suggests they may help patients unable to quit tobacco smoking. ...”Chronic obstructive pulmonary disease (COPD) is a major global health issue, as acute exacerbation COPD (AECOPD) significantly worsens outcomes and increases healthcare burden. This review explores non-pharmacologic strategies to prevent AECOPD. Pulmonary rehabilitation consistently demonstrates its...
Testo
Articolo -
134
ANTI-IGE THERAPY FOR SEVERE ASTHMA IN CHILDREN: TWO-YEAR TRIAL
Pubblicazione 2010-05-01“...Thanks to treatment, lung function parameters improve, particularly in children with low bronchial patency parameters even after administration of broncholytics. ...”The article summarizes a two-year experience of treating children and adolescents with severe uncontrolled atopic asthma using Omalizumab. This treatment facilitated to achieve full asthma control in 70% of patients and partial control in 30% of patients. Anti-Ig Etherapy contributes to reduce the f...
Testo
Articolo -
135
Characteristics of epidemiological and molecular relationships between allergic diseases and helminth disorders in Opisthorchis endemic region
Pubblicazione 2008-12-01“...An association of opisthorchis invasion with the improvement of lung function signs and bronchial hyperreactivity was found. ...”To elucidate the molecular mechanisms of O. felineus impact into phenotypic variability of allergic diseases in the opisthorchis endemic region, we studied 104 patients with opisthorchosis, 92 patients with atopic bronchial asthma, 52 patients with a combination of both diseases, and 120 healthy per...
Testo
Articolo -
136
Importance of early diagnostics of chronic obstructive pulmonary disease in patients with coronary heart disease
Pubblicazione 2011-06-01“...The study results support the use of lung function assessment in smoking CHD patients, to diagnose co-existing COPD....”Aim. To study the specific clinical features in patients with coronary heart disease, CHD (stable effort angina, SEA) and chronic obstructive pulmonary disease (COPD), in order to improve early diagnostics of this combined pathology. Material and methods. The study was a retrospective analysis of 95...
Testo
Articolo -
137
Pulmonary hypertension: current issues of diagnosis and treatment
Pubblicazione 2011-03-01“...The 3rd step means clinical class determination on the basis of lung function tests, ventilation-perfusion scan, CT and angiopulmonography. ...”Pulmonary hypertension (PH) is the group of diseases characterized by progressive increase of pulmonary vascular resistance leading to right heart failure and premature death of patients. This review represents the modern clinical and functional classifications, diagnostic algorithm with four main s...
Testo
Articolo -
138
Effects of respiratory physiotherapeutic interventions on pulmonary mechanics, vital parameters and pain in newborns: A systematic review
Pubblicazione 2025-06-01“...Further clinical trials are encouraged to assess lung function more comprehensively. Future studies should include short- and long-term evaluations of lung mechanics, respiratory distress, and pain....”# Objective To evaluate the effects of conventional and non-conventional respiratory physiotherapy on pulmonary mechanics, vital parameters, and pain in newborns admitted to a neonatal intensive care unit. # Methods and Analyses Databases including PubMed, LILACS, SciELO, Science Direct, Cochrane...
Testo
Articolo -
139
Effectiveness of the long-term therapy with bronchodilators, fenspiride and an ACE inhibitor perindopril among patients with chronic obstructive pulmonary disease and chronic cor p...
Pubblicazione 2010-10-01“...In COPD and CCP patients, long-term therapy with bronchodilators and fenspiride was associated with a significant decrease in bronchial obstruction syndrome severity, a substantial improvement in lung function (LF) and physical capability, and some improvement in EchoCG parameters, but did not influence mortality and chronic heart failure (CHF) progression. ...”Aim. To compare clinical effectiveness of the long-term ambulatory therapy (bronchodilators; bronchodilators and fenspiride; bronchodilators, fenspiride and an ACE inhibitor perindopril) among patients with chronic obstructive pulmonary disease (COPD) and chronic cor pulmonale (CCP). Material and me...
Testo
Articolo -
140
MODERN APPROACH TO ASSESS THE ASTHMA CONTROL AND TREATMENT EFFICASY IN DIFFERENT PHENOTYPES BY ENDOTHELIAN DISFUNCTION
Pubblicazione 2017-03-01“...But in patients with persistent symptoms and/or without lung function improvement the level of the endothelin-1 was not decreased significantly. ...”The aim of this study is to measure the level of the endothelin-1 in blood samples and to assess vasoactive function of the endothelial in asthma patients with different phenotypes and to develop the methods of the objective assess of the ongoing treatment. Materials and methods. 119 asthma patients...
Testo
Articolo