Pathogenetic factors of ulcerative colitis: mainstream for 2020
The causes of ulcerative colitis are still unknown. Scientists made important advances in understanding the pathogenesis of this disease in the 21st century. Complex involvement of an impaired immune response in relation to antigens of the intestinal microbiota in genetically predisposed individu...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2021-07-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/4389 |
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| author | G. R. Bicbavova M. A. Livzan M. Yu. Lozinskaya |
| author_facet | G. R. Bicbavova M. A. Livzan M. Yu. Lozinskaya |
| author_sort | G. R. Bicbavova |
| collection | DOAJ |
| description | The causes of ulcerative colitis are still unknown. Scientists made important advances in understanding the pathogenesis of this disease in the 21st century. Complex involvement of an impaired immune response in relation to antigens of the intestinal microbiota in genetically predisposed individuals under the influence of certain environmental factors was revealed. The factors that disrupt the epithelial barrier and alter the composition of the intestinal microbiota trigger the onset of the disease, thereby stimulating an impaired immune response. Recent studies have discovered completely new hypotheses of its origin and development, gradually interpreting the already known pathogenetic mechanisms of the disease. In this review, we focused on the new concepts in the pathogenesis of ulcerative colitis. We examined genetic, environmental, barrier, and microbial factors. We went into detail on the structure and role of the epithelial barrier, identified specific genes that are involved in the regulation of the intestinal epithelial barrier function in ulcerative colitis. We studied the literature containing information on relevant studies in PubMed and Google Scholar citation systems, using such key words as ulcerative colitis, colon microbiota, barrier function, genetic predisposition, and predisposing factors. |
| format | Article |
| id | doaj-art-fe2b7f61e22f4fe59dfb2776c6345dfe |
| institution | Matheson Library |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-fe2b7f61e22f4fe59dfb2776c6345dfe2025-08-04T16:45:43ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842021-07-0120213013810.20538/1682-0363-2021-2-130-1382790Pathogenetic factors of ulcerative colitis: mainstream for 2020G. R. Bicbavova0M. A. Livzan1M. Yu. Lozinskaya2Omsk State Medical UniversityOmsk State Medical UniversityOmsk State Medical UniversityThe causes of ulcerative colitis are still unknown. Scientists made important advances in understanding the pathogenesis of this disease in the 21st century. Complex involvement of an impaired immune response in relation to antigens of the intestinal microbiota in genetically predisposed individuals under the influence of certain environmental factors was revealed. The factors that disrupt the epithelial barrier and alter the composition of the intestinal microbiota trigger the onset of the disease, thereby stimulating an impaired immune response. Recent studies have discovered completely new hypotheses of its origin and development, gradually interpreting the already known pathogenetic mechanisms of the disease. In this review, we focused on the new concepts in the pathogenesis of ulcerative colitis. We examined genetic, environmental, barrier, and microbial factors. We went into detail on the structure and role of the epithelial barrier, identified specific genes that are involved in the regulation of the intestinal epithelial barrier function in ulcerative colitis. We studied the literature containing information on relevant studies in PubMed and Google Scholar citation systems, using such key words as ulcerative colitis, colon microbiota, barrier function, genetic predisposition, and predisposing factors.https://bulletin.ssmu.ru/jour/article/view/4389ulcerative colitisinflammatory bowel diseasemicrobiotapathogenesispredisposing factorsgenetic predisposition |
| spellingShingle | G. R. Bicbavova M. A. Livzan M. Yu. Lozinskaya Pathogenetic factors of ulcerative colitis: mainstream for 2020 Бюллетень сибирской медицины ulcerative colitis inflammatory bowel disease microbiota pathogenesis predisposing factors genetic predisposition |
| title | Pathogenetic factors of ulcerative colitis: mainstream for 2020 |
| title_full | Pathogenetic factors of ulcerative colitis: mainstream for 2020 |
| title_fullStr | Pathogenetic factors of ulcerative colitis: mainstream for 2020 |
| title_full_unstemmed | Pathogenetic factors of ulcerative colitis: mainstream for 2020 |
| title_short | Pathogenetic factors of ulcerative colitis: mainstream for 2020 |
| title_sort | pathogenetic factors of ulcerative colitis mainstream for 2020 |
| topic | ulcerative colitis inflammatory bowel disease microbiota pathogenesis predisposing factors genetic predisposition |
| url | https://bulletin.ssmu.ru/jour/article/view/4389 |
| work_keys_str_mv | AT grbicbavova pathogeneticfactorsofulcerativecolitismainstreamfor2020 AT malivzan pathogeneticfactorsofulcerativecolitismainstreamfor2020 AT myulozinskaya pathogeneticfactorsofulcerativecolitismainstreamfor2020 |