Identification and validation of DNA methylation-driven gene OSR1 as a novel tumor suppressor for the diagnosis and prognosis of breast cancer

Identification and validation of DNA methylation-driven gene OSR1 as a novel tumor suppressor for the diagnosis and prognosis of breast cancer

IntroductionAberrant DNA methylation plays a critical role in the initiation and progression of cancer, yet its association with breast cancer remains inadequately defined. This study aims to clarify the link between methylation-driven genes and breast cancer pathogenesis.MethodsRNA sequencing and D...

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Bibliographic Details
Main Authors: Jian Xu, Biao Yang, Ling Cheng, Chen Gan, Runze Huang, Anlong Li, Han Ge, Longyu Hu, Meiwen Ling, Xinyi Zheng, Bao Zhao, Mingjun Zhang, Huaidong Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Genetics
Subjects:
breast cancer
DNA methylation
TCGA
OSR1
methylation-driven genes
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1583620/full
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