Search Results - "Insights"

Background: Chronic non-specific low back pain (CNSLBP) is a debilitating condition with unclear underlying mechanisms. The presence of systemic biomarkers associated with inflammation in nonspecific low back pain (NSLBP) has been inconsistently reported primarily through invasive blood sampling. Ob...

Full description

Well-being plays a critical role in student performance and engagement. The purpose of this pilot study is to describe an active and experiential learning activity and examine its effect on promoting well-being in a convenience sample of graduate students. The results of this study demonstrated that...

Full description

Abstract Objectives To compare the image acquisition time, total examination time, image quality, and technical reliability of three free-breathing MRCP techniques: BioMatrix-triggered (BM-MRCP), respiratory-gating triggered using respiratory bellows (RG-MRCP), and navigator-triggered (NT-MRCP). Met...

Full description

Background: Demyelination and remyelination are major issues for scientists dealing with myelin disorders in both clinical and research fields. Despite that, rapid, reliable and convenient tools to monitor myelin changes still lack both in central and peripheral nervous system. Given that myelin is...

Full description

M1-polarized macrophages exhibit remarkable resistance to ferroptosis, a form of regulated cell death driven by excessive lipid peroxidation. Yet the underlying mechanisms remain to be defined. Through CRISPR-based functional screen of metabolic genes combining transcriptomics analysis, we herein id...

Full description

Electrophysiological data support the notion that spatial and temporal coordination between the forelimbs in primates takes place in a wide network of cortical and subcortical brain structures. However, single neuron electrophysiology is biased towards large, long distance projecting neurons. The ai...

Full description

Abstract Measuring the value that radiology brings to patient care can be challenging. A positive patient experience is consistently associated with patient safety, clinical effectiveness, and outcome measures and is therefore a tool for measuring value-based care. Monitoring the experience of users...

Full description

Abstract Objectives To present an accurate machine-learning (ML) method and knowledge-based heuristics for automatic sequence-type identification in multi-centric multiparametric MRI (mpMRI) datasets for prostate cancer (PCa) ML. Methods Retrospective prostate mpMRI studies were classified into 5 se...

Full description

Abstract Purpose To develop a radiomics model to predict lymph nodes metastasis (LNM) in patients with pancreatic ductal adenocarcinoma (PDAC) and assess its value for clinical management. Methods Patients with pathologically confirmed PDAC from four centers were retrospectively enrolled and split i...

Full description

Abstract Objectives To develop a deep learning model based on Residual Networks (ResNet) for the automated and accurate identification of contrast phases in abdominal CT images. Methods A dataset of 1175 abdominal contrast-enhanced CT scans was retrospectively collected for the model development, an...

Full description

Background: Cancers cause changes in the levels of inflammatory cytokines by inhibiting or promoting their production thus affecting the immune system. The measurement of serum levels of cytokines may be useful in assessing these immunological changes and invariably assessing cancer status. Objectiv...

Full description

Abstract For over 20 years, the two key tenets of adrenal incidentaloma (AI) evaluation have been the upper threshold of 10 Hounsfield units (HU) on noncontrast CT (ncCT) to delineate benignity, and the utilisation of adrenal washout CT (AWCT) to evaluate those above this cutoff. In light of growing...

Full description

<b>Background/Objectives</b>: Alcohol-related liver disease (ARLD) is a major cause of chronic liver disease, yet its clinical profile in Albania, a region with high HBV prevalence and rising alcohol consumption, remains poorly characterized. This study evaluates the clinical markers of...

Full description

Aging is characterized by a progressive decline in organ and tissue structure and function, significantly increasing the risk of many chronic diseases. Developing interventions to delay aging holds the potential to reduce the burden of age-associated diseases and promote healthy longevity. Gene ther...

Full description

Glioma, the most common primary intracranial tumor, has seen increased scrutiny with the advent of high-throughput detection technologies, yet many aspects of its tumorigenesis and progression remain enigmatic. In this study, we utilized 4D label-free mass quantitative proteomics to analyze glioma p...

Full description