Association between triglyceride-glucose index multiplied by waist circumference and H-type hypertension among Chinese adults
BackgroundsThe triglyceride-glucose index combined with waist circumference (TyG-WC) has good predictive performance for cardiovascular disease, but the relationship of TyG-WC with H-type hypertension (HTH) is still unclear.ObjectsTo explore the association between TyG-WC and HTH, and provide theore...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1589488/full |
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| author | Yiwei Peng Yiwei Peng Yiwei Peng Yiwei Peng Ling Li Ling Li Ling Li Minqi Li Minqi Li Minqi Li Jie Wang Jie Wang Jie Wang Tianyao Long Tianyao Long Tianyao Long Tianyao Long Liuyangyi Zheng Liuyangyi Zheng Liuyangyi Zheng Liuyangyi Zheng Xuan Tan Xuan Tan Xuan Tan Xuan Tan Xiuqin Hong Xiuqin Hong Xiuqin Hong Xiuqin Hong |
| author_facet | Yiwei Peng Yiwei Peng Yiwei Peng Yiwei Peng Ling Li Ling Li Ling Li Minqi Li Minqi Li Minqi Li Jie Wang Jie Wang Jie Wang Tianyao Long Tianyao Long Tianyao Long Tianyao Long Liuyangyi Zheng Liuyangyi Zheng Liuyangyi Zheng Liuyangyi Zheng Xuan Tan Xuan Tan Xuan Tan Xuan Tan Xiuqin Hong Xiuqin Hong Xiuqin Hong Xiuqin Hong |
| author_sort | Yiwei Peng |
| collection | DOAJ |
| description | BackgroundsThe triglyceride-glucose index combined with waist circumference (TyG-WC) has good predictive performance for cardiovascular disease, but the relationship of TyG-WC with H-type hypertension (HTH) is still unclear.ObjectsTo explore the association between TyG-WC and HTH, and provide theoretical basis for the prevention and treatment of HTH in the community population.MethodsThe study used multi-stage cluster random sampling to collect representative samples from urban and rural populations in Hunan Province. HTH was defined as primary hypertension with homocysteine ≥15 μmol/L. Logistic regression and restricted cubic spline (RCS) models analyzed the TyG-WC index's association with HTH. Receiver operating characteristic (ROC) curve analysis compared TyG, WC, TyG-BMI, and TyG-WC in diagnosing HTH. An additive interaction analysis evaluated the synergistic effect of TyG and WC on HTH. Comparative analyses were conducted on the association between the TyG-WC index and both types of hypertension in the general population.Results4,012 subjects were included in this study, and the prevalence of HTH was 19.77%. After adjusting for multiple confounding factors, participants with the highest quartile of TyG-WC had a higher risk of developing HTH compared to those with the lowest quartile of TyG-WC, with OR values of 3.182 (95% CI: 2.370–4.272, P < 0.001). RCS analysis revealed a significant correlation between TyG-WC index and HTH (overall trend P < 0.001). The correlation between TyG-WC and HTH still existed in subgroup analysis. ROC curve analysis showed that TyG-WC has higher predictive value for HTH compared to other variables (AUC = 0.676, 95%CI: 0.655–0.696, P = 0.010). Interaction analysis showed an additive effect between TyG and WC, with individuals having both high TyG and high WC exhibiting a 1.66 times higher HTH risk than those with low TyG and low WC. TyG-WC demonstrated a stronger association with HTH than with general hypertension.ConclusionThe TyG-WC index has high predictive value in identifying HTH, being a promising biomarker for HTH. Our findings provide theoretical basis for the prevention and treatment of HTH in the community population by controlling blood lipid, blood glucose, and waist circumference levels. |
| format | Article |
| id | doaj-art-ff02b6f640054b5e9a5027de02bdda7c |
| institution | Matheson Library |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-ff02b6f640054b5e9a5027de02bdda7c2025-07-10T05:29:55ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-07-011210.3389/fcvm.2025.15894881589488Association between triglyceride-glucose index multiplied by waist circumference and H-type hypertension among Chinese adultsYiwei Peng0Yiwei Peng1Yiwei Peng2Yiwei Peng3Ling Li4Ling Li5Ling Li6Minqi Li7Minqi Li8Minqi Li9Jie Wang10Jie Wang11Jie Wang12Tianyao Long13Tianyao Long14Tianyao Long15Tianyao Long16Liuyangyi Zheng17Liuyangyi Zheng18Liuyangyi Zheng19Liuyangyi Zheng20Xuan Tan21Xuan Tan22Xuan Tan23Xuan Tan24Xiuqin Hong25Xiuqin Hong26Xiuqin Hong27Xiuqin Hong28Clinical Epidemiology Research Office, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaKey Laboratory of Molecular Epidemiology, Hunan Normal University, Changsha, ChinaDepartment of Epidemiology and Statistics, Hunan Normal University, Changsha, ChinaMedical Department, Hunan Normal University, Changsha, ChinaClinical Epidemiology Research Office, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaKey Laboratory of Molecular Epidemiology, Hunan Normal University, Changsha, ChinaMedical Department, Hunan Normal University, Changsha, ChinaClinical Epidemiology Research Office, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaKey Laboratory of Molecular Epidemiology, Hunan Normal University, Changsha, ChinaMedical Department, Hunan Normal University, Changsha, ChinaClinical Epidemiology Research Office, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaKey Laboratory of Molecular Epidemiology, Hunan Normal University, Changsha, ChinaMedical Department, Hunan Normal University, Changsha, ChinaClinical Epidemiology Research Office, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaKey Laboratory of Molecular Epidemiology, Hunan Normal University, Changsha, ChinaDepartment of Epidemiology and Statistics, Hunan Normal University, Changsha, ChinaMedical Department, Hunan Normal University, Changsha, ChinaClinical Epidemiology Research Office, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaKey Laboratory of Molecular Epidemiology, Hunan Normal University, Changsha, ChinaDepartment of Epidemiology and Statistics, Hunan Normal University, Changsha, ChinaMedical Department, Hunan Normal University, Changsha, ChinaClinical Epidemiology Research Office, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaKey Laboratory of Molecular Epidemiology, Hunan Normal University, Changsha, ChinaDepartment of Epidemiology and Statistics, Hunan Normal University, Changsha, ChinaMedical Department, Hunan Normal University, Changsha, ChinaClinical Epidemiology Research Office, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaKey Laboratory of Molecular Epidemiology, Hunan Normal University, Changsha, ChinaDepartment of Epidemiology and Statistics, Hunan Normal University, Changsha, ChinaMedical Department, Hunan Normal University, Changsha, ChinaBackgroundsThe triglyceride-glucose index combined with waist circumference (TyG-WC) has good predictive performance for cardiovascular disease, but the relationship of TyG-WC with H-type hypertension (HTH) is still unclear.ObjectsTo explore the association between TyG-WC and HTH, and provide theoretical basis for the prevention and treatment of HTH in the community population.MethodsThe study used multi-stage cluster random sampling to collect representative samples from urban and rural populations in Hunan Province. HTH was defined as primary hypertension with homocysteine ≥15 μmol/L. Logistic regression and restricted cubic spline (RCS) models analyzed the TyG-WC index's association with HTH. Receiver operating characteristic (ROC) curve analysis compared TyG, WC, TyG-BMI, and TyG-WC in diagnosing HTH. An additive interaction analysis evaluated the synergistic effect of TyG and WC on HTH. Comparative analyses were conducted on the association between the TyG-WC index and both types of hypertension in the general population.Results4,012 subjects were included in this study, and the prevalence of HTH was 19.77%. After adjusting for multiple confounding factors, participants with the highest quartile of TyG-WC had a higher risk of developing HTH compared to those with the lowest quartile of TyG-WC, with OR values of 3.182 (95% CI: 2.370–4.272, P < 0.001). RCS analysis revealed a significant correlation between TyG-WC index and HTH (overall trend P < 0.001). The correlation between TyG-WC and HTH still existed in subgroup analysis. ROC curve analysis showed that TyG-WC has higher predictive value for HTH compared to other variables (AUC = 0.676, 95%CI: 0.655–0.696, P = 0.010). Interaction analysis showed an additive effect between TyG and WC, with individuals having both high TyG and high WC exhibiting a 1.66 times higher HTH risk than those with low TyG and low WC. TyG-WC demonstrated a stronger association with HTH than with general hypertension.ConclusionThe TyG-WC index has high predictive value in identifying HTH, being a promising biomarker for HTH. Our findings provide theoretical basis for the prevention and treatment of HTH in the community population by controlling blood lipid, blood glucose, and waist circumference levels.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1589488/fullH-type hypertensiontriglyceride glucose indexthe waist circumferencecross-sectional studycommunity population |
| spellingShingle | Yiwei Peng Yiwei Peng Yiwei Peng Yiwei Peng Ling Li Ling Li Ling Li Minqi Li Minqi Li Minqi Li Jie Wang Jie Wang Jie Wang Tianyao Long Tianyao Long Tianyao Long Tianyao Long Liuyangyi Zheng Liuyangyi Zheng Liuyangyi Zheng Liuyangyi Zheng Xuan Tan Xuan Tan Xuan Tan Xuan Tan Xiuqin Hong Xiuqin Hong Xiuqin Hong Xiuqin Hong Association between triglyceride-glucose index multiplied by waist circumference and H-type hypertension among Chinese adults Frontiers in Cardiovascular Medicine H-type hypertension triglyceride glucose index the waist circumference cross-sectional study community population |
| title | Association between triglyceride-glucose index multiplied by waist circumference and H-type hypertension among Chinese adults |
| title_full | Association between triglyceride-glucose index multiplied by waist circumference and H-type hypertension among Chinese adults |
| title_fullStr | Association between triglyceride-glucose index multiplied by waist circumference and H-type hypertension among Chinese adults |
| title_full_unstemmed | Association between triglyceride-glucose index multiplied by waist circumference and H-type hypertension among Chinese adults |
| title_short | Association between triglyceride-glucose index multiplied by waist circumference and H-type hypertension among Chinese adults |
| title_sort | association between triglyceride glucose index multiplied by waist circumference and h type hypertension among chinese adults |
| topic | H-type hypertension triglyceride glucose index the waist circumference cross-sectional study community population |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1589488/full |
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