Targeting phospholipase PLAG-15 promotes healthy aging in C. elegans via lysosomal-related genes

Targeting phospholipase PLAG-15 promotes healthy aging in C. elegans via lysosomal-related genes

Summary: Complex lipid metabolism plays a crucial role in regulating aging. We recently discovered that the phospholipid bis(monoacylglycero)phosphate (BMP) increases in aged human muscles and many mouse tissues. The phospholipase PLA2G15 is reportedly involved in BMP synthesis, however, its specifi...

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Bibliographic Details
Main Authors: Sanne van der Rijt, Marte Molenaars, Rashmi Kamble, Weisha Li, Bauke V. Schomakers, Adrie D. Dane, Simone W. Denis, Michel van Weeghel, Frédéric M. Vaz, Alessandra Tammaro, Georges E. Janssens, Arwen W. Gao, Riekelt H. Houtkooper
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Molecular physiology
Lipidomics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225011411
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