Social Isolation Induces Sex‐Specific Differences in Behavior and Gut Microbiota Composition in Stress‐Sensitive Rats

Social Isolation Induces Sex‐Specific Differences in Behavior and Gut Microbiota Composition in Stress‐Sensitive Rats

ABSTRACT Background Social isolation (SI) is an established rat model of chronic stress. We applied this to the stress‐sensitive Wistar Kyoto (WKY) strain to explore brain‐to‐gut interactions associated with mood. Whether SI stress‐induced behavioral changes are sex‐specific or if they affect the mi...

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Bibliographic Details
Main Authors: Charlotte Hurst, Gosia Zobel, Wayne Young, Trent Olson, Nabil Parkar, Jeremy Bracegirdle, Rina Hannaford, Rachel C. Anderson, Julie E. Dalziel
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Brain and Behavior
Subjects:
anxiety
depression
elevated plus maze
gut–brain axis
memory
open field test
Online Access:https://doi.org/10.1002/brb3.70621
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