Search Results - "Biomarker"

ABSTRACT Biomarkers play a pivotal role in the detection and management of diseases, including obesity—a growing global health crisis with complex biological underpinnings. The multifaceted nature of obesity, coupled with socioeconomic disparities, underscores the urgent need for precise diagnostic...

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ObjectiveColorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, emphasizing the need for noninvasive and reliable diagnostic tools. Circulating microRNAs (miRNAs) have emerged as promising liquid biopsy biomarkers for CRC detection. This meta-analysis aimed to evaluat...

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Pancreatic cancer is one of the highly malignant cancers that have poor prognosis and limited treatment options. The development of targeted therapies is important for improving patient outcomes. In this study, we analyzed the datasets from the GEO database to identify potential mRNA biomarkers for...

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«Omic» biomarkers are promising tools for personalizing pharmacotherapy, including and mental illness because allow predicting an individual profile of the effectiveness and safety of psychotropic drugs. «Omics» biomarkers include pharmacogenomic, pharmacoproteomic, pharmacotranscriptome, pharmacome...

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Background: Adenomyosis is a gynecological disorder characterized by the presence of endometrial tissue within the myometrium, with incidence rates ranging from 10–65% among women of reproductive age. Objective: This study utilized transcriptomic analysis to identify significant biomarkers assoc...

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Chemical risk assessment can benefit from integrating informative biomarkers in human biomonitoring (HBM). Beyond exposure biomarkers, effect biomarkers inform on biological reactions in the body, potentially leading to adverse effects, while susceptibility biomarkers address inter-individual variab...

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Lung adenocarcinoma (LUAD) demonstrates pronounced female predominance and escalating incidence, yet sex-specific environmental determinants remain poorly characterized. This study elucidates cadmium (Cd)-associated molecular mechanisms driving female LUAD pathogenesis through integrated epidemiolog...

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Background: Endometriosis is among the leading causes of morbidity in the female population worldwide. Currently, the definite diagnosis of endometriosis depends on laparoscopy as the gold-standard method. Potential biomarkers, such as inflammatory biomarkers, cancer antigens, and hormones, offer no...

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BackgroundWe conducted this systematic review to present high-quality evidence on the prognostic ability of CRP, albumin, and lymphocyte (CALLY) index for gastrointestinal (GI) malignancies.MethodsPubMed, Embase, Scopus, Web of Science, and Wanfang databases were searched till 15th January 2025 for...

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Abstract MicroRNAs are non-coding RNAs, playing an important role in regulating many biological pathways, such as innate immune response against various infections. Different studies confirm that many miRNAs act as important regulators in developing a strategy for the survival of Mycobacterium tuber...

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Aims: To date, ESR1 activating mutations acts as key player to clinically stratify estrogen receptor (ER)+/HER2-advanced breast cancer (BC) patients eligible to novel new generation oral Selective Estrogen Receptor Degraders (SERD) relapsing after first line aromatase inhibitors. Liquid biopsy repre...

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Background: Brain-derived neurotrophic factor (BDNF) plays a pivotal role in neuroplasticity and cognitive development. While exercise has been shown to modulate BDNF levels in adults, evidence in children remains limited and heterogeneous. Methods: A systematic review was conducted following PRISMA...

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Background and purpose: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the central nervous system. It remains unclear whether pathological changes in ALS can lead to abnormalities in neural dynamics and how these abnormalities relate to key clinical characteristics of AL...

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Aim of the work: to evaluate urinary CD163 as a possible biomarker indicating activity of lupus nephritis (LN). This retrospective, cross-sectional study evaluated 68 patients diagnosed with systemic lupus erythematosus (SLE) over a year, focusing on different states of lupus nephritis (LN). Partici...

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лукиан самосаткийThe search and application of genetic prognostic and predictive biomarkers in colorectal cancer (CRC) are aimed at identifying the characteristics of colorectal tumors for choosing a therapy strategy. The review is devoted to summarizing the achievements in scientific and clinical r...

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ObjectiveThe prognostic role of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score in non-small cell lung cancer (NSCLC) has been widely reported, but the results remain controversial. Therefore, we aim to evaluate the prognostic and clinicopathological value of the HALP score in NSCLC t...

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Objective To develop an effective new method for early detection of pancreatic cancer biomarkers and to aid early clinical diagnosis.Methods A DNA probe (Probe) capable of specifically recognizing the target miRNA was designed. The specific probe of miRNA 21 is designed first, and then mixed with th...

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Infectious diarrhea takes a leading position in all infectious diseases  worldwide. As a result of the pathogens diversity, patient-specific  diagnosis and treatments are needed. Additional laboratory tests are crucial for differentiation among pathogens, as routine  bacteriological and virological ...

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Sepsis remains a global health emergency, demanding timely and accurate diagnostics to reduce morbidity and mortality. This review critically assesses the recent progress (2020–2025) in the development of electrochemical aptamer-based biosensors for sepsis detection. These biosensors combine aptamer...

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