PRIME, a temperature-guided language model revolutionizes protein engineering

QR Code

PRIME, a temperature-guided language model revolutionizes protein engineering

Saved in:

Bibliographic Details
Main Authors:	Yuanxi Yu, Qianhui Wang, Yike Zou
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Series:	Acta Pharmaceutica Sinica B
Subjects:	Protein engineering Directed evolution Pre-trained language model Deep learning Thermal stability Enzyme activity
Online Access:	http://www.sciencedirect.com/science/article/pii/S221138352500245X
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Research Progress in Enzyme Engineering Strategies to Improve the Thermal Stability of Enzymatic Time-Temperature Indicators
by: PENG Huakang, ZHANG Huanzhi, WANG Chenyue, WANG Yao
Published: (2025-05-01)

β-Galactosidase-Catalyzed Transglycosylation of Tyrosol: Substrates and Deep Eutectic Solvents Affecting Activity and Stability
by: Alžbeta Koššuthová, et al.
Published: (2025-05-01)

M3AE-Distill: An Efficient Distilled Model for Medical Vision–Language Downstream Tasks
by: Xudong Liang, et al.
Published: (2025-07-01)

Protein, Nucleic Acid, and Nanomaterial Engineering for Biosensors and Monitoring
by: Milica Crnoglavac Popović, et al.
Published: (2025-07-01)

Selection of target-binding proteins from the information of weakly enriched phage display libraries by deep sequencing and machine learning
by: Tomoyuki Ito, et al.
Published: (2023-12-01)

STUDY OF THE THERMAL STABILITY OF BARNASE PROTEIN MUTANTS WITH MOLKERN SOFTWARE
by: E. S. Fomin, et al.
Published: (2014-12-01)

Major Intrinsic Proteins in Fungi: A Special Emphasis on the XIP Subfamily
by: Jean-Stéphane Venisse, et al.
Published: (2025-07-01)

THE MAIN PROPERTIES AND EVOLUTIONARY FEATURES OF ANTIFREEZE PROTEINS
by: L. L. Bildanova, et al.
Published: (2014-12-01)

Numerical investigation on damage effect of deep hole pre-cracking roof rock and controlling rockburst
by: Qi Hao, et al.
Published: (2025-06-01)

Aspects of enzymatic modification of plant proteins
by: D. S. Kulikov, et al.
Published: (2025-04-01)

Identification, evolution, expression and protein interaction analysis of genes encoding B-box zinc-finger proteins in maize
by: Xiao-hui XU, et al.
Published: (2023-02-01)

Enzymes /
by: Moss, D. W. (Donald William)
Published: (1968)

Morphometric and Enzymatic Changes in Gills of Rainbow Trout After Exposure to Suboptimal Low Temperature
by: Elias Lahnsteiner, et al.
Published: (2025-06-01)

Protease Enzyme Supplementation in Weaning Piglets Fed Reduced Crude Protein Diets: Effects on Gut Health Integrity and Performance Response
by: Nathana Rudio Furlani, et al.
Published: (2025-07-01)

Enhancing drug-target affinity prediction through pre-trained language model and gated multi-head attention
by: Ghina Khoerunnisa, et al.
Published: (2025-05-01)

Mineral deposits and the evolution of the Biosphere report of the Dahlem Workshop on Biospheric Evolution and Precaribrian Metallogeny, Berlin 1980, September 1-5
Published: (1982)

Enzymes /
by: Dixon, Malcolm, 1899-
Published: (1964)

Properties and molecular-structural features of enzymatically hydrolyzed proteins of pea isolate and secondary starch-protein product
by: D. S. Kulikov, et al.
Published: (2025-07-01)

Study of some parameters and Partial purification of prolidase from serum women preeclampsia
by: Hiba H. Rasheed Lateef, et al.
Published: (2023-06-01)

Dietary enzyme-hydrolyzed marine proteins supplementation promotes appetite, enhances lipid and protein metabolism in Litopenaeus vannamei fed reduced fish meal diets
by: Xiaoyue Li, et al.
Published: (2025-10-01)

Modification of Faba Bean Protein Gels Using Thermal Treatment and Calcium Sulphate
by: Andreas Hopf, et al.
Published: (2025-06-01)

Cornified Epithelial Teeth of Jawless Vertebrates Contain Proteins Similar to Keratin-Associated Proteins of Mammalian Skin Appendages
by: Attila Placido Sachslehner, et al.
Published: (2025-05-01)

Determination of the Cardinal Temperatures and Studying the Effect of Temperature on the Efficiency of Priming on Onion Seed (Allium Cepa cv, Zargan)
by: M.A. Askari Sarcheshmeh, et al.
Published: (2019-06-01)

Study of the process of hydrolysis of milk proteins using enzyme preparations of domestic and production
by: E. S. Semenova, et al.
Published: (2023-07-01)

Dietary enzyme-hydrolyzed marine proteins supplementation could improve growth, protein metabolism and immune response in mud crab (Scylla paramamosain)
by: Tiantian Xu, et al.
Published: (2025-09-01)

Introduction to proteins and protein engineering /
by: Robson, Barry
Published: (1986)

Enhancement of Thermal Stability of Ultra-high Temperature-Sterilized Yak Milk by Different Pretreatment Techniques
by: CAO Hongyu, ZHAO Xiaoxuan, WANG Yunna, XIE Ning, LI Xu, PANG Xiaoyang, LÜ Jiaping, YU Jinghua, LI Hongjuan, ZHANG Shuwen
Published: (2025-07-01)

Impact of Carrageenan-Based Encapsulation on the Physicochemical, Structural, and Antioxidant Properties of Freshwater Snail (<i>Bellamya bengalensis</i>) Protein Hydrolysates
by: Anand Vaishnav, et al.
Published: (2025-05-01)

Investigation on the thermal performance of MgO-filled basalt Fiber/PLA composites for high-temperature industrial applications
by: Thandavamoorthy Raja, et al.
Published: (2025-09-01)

Precipitation evolution, aging strengthening and thermal stability in Al–Fe-Mg-Zr eutectic alloy via laser powder bed fusion
by: Feng Li, et al.
Published: (2025-12-01)

Effect of Iron Content on the Thermal Conductivity and Thermal Diffusivity of Orthopyroxene
by: Xinzhuan Guo, et al.
Published: (2024-06-01)

The Effectiveness of using High Protein Products in the Context of Muscle Mass Gain: A review of the Literature
by: Agnieszka Ewelina Markiewicz, et al.
Published: (2025-07-01)

Complexation Strategies for Enhancing Water-Soluble Protein Stability and Functionality: A Comprehensive Review
by: Qing Guo, et al.
Published: (2025-07-01)

Second-phase composite engineering endows Gd3TaO7-based ceramic with broadband infrared radiation
by: Enyu Xie, et al.
Published: (2025-10-01)

QUANTITATIVE DETERMINATION OF HOST CELL PROTEINS (CHO) BY THE METHOD OF ENZYME IMMUNOASSAY IN THE PROTEIN ADALIMUMAB
by: P. M. Isaykina, et al.
Published: (2019-01-01)

THEORETICAL METHODS FOR INVESTIGATING PROTEIN THERMOSTABILITY AND THEIR APPLICATIONS IN BIOLOGY
by: N. A. Alemasov, et al.
Published: (2014-12-01)

Exchange of protein and nitrogen compounds in the bulls when feeding cellulose-contained feed
by: А. V. SHELEVACH, et al.
Published: (2021-12-01)

PACKETCLIP: multi-modal embedding of network traffic and language for cybersecurity reasoning
by: Ryozo Masukawa, et al.
Published: (2025-07-01)

Pre-service Training Prospects in the Algerian University: Between Achievements and Challenges
by: Naziha Ben Osmane
Published: (2021-12-01)

Enzymic hydrolysis of chickpea protein by Alcalase and its antioxidative activities
by: LI Yan-hong, et al.
Published: (2007-07-01)