The Effect of Methylphenidate on The Consciousness Level of Intoxicated Patients; a Double-Blind Clinical Trial
Introduction: Intoxication-related unconsciousness is a frequent and challenging condition in emergency medicine, where rapid interventions are critical to improve patient outcomes. This study aimed to evaluate the efficacy of methylphenidate in improving consciousness levels of intoxicated patient...
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| Format: | Article |
| Language: | English |
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Shahid Beheshti University of Medical Sciences
2025-06-01
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| Series: | Archives of Academic Emergency Medicine |
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| Online Access: | https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/2721 |
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| author | Faraz Zandiyeh Maral Ramezani Mahdieh Abiyarghamsari Shahin Shadnia Babak Mostafazadeh Peyman Erfan Talab Evini Omid Mehrpour Mitra Rahimi |
| author_facet | Faraz Zandiyeh Maral Ramezani Mahdieh Abiyarghamsari Shahin Shadnia Babak Mostafazadeh Peyman Erfan Talab Evini Omid Mehrpour Mitra Rahimi |
| author_sort | Faraz Zandiyeh |
| collection | DOAJ |
| description |
Introduction: Intoxication-related unconsciousness is a frequent and challenging condition in emergency medicine, where rapid interventions are critical to improve patient outcomes. This study aimed to evaluate the efficacy of methylphenidate in improving consciousness levels of intoxicated patients.
Methods: In this double-blind clinical trial, intoxicated patients over 18 years of age with the Glasgow Coma Score (GCS) 13 and below were studied. 51 people were included in the intervention group and received methylphenidate, while 50 were in the control group and received placebo. Consciousness levels were measured using the Reed score before and at 12, 24, 36, and 48 hours post-intervention and compared between groups using SPSS software version 21.
Results: 101 patients with the mean age of 34± 14.26 (range: 17-81) years were studied (55.4% male). 74.5% of the people in the intervention group achieved the most alert state (a REED score of zero) after 48 hours, compared to only 32% in the control group. The intervention group had significantly lower average Reed scale (0.33) compared to the control group (0.76) 48 hours after the treatment (p = 0.001). Using Methylphenidate in treatment of intoxicated patients showed effect size of 0.703 (95% confidence interval (CI): 0.299-1.104), number needed to treat of 2.17 (95%CI: 1.48 - 3.34), absolute risk reduction of 46% (95%CI: 0.29 -0.67), and relative risk reduction of 57% (95%CI: 0.37 - 0.72).
Conclusion: It seems that, the use of methylphenidate in patients with intoxication can reduce the time it takes for their consciousness to return to a normal level. Since benzodiazepines are the leading cause of poisoning, this study suggests that methylphenidate could be beneficial in cases of benzodiazepine poisoning to aid in cognitive recovery.
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| format | Article |
| id | doaj-art-fd261e5a018d4d77a7fa0996077f53e7 |
| institution | Matheson Library |
| issn | 2645-4904 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Archives of Academic Emergency Medicine |
| spelling | doaj-art-fd261e5a018d4d77a7fa0996077f53e72025-07-02T05:19:39ZengShahid Beheshti University of Medical SciencesArchives of Academic Emergency Medicine2645-49042025-06-0113110.22037/aaemj.v13i1.2721The Effect of Methylphenidate on The Consciousness Level of Intoxicated Patients; a Double-Blind Clinical Trial Faraz ZandiyehMaral RamezaniMahdieh AbiyarghamsariShahin ShadniaBabak MostafazadehPeyman Erfan Talab EviniOmid MehrpourMitra Rahimi0Toxicological Research Center, Excellence Center of Clinical Toxicology, Department of Clinical Toxicology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Introduction: Intoxication-related unconsciousness is a frequent and challenging condition in emergency medicine, where rapid interventions are critical to improve patient outcomes. This study aimed to evaluate the efficacy of methylphenidate in improving consciousness levels of intoxicated patients. Methods: In this double-blind clinical trial, intoxicated patients over 18 years of age with the Glasgow Coma Score (GCS) 13 and below were studied. 51 people were included in the intervention group and received methylphenidate, while 50 were in the control group and received placebo. Consciousness levels were measured using the Reed score before and at 12, 24, 36, and 48 hours post-intervention and compared between groups using SPSS software version 21. Results: 101 patients with the mean age of 34± 14.26 (range: 17-81) years were studied (55.4% male). 74.5% of the people in the intervention group achieved the most alert state (a REED score of zero) after 48 hours, compared to only 32% in the control group. The intervention group had significantly lower average Reed scale (0.33) compared to the control group (0.76) 48 hours after the treatment (p = 0.001). Using Methylphenidate in treatment of intoxicated patients showed effect size of 0.703 (95% confidence interval (CI): 0.299-1.104), number needed to treat of 2.17 (95%CI: 1.48 - 3.34), absolute risk reduction of 46% (95%CI: 0.29 -0.67), and relative risk reduction of 57% (95%CI: 0.37 - 0.72). Conclusion: It seems that, the use of methylphenidate in patients with intoxication can reduce the time it takes for their consciousness to return to a normal level. Since benzodiazepines are the leading cause of poisoning, this study suggests that methylphenidate could be beneficial in cases of benzodiazepine poisoning to aid in cognitive recovery. https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/2721ConsciousnessMethylphenidateMental Status SchedulePoisoning |
| spellingShingle | Faraz Zandiyeh Maral Ramezani Mahdieh Abiyarghamsari Shahin Shadnia Babak Mostafazadeh Peyman Erfan Talab Evini Omid Mehrpour Mitra Rahimi The Effect of Methylphenidate on The Consciousness Level of Intoxicated Patients; a Double-Blind Clinical Trial Archives of Academic Emergency Medicine Consciousness Methylphenidate Mental Status Schedule Poisoning |
| title | The Effect of Methylphenidate on The Consciousness Level of Intoxicated Patients; a Double-Blind Clinical Trial |
| title_full | The Effect of Methylphenidate on The Consciousness Level of Intoxicated Patients; a Double-Blind Clinical Trial |
| title_fullStr | The Effect of Methylphenidate on The Consciousness Level of Intoxicated Patients; a Double-Blind Clinical Trial |
| title_full_unstemmed | The Effect of Methylphenidate on The Consciousness Level of Intoxicated Patients; a Double-Blind Clinical Trial |
| title_short | The Effect of Methylphenidate on The Consciousness Level of Intoxicated Patients; a Double-Blind Clinical Trial |
| title_sort | effect of methylphenidate on the consciousness level of intoxicated patients a double blind clinical trial |
| topic | Consciousness Methylphenidate Mental Status Schedule Poisoning |
| url | https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/2721 |
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