Search Results - "Cancer Cell International"

Abstract GSDMB, a key protein in pyroptosis, is closely linked to various diseases. Nanomaterials can target and regulate specific pathways. Herein, we report a simple and efficient one-step method to develop multi-enzyme nanoparticles capable of suppressing GSDMB expression. 0.5ZnO@Cu5.4O can inhib...

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Abstract Regular and consistent physical activity significantly reduces the risk of colorectal cancer (CRC) by approximately 24% in men and 23% in women. There are several mechanisms through which exercise can help protect against CRC. For example, it can reduce chronic inflammation, boost the immun...

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Abstract Background Protein palmitoylation is a reversible post-translational modification that increases protein hydrophobicity, which can affect protein localization, stability, and function. Although palmitoylation is frequently observed in various cancers, the specific mechanisms by which it inf...

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Abstract This review examines the growing role of exosomes and circulating exosomal biomarkers in predicting response to immune checkpoint inhibitors (ICIs) in cancer therapy. While ICIs have revolutionized cancer treatment, predicting patient response remains a major challenge. Exosomes, small extr...

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Abstract Objective To examine the impact of different intestinal microbiota conditions on the absorption of couplet medicines (dried toad skin and radix clematidis) into the bloodstream, and to evaluate the therapeutic effects of drug-containing plasma, produced under different intestinal microbiota...

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Abstract Background Existing staging approaches fall short in precisely forecasting the likelihood of recurrence and survival outcomes among patients undergoing surgery for early-stage breast cancer (EBC). Our study hypothesized that multivariate long non-coding RNA (lncRNA) expression profiles, whe...

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Abstract Background ADAMTS2 is a metalloproteinase known to be implicated in collagen maturation and regulation of (lymph)angiogenesis. As these properties are likely to alter tumor progression, we aimed to assess the overall impact of ADAMTS2 on cancer development. Methods and results Using publicl...

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Abstract YOD1 (OTUD2) is a pivotal deubiquitinating enzyme (DUB) of the Otubain family. It plays an essential role in protein degradation and the regulation of cell signal transduction, influencing various biological processes. The activity of YOD1 is mediated through its three structural domains: t...

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Abstract Background The high heterogeneity and multi-directional poor differentiation of tumor cells in mesothelioma (MESO) contributes to tumor growth and malignant biological behaviors. However, a molecular classification based on differentiated states of tumor cells remains void. Methods We perfo...

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Abstract Background ACK1, a non-receptor tyrosine kinase, phosphorylates various substrates involved in cancer progression. Its oncogenic activity is driven by gene amplification, mutations, and post-translational modifications. However, additional regulatory mechanisms that govern ACK1 activity rem...

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Abstract Background Clear cell renal cell carcinoma (ccRCC) is one of the most common malignant tumors of the urinary system. Protein acetylation plays a key role in regulating cellular processes and cancer signaling pathways. This study explores the potential biological mechanisms of ccRCC from the...

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Abstract Background Lung cancer, one of the most prevalent and deadly malignant tumors, is increasingly common globally in terms of both morbidity and mortality rates. Unlike pyroptosis and necroptosis, cuproptosis is a non-apoptotic programmed cell death process. Studies have demonstrated that cupr...

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