Risultati della ricerca - "Frontiers in Allergy"

BackgroundComorbid allergic rhinitis and constipation (ARFC) in children are associated with gut microbiota (GM) dysbiosis and metabolic perturbations; however, the underlying mechanistic interplay remains unclear.ObjectiveThis multi-omics study aimed to characterize GM and fecal metabolomic signatu...

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BackgroundSmall airway function naturally declines with aging. However, the precise age this decline begins in healthy Chinese individuals remains unclear. This study aimed to identify the chronological age at which small airway dysfunction (SAD) initiates and its predictors within a healthy Chinese...

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IntroductionAllergen immunotherapy (AIT) is a well-established treatment with demonstrated efficacy and safety. However, variability in study outcomes remains a challenge, driven by differences in patient characteristics, study designs, and treatment durations. Moreover, disparities in allergen comp...

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Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent episodes of subcutaneous and/or submucosal angioedema. Pregnancy and breastfeeding may be associated with an increased frequency of attacks. Plasma-derived C1 inhibitor (pdC1INH) is the recommended first-line treatment...

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Primary atopic disorders (PADs) are monogenic conditions associated with severe, early-onset atopic diseases. Clinically, they often overlap with polygenic allergic conditions, making specialized laboratory testing necessary to distinguish them from polygenic atopy. Multisystem involvement, such as...

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The gut microbiota and its metabolites play important roles in the pathogenesis of various diseases. The diversity of the gut microbiota is closely related to the development and function of the human immune system. Dysbiosis, characterized by alterations in the species, quantity, and distribution o...

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BackgroundMite, cockroach, and shellfish (crab, clam, and shrimp) proteins share allergenic epitopes. The determination of specific IgE (sIgE) against cockroach (Blattella germanica, relevant in asthma) and shellfish allergens (relevant in food allergy) using whole-body extracts necessitates detaile...

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BackgroundNSAIDs are widely used for pain management but are second only to antibiotics in causing drug hypersensitivity reactions. Misclassification of these reactions often leads to unnecessary avoidance of the entire drug class, potentially resulting in increased opioid prescribing. This study ai...

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Galectin-9 (Gal-9) is a multifunctional immunomodulatory molecule involved in cell growth, differentiation, adhesion, communication, and death. Galectin-9 mediates its physiological functions through interactions with multiple membrane receptors, including T-cell immunoglobulin mucin-domain containi...

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BackgroundThe role of office-based procedures in rhinology has expanded considerably, driven by advancements in minimally invasive techniques and a growing emphasis on value-based care. These interventions can offer effective management for selected sinonasal conditions while reducing reliance on op...

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IntroductionShrimp is a common but understudied food allergen with relatively high rates of emergency department visits. Here we report the shrimp OIT outcomes in the MOTIF (NCT03504774) clinical trial and discuss some of the challenges with performing this study.MethodsIn this phase 2 clinical tria...

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Health disparities in allergic and immunologic conditions are shaped by unequal exposure to social determinants of health (SDoH), including education, healthcare quality, neighborhood and built environment, social context, and economic stability. This review summarizes recent literature on dispariti...

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PurposeThis review aims to explore the pathophysiological mechanisms and emerging therapies for type 2 chronic rhinosinusitis with nasal polyps (CRSwNP), driven primarily by type 2 inflammation.Search methodsA comprehensive search of relevant literature was performed in databases including PubMed, W...

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The Upper and Lower Airways Northern European Consensus (ULANC) and the European Forum for Research and Education in Allergy and Airways diseases (EUFOREA) organized their first workshop in Copenhagen in January 2024. The aim of the “Primary care physicians and nurses with an interest in Global Airw...

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