The pharmacokinetics effects of the MCAO model on senkyunolide I in pseudo germ-free rats after oral co-administration of Chuanxiong and warfarin

The pharmacokinetics effects of the MCAO model on senkyunolide I in pseudo germ-free rats after oral co-administration of Chuanxiong and warfarin

AimTo investigate the pharmacokinetics effects of a middle cerebral artery occlusion (MCAO) model on senkyunolide I (SEI) in pseudo germ-free rats after oral co-administration of Chuanxiong and warfarin.MethodsRats were divided randomly into WC_H, WS_H, WC_HF, WS_HF, WC, WS, WC_F, and WS_F groups (W...

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Bibliographic Details
Main Authors: Haigang Li, Fang Li, Yi Zhou, Zhongjun Xiang, Bilan Zhou, Bin Lan, Xiaoling Ruan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
senkyunolide I
Chuanxiong
warfarin
pharmacokinetics
MCAO
pseudo germ-free
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1577757/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1577757/full

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