Resultados de búsqueda - "Major depressive disorder"
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Major depressive disorder and the microbiome-gut-brain axis
Publicado 2025-04-01Materias: Enlace del recursoThe central nervous system and the gastrointestinal tract are connected bidirectionally via the gut-brain axis (GBA). According to the gut microbiota hypothesis, changes in the composition and activity of the gut microbiota can affect the GBA, contributing to the onset of mental illnesses such as de...
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Biological Prediction of Suicidal Behavior in Patients with Major Depressive Disorder
Publicado 2012Enlace del recursoNone
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Comprehensive Characterization of Antidepressant Pharmacogenetics: A Systematic Review of Studies in Major Depressive Disorder
Publicado 2025-06-01Materias: “…major depressive disorder…”ABSTRACT Pharmacogenetics is a promising strategy to facilitate individualized care for patients with Major Depressive Disorder (MDD). Research is ongoing to identify the optimal genetic markers for predicting outcomes to antidepressant therapies. The primary aim of this systematic review was to sum...
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Deciphering transcriptomic signatures in schizophrenia, bipolar disorder, and major depressive disorder
Publicado 2025-07-01Materias: Enlace del recursoSchizophrenia (SCZ), Bipolar Disorder (BD), and Major Depressive Disorder (MDD) are severe psychiatric conditions that share overlapping clinical symptoms, yet they differ in their underlying molecular mechanisms. Despite extensive research, the biological foundations of these disorders remain incom...
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Epidemiology of major depressive disorder in mainland china: a systematic review.
Publicado 2013-01-01“…<h4>Background</h4>Major depressive disorder (MDD) is one of the important causes of disease burden in the general population. …”<h4>Background</h4>Major depressive disorder (MDD) is one of the important causes of disease burden in the general population. Given the experiencing rapid economic and social changes since the early 1990s and the internationally recognized diagnostic criteria and interview instruments a...
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The efficacy and safety of 10 mg vortioxetine in the treatment of major depressive disorder: a meta-analysis of randomized controlled trials
Publicado 2016-02-01Materias: Enlace del recursoGuangjian Li, Xu Wang, Dihui Ma Department of Neurology and Neuroscience Center, First Hospital of Jilin University, Changchun, People&rsquo;s Republic of China Background: Vortioxetine is an investigational multimodal antidepressant. We conducted this meta-analysis to assess the efficacy...
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Medication non-adherence in depression: a systematic review and metanalysis
Publicado 2025-07-01Materias: Enlace del recursoAbstract Objective: Medication non-adherence is frequently reported in patients with major depressive disorder (MDD). The objective of this review is to consolidate data on the prevalence of non-adherence to antidepressant in MDD. Methods: A systematic review with meta-analysis was performed accor...
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5-HTR1A and 5-HTR2A genetic polymorphisms and SSRI antidepressant response in depressive Chinese patients
Publicado 2016-07-01Materias: Enlace del recursoZai-Quan Dong,1,* Xi-Rong Li,2,* Lin He,3,4 Guang He,3,4 Tao Yu,3,4 Xue-Li Sun1 1Psychological Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 2Mental Health Center, First Affiliated Hospital, Chongqing Medical University, Chongqing, 3Bio-X Institutes, Key Laboratory for the Gene...
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The Role of Vitamin D in the Management of Major Depressive Disorder: A Systematic Review
Publicado 2025-05-01Materias: Enlace del recurso<b>Background/Objective:</b> Depression is a widespread and complex disorder, constituting a major public health concern due to its significant impact on mental health. Because of the limitations of major depressive disorder (MDD) treatment, recent research on depression management has f...
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Implications of the choice of method to identify major depressive disorder in large research cohorts
Publicado 2025-09-01“…Background: Clinical heterogeneity and variations in methods to identify major depressive disorder (MDD) across studies compromise replicability of research findings. …”Background: Clinical heterogeneity and variations in methods to identify major depressive disorder (MDD) across studies compromise replicability of research findings. This study evaluated potential implications of different MDD case definitions in a large biobank cohort. Methods: Among Mayo Clinic B...
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Economic costs associated with insomnia in adults with subthreshold depression or major depressive disorder
Publicado 2025-07-01“…Aims To estimate healthcare service use and costs associated with insomnia in Australian adults experiencing subthreshold depression or major depressive disorder (MDD). Method Healthcare service use and productivity loss were extracted from the cross-sectional 2020–2022 National Survey of Mental Health and Wellbeing data. …”Background Previous studies have found substantial costs to be associated with depression and insomnia (as separate entities). Aims To estimate healthcare service use and costs associated with insomnia in Australian adults experiencing subthreshold depression or major depressive disorder (MDD)....
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The effects of cognitive therapy versus 'treatment as usual' in patients with major depressive disorder.
Publicado 2011-01-01“…<h4>Background</h4>Major depressive disorder afflicts an estimated 17% of individuals during their lifetimes at tremendous suffering and costs. …”<h4>Background</h4>Major depressive disorder afflicts an estimated 17% of individuals during their lifetimes at tremendous suffering and costs. Cognitive therapy may be an effective treatment option for major depressive disorder, but the effects have only had limited assessment in system...
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Symptom networks in major depressive disorder and treatment response: special focus on TRD
Publicado 2025-01-01Materias: “…major depressive disorder…”Abstract Background Heterogeneous symptoms in major depression contribute to unsuccessful antidepressant treatment, termed treatment-resistant depression (TRD). Psychometric network modeling conceptualizes depression as interplay of symptoms with potential benefits for treatment; however, a knowledg...
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The experiences of mental healthcare users regarding the quality of their major depressive disorder treatment
Publicado 2025-07-01Materias: “…major depressive disorder…”Background: Millions of people worldwide are affected by major depressive disorder (MDD). However, those with MDD do not receive treatment. More studies have been conducted on the efficacy of medications rather than the subjective experiences of mental healthcare users (MHCUs). Aim: This study was...
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Identification of Genes in Diagnosing Major Depressive Disorder with Anorexia Through Bioinformatics Analysis
Publicado 2025-07-01Materias: “…Major depressive disorder，Anorexia，Inflammation，Bioinformatics analysis…”Fengtao Guo,1,2 Ying Li,2,3 Junxiang Cheng,1,2 Xinxia Wang,1,2 Wei Hu,1,2 Kun Zhang,4 Xushu Jing,1,2 Jinrui Xing,1,2 Zhifen Liu,1 Huanhu Zhang,2,5 Penghong Liu1,2 1Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Shanxi Medical Univ...
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Common Metabolomic Changes in Various Drug Treatments for Major Depressive Disorder Are Related to Purine Metabolism
Publicado 2025-06-01Materias: “…drug treatment; inosine; major depressive disorder; metabolomics…”Various factors influence the pathogenesis of major depressive disorder (MDD). Its heterogeneous nature complicates the identification of underlying biological mechanisms, limiting diagnostic and therapeutic advances. Stratifying MDD patients into biologically distinct subgroups and identifying shar...
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Treatment discontinuation and tolerability as a function of dose and titration of duloxetine in the treatment of major depressive disorder
Publicado 2016-01-01Materias: Enlace del recursoEiji Harada,1 Osamu Shirakawa,2 Yoichi Satoi,3 Lauren B Marangell,4 Rodrigo Escobar5 1Eli Lilly Japan K.K., Medicines Development Unit Japan, Medical Science, Kobe, 2Department of Neuropsychiatry, Kinki University Faculty of Medicine, Osakasayama, 3Eli Lilly Japan K.K., Medicines Development Unit J...
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Analysis of treatment patterns and persistence on branded and generic medications in major depressive disorder using retrospective claims data
Publicado 2016-10-01Materias: “…Major depressive disorder…”Caitlyn T Solem,1 Ahmed Shelbaya,2,3 Yin Wan,1 Chinmay G Deshpande,1 Jose Alvir,2 Elizabeth Pappadopulos2 1Pharmerit International, Real World Evidence/Data Analytics, Bethesda, MD, 2Pfizer, Inc., Global Health Outcomes, New York, NY, 3Epidemiology Department of Mailman&rsquo;s School of Pu...
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Suicide attempts in elderly Han Chinese patients with major depressive disorder: prevalence and associated factors
Publicado 2025-09-01Materias: “…Major depressive disorder…”Objective: Suicide attempts (SA) are common in elderly patients with major depressive disorder (MDD), but few studies have focused on the prevalence and associated factors in elderly Chinese Han patients with MDD. Method: A total of 266 first episode and drug naïve older patients with MDD (age ≥ 50 ...
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Investigating Psychiatric Disorders in Patients with Suicide Attempt
Publicado 2024-05-01Materias: Enlace del recursoBackground: Attempting suicide is considered one of the important indicators of the mental health of individuals in society. One of the important issues in suicide is psychiatric disorders and related factors. Given that no comprehensive study was conducted in Yazd province, this study aimed to asse...
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