Torthaí cuardaigh - "drug allergy"

In the article the interdisciplinary problem of drug allergy being analysed, namely its systemic symptoms. There have been shown the variants of systemic allergic reactions and the characteristics of the toxic epidermal necrolysis or Lyell`s syndrome as one of the most serious and rare form of illne...

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DRESS syndrome is a life-threatening complication rarely encountered in clinical practice. Making a correct diagnosis is complicated not only by the similarity of the clinical manifestation with several other conditions but also delayed in time onset of the first symptoms from the “causative” drug....

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Study of main CYP isoforms activity using «cocktail» method was conducted on patients suffered from drug allergy with different concurrent diseases in order to determine the presence of correlation between drug allergy appearance and changes in biotransformation activity.

Background: Skin prick testing and specific IgE determination do not discriminate between sensitization and clinically relevant insulin allergic reactions, whereas the basophil histamine release assay has proven useful in identifying clinically relevant food and drug allergic reactions. Objective: W...

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Background: The detection of drug-specific activation of T cells in the lymphocyte transformation test (LTT) is mainly based on cell proliferation or cytokine secretion. However, the LTT presents with a varying sensitivity and specificity. The aim of our study was to analyse the genome wide gene exp...

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Health disparities in allergic and immunologic conditions are shaped by unequal exposure to social determinants of health (SDoH), including education, healthcare quality, neighborhood and built environment, social context, and economic stability. This review summarizes recent literature on dispariti...

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Background. Dental care is essential for all hospitalized patients with Stevens-Johnson syndrome and/or toxic epidermal necrolysis (SJS/TEN), the clinical cases of which are reported annually in scientific journals. Purpose of publication was analysis of dental care from clinical reports about S...

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Given the high prevalence of allergic and cardiovascular diseases, clinicians must remain vigilant to the possibility of Kounis syndrome (KS), which involves the cooccurrence of an allergic reaction and acute myocardial infarction (AMI). The article describes a case of KS in a 62-year-old patient, w...

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Relevance. Despite the fact that the pharmacological effect of drugs is well known and studied, unfortunately, it is impossible to predict the development of drug allergies, since the individual characteristics of the body's reactivity are of great importance in its development. The goal is to...

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Background. Enzyme replacement therapy (ERT) with iduronate-2-sulfatase recombinant forms (idursulfase and idursulfase beta) is effective for the management of mucopolysaccharidosis type II (MPS II). Patients with Hunter syndrome require lifelong ERT that can negate endogenous enzyme deficiency. How...

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INTRODUCTION. Allergic drug reactions in hospitalised patients limit the opportunities for rational pharmacotherapy and increase the risk of polypharmacy due to the need for managing the patient’s condition and prescribing anti-allergic agents. An objective assessment of the prevalence of inpatient...

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Adverse drug reactions (ADR) are injuries caused by taking a medication. For the purpose of an objective analysis of the reasons and mechanisms of ADR, with a view to developing the methods for their relief and prevention, one should use standard criteria for the characterization of ADR. Typically,...

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