Search Results - "GWAS"

Lipopolysaccharide (LPS) endotoxin is a well-characterized microbe-associated molecular pattern (MAMP) that forms the outer membrane of both pathogenic and commensal Gram-negative bacteria. It plays a crucial role in triggering inflammatory disorders such as mastitis, acidosis, and septicemia. In he...

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The local goat breeds of Chongqing represent the typical goat populations of Southwestern China and play a significant role in global goat research. However, studies on these goats remain limited. Chongqing goats exhibit diverse coat colors, a crucial economic trait essential for individual and bree...

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The increasing availability of Single Nucleotide Polymorphisms (SNPs) discovered by Next Generation Sequencing will enable a range of new genetic analyses in crops, which was not possible before. Concomitantly, researchers will face the challenge of handling large data sets at the whole-genome level...

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<b>Background/Objectives</b>: The INK4 locus at chromosome 9p21.3, encoding CDKN2A, CDKN2B and the long non-coding RNA CDKN2B-AS1 (ANRIL), has been implicated in multiple diseases, including glaucoma and cardiovascular disease. ANRIL plays a critical role in gene regulation, inflammation...

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Potato (Solanum tuberosum L.) is one of the most important food crops in the world. The genome of this potato species is autotetraploid and has a high level of heterozygosity, also this potato species is a cross-pollinated plant. These characteristics complicate the genetic analysis and breeding pro...

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Milling and appearance quality are important contributors to rice grain quality. Abundant genetic diversity and a suitable environment are crucial for rice improvement. In this study, we investigated the milling and appearance quality-related traits in a panel of 200 japonica rice cultivars selected...

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Low nitrogen (LN) stress is a major limiting factor affecting crop growth and productivity. Understanding the genetic basis of LN tolerance is essential for improving nitrogen use efficiency in Brassica napus. A genome-wide association study (GWAS) was conducted on a panel of 275 B. napus accessions...

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The yak is a vital livestock resource on the Qinghai–Tibet Plateau, renowned for its strong disease resistance and high-quality meat. However, various diseases pose significant threats to its health and lead to substantial economic losses. Current feeding management practices, along with available d...

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Poplar is a promising resource for wood production and the development of lignocellulosic biomass, but currently available varieties have not been optimized for these purposes. Therefore, it is critical to investigate the genetic variability and mechanisms underlying traits that affect biomass yield...

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As a Chinese indigenous chicken breed, Beijing You Chicken is renowned for its high-quality meat and eggs, as well as distinctive morphological features including feathered shanks, beards, and crests. In this study, in order to understand the genetic basis for growth traits of this breed, we perform...

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Cengizhan Acikel,1 Yesim Aydin Son,2 Cemil Celik,3 Husamettin Gul4 1Department of Biostatistics, Gulhane Military Medical Academy, 2Department of Health Informatics, Graduate School of Informatics, Middle East Technical University, 3Department of Medical Psychiatry, 4Department of Medical Informati...

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Chickpea is the second most important legume crop, which is used as a food by people in different parts of the world due to its high nutritive value. Omics technologies have revolutionized the characterization of chickpea genetic diversity by considering single-nucleotide polymorphisms, while struct...

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Glycosylation is an important protein modification, which influences the physical and chemical properties as well as biological function of these proteins. Large-scale population studies have shown that the levels of various plasma protein N-glycans are associated with many multifactorial human dise...

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Blood composition is indicative of health-related traits such as immunity and metabolism. The use of molecular genetics to investigate alterations in these attributes in laying ducks is a novel approach. Our objective was to employ genome − wide association studies (GWAS) and haplotype − sharing ana...

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Chengkou mountain chicken, a Chinese indigenous breed, exhibits unique flavor characteristics. However, the genetic basis of its flavor precursor substances remains unexplored. We performed a genome-wide association study (GWAS) using low-coverage whole-genome sequencing (lcWGS) and genotype imputat...

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Pre-harvest sprouting (PHS) poses a significant global challenge to cereal production, impacting both yield and quality. In this study, we employed genome-wide association studies (GWAS) on diverse rice accessions to identify novel PHS-associated haplotypes. An assessment of 127 cultivated accession...

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Abstract Background The neuroimmune interaction mechanisms of neurodegenerative diseases have received increasing attention. Parkinson's disease (PD) is the second most common neurodegenerative disease, with potential immunoregulatory abnormalities. However, the causal roles of specific immune...

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Objective: Current research links cytokines to cancer occurrence and development. This study used Mendelian randomization (MR) to examine the causal relationship between circulating cytokines and Myelodysplastic syndrome (MDS) onset. Methods: We analyzed 91 circulating cytokines as exposures and MDS...

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Extracellular proteases are a class of Staphylococcus aureus virulence factors that thwart the immune system, promote nutrient acquisition, and shape the activity of virulence determinants. S. aureus displays considerable phenotypic and genotypic variation within clinically important lineages, givin...

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