Search Results - "Fibrosis"

Aim of review. The prognosis and management approach for chronic liver diseases of any etiology in many respects are determined by stage and extent of fibrosis which reflects activity, spread and duration of liver disease. Aim of current publication was to highlight these issues.Summary. Investigati...

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Aim of investigation: The aim of the present study was to evaluate the possibility using of indirect liver fibrosis markers for the estimation of fibrosis severity and timely prescribing of antiviral therapy in patients with chronic hepatitis B.Materials and methods: We examined 130 patients with ch...

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<b>Background/Objectives</b>: Preclinical models of liver fibrosis only partially mimic human disease processes. Particularly, traditional transforming growth factor beta 1 (TGFβ1)-induced hepatic stellate cell (HSC) models lack relevant processes, including hypoxia-induced pathways. Her...

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This review summarizes current data on the pathogenetic mechanisms of fibrosis in chronic liver diseases. Controlled inflammation and transdifferentiation of hepatic stellate cells into myofibroblasts is a key element of fibrogenesis, however, further study of the role of each of the macrophage popu...

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End-stage masticatory muscle fibrosis may occur following trauma, resulting in the inability to open the mouth for eating, drinking, panting and vomiting. Following MRI and EMG confirmation of end-stage muscle fibrosis, a bilateral wedge ostectomy was performed of the mandibles, leaving a permanent...

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Atrial fibrillation (AF) is a complex arrhythmia driven by intricate pathophysiological mechanisms, with atrial fibrosis and inflammation emerging as central players in its initiation and perpetuation. Key pathways, including the renin-angiotensin-aldosterone system (RAAS), TGF-β/Smad signaling, and...

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Background : Rhodamine B dye is available in the market for the textile industry. This substance is often misused as a food coloring and cosmetics in many countries. This substance is most dangerous when consumed can cause disturbances in the function of organs, in the long term could be carcinogeni...

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Aim of investigation. To determine potential of non-invasive ultrasound techniques of fibroelastometry (FEM) and Acoustic Structure Quantification (ASQ) at liver parenchyma assessment and fibrosis stage grading in children with cystic fibrosis (CF).Material and methods. Overall 89 children in the ag...

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Introduction: Oral Submucous Fibrosis (OSMF) is slowly progressing chronic mucosal disease that can affect any part of the oral mucosa, even the pharynx. The soft palate and uvula also undergo significant fibrosis. Materials and Methods: A total number of 200 patients (study and control groups with...

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IntroductionDecline in kidney function due to renal fibrosis is a potential side effect in patients with neuroendocrine neoplasm (NEN) undergoing Peptide Receptor Radionuclide Therapy (PRRT). We aimed to investigate the potential of circulating fibrosis markers reflecting formation and degradation o...

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Extracellular Vesicles (EVs), released by all cell types and detectable in biological samples, carry a variety of biological molecules. These molecules mediate communication and signaling with both local and distant cells, potentially playing a role in the pathogenesis of diseases, including Interst...

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Introduction. The prevalence of interstitial lung diseases (ILD) has been steadily increasing in recent decades both in the world and in Ukraine. Given the heterogeneity of ILDs, the complexity of their diagnosis and treatment, this problem is one of the most relevant for specialists in the field o...

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The aim of the publication. The «Clinical discussion» section will present clinical cases of the Vasilenko Clinic of internal diseases propedeutics, gastroenterology and hepatology, Sechenov First Moscow state medical university. Each clinical case is accompanied by the comments reflecting stepwise...

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Fibrosis is one of the causes of kidney allograft loss, especially late after transplantation (up to 65% incidence after 2 years). The purpose of this literature review is to analyze studies examining noninvasive monitoring techniques for renal graft fibrosis.

It is known, that preservation of ligamentum flavum while microdiscectomy allows to improve results of treatment in patients with lumbal intervertebral disk herniations, promoting prevention of epidural fibrosis that may cause failed back syndrome. Microdiscectomy with flavopreservation with the hel...

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Massive Ovarian Oedema (MOE) is a rare gynaecological disorder that has been rarely reported in our country. Approximately six cases have been reported previously in India. The lesion may either present as a primary disease or develop secondarily, subsequent to an ovarian lesion or pregnancy. Moreov...

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Latar belakang: Fibrosis hepar merupakan salah satu bentuk degenerasi hepar, dan apabila dibiarkan dapat berkembang menjadi sirosis. Salah satu stimulus yang dapat menyebabkan fibrosis adalah dietilnitrosamin, yang dimetabolisme menjadi radikal bebas seperti Reactive Oxygen Species (ROS), yang dapat...

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Pulmonary fibrosis due to COVID-19 is recognized as sequel of ARDS characterized by failed alveolar re-epithelization, fibroblast activation, excessive collagen deposition and other extracellular matrix components that disrupt the normal lung architecture. There are risk factor for pulmonary fibros...

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Summary: Hepatic stellate cells (HSCs) play a central role in the development of liver fibrosis. We previously showed that fibroblast growth factor 18 (FGF18) promotes liver fibrosis by increasing HSC proliferation. However, the underlying mechanisms remain incompletely understood. Here, we showed t...

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La foliculitis decalvante es una variante rara de las alopecias cicatriciales primarias neutrofílicas, que cursa con áreas de alopecia cicatricial central y folículos en penacho rodeadas por pústulas foliculares recurrentes en la periferia; afectan principalmente el vértice y la región temporoparie...

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