Rezultaty - "Brigham and Women's Hospital"

Objective: Intra-articular injections (IAI) are commonly used to treat knee pain in persons with knee osteoarthritis (OA). We sought to determine the value of commonly used IAIs in knee OA management. Methods: We used the validated Osteoarthritis Policy Model (OAPol) to assess the value of saline, c...

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Damage to the articular cartilage of the tibial plateau presents significant challenges, resulting in pain, functional impairment, and progressive joint degeneration that can lead to severe osteoarthritis. Traditional open surgeries, although effective, are associated with substantial tissue disrupt...

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In regenerative medicine, effective management of tissue ischemia in surgical skin flaps is crucial, yet challenging, particularly because inadequate blood flow often leads to necrosis at the distal flap tips. This study aimed to examine the therapeutic potential of catalase-coated oxygen-generating...

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ABSTRACT Nicotinamide adenine dinucleotide (NAD+) plays an important role in the innate immune response and is depleted during SARS‐CoV‐2 infection due to increased turnover. It is unknown whether treatment with NAD+ precursors can safely raise NAD+ levels in patients with COVID‐19. To determine whe...

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Background: Traumatic spinal cord injury (SCI) remains a devastating condition, with limited functional recovery despite advancements in clinical management and understanding of its mechanisms. SCI pathophysiology involves primary mechanical trauma and secondary neuroimmune and structural changes, l...

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Background: The purpose was to identify the effects of mental health on postoperative outcomes following arthroscopic labral repair. It was hypothesized that low preoperative mental health, measured by the Veterans RAND 12-Item Health Survey Mental Component Score (VR-12 MCS), would demonstrate infe...

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Background: Anemia is common in critically ill patients and is associated with poor outcomes. We investigated the prevalence of anemia and its association with in-hospital outcomes among patients admitted to cardiac intensive care units (CICUs) and subgroups within this population. Methods: The Crit...

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IntroductionSleep dysregulation is highly prevalent in pediatric chronic pain conditions and associated with poorer clinical outcomes. Interactions between underlying circadian misalignments and pain in pediatric populations remain unclear. Dim-light melatonin onset collections conducted in external...

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Retinopathy of prematurity (ROP) with early vessel loss (Phase I) followed by uncontrolled vessel growth (Phase II) causes visual impairment in premature infants. Although supplementation with omega-3 (n-3) docosahexaenoic acid (DHA) alone shows mixed results in preventing ROP, supplementation with...

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Abstract The overlap syndrome (OVS), defined as coexisting chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), is linked to worse outcomes than either condition alone. Patients with COPD and OSA may have fewer obstructive events, but underlying mechanisms remain unclear....

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ABSTRACT Background Estimated plasma volume status (ePVS) correlates with intravascular congestion and prognosis in patients with heart failure. The ePVS relationship with invasive hemodynamic profiling and clinical outcomes in patients with liver cirrhosis (LC) remains unclear. Methods This single‐...

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Background: Patients with chronic limb threatening ischemia (CLTI) are at risk for major adverse cardiovascular events (MACE), yet few tools exist for risk stratification. Objectives: The purpose of this study was to derive and validate a CLTI MACE risk prediction model. Methods: Participants in the...

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Abstract Background Video review is widely recognized as an effective method for teaching communication; however, it can increase educators' workload and learners' stress. Methods We utilized Tsucom, an online platform developed by BonBon, Inc., which enables asynchronous video communicati...

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Background: Coronary artery disease (CAD) results in substantial morbidity and mortality. Objectives: The purpose of this study was to develop a deep learning model to detect CAD defined using diagnostic codes (“ECG2CAD”) and identify people at risk for adverse events using electrocardiograms (ECGs)...

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Abstract The gastrointestinal tract can be deranged by ailments including sepsis, trauma and haemorrhage. Ischaemic injury provokes a common constellation of microscopic and macroscopic changes that, together with the paradoxical exacerbation of cellular dysfunction and death following restoration o...

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Abstract Promising therapeutic interventions that target the underlying pathophysiology are changing the landscape of Alzheimer's disease (AD) research. The AD care pathway must be transformed to meet the challenge of bringing these new therapies to the increasing number of people living with A...

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