Sodium-glucose cotransporter-1 inhibition and depression: A Mendelian randomization study

QR Code

Sodium-glucose cotransporter-1 inhibition and depression: A Mendelian randomization study

Objective: The present study aims to determine the causal association between sodium-glucose cotransporter inhibitors and depression, as previous observational studies have concluded a potential link between sodium-glucose cotransporter 1/2 inhibition and depression. Methods: A total of 16 instrumen...

Full description

Saved in:

Bibliographic Details
Main Authors:	Gang Fan, Hong Zuo, Xun Shi, Bo Liu
Format:	Article
Language:	English
Published:	SAGE Publishing 2025-07-01
Series:	SAGE Open Medicine
Online Access:	https://doi.org/10.1177/20503121251352618
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The Efficacy and Safety of Sodium Glucose Cotransporter 2 Inhibitors for Patients with Anticancer Therapy: A Meta-Analysis of Cohort Studies
by: Gang Fan, et al.
Published: (2025-06-01)

The effect of sodium-glucose cotransporter 2 inhibition mediated by blood metabolites in lymphocytic leukemia
by: Diguang Wen, et al.
Published: (2025-11-01)

Inhibitors of sodium-glucose cotransporter 2: risk of ketoacidosis
by: T. M. Bukatina, et al.
Published: (2018-02-01)

Induction of proximal tubular proliferation and lengthening in response to sodium glucose linked cotransporter‐2 inhibition in experimental rats
by: Ellen Wu, et al.
Published: (2025-07-01)

Antifibrotic effects of sodium-glucose cotransporter 2 inhibitors in patients with heart failure
by: Yu. S. Ignatova, et al.
Published: (2024-02-01)

Effects of sodium-glucose cotransport-2 inhibitors treatment in patients with pulmonary hypertension
by: Mohammed Obeidat, et al.
Published: (2025-06-01)

Effect of Sodium-Glucose Cotransporter Type 2 Inhibitors on The Development and Course of Atrial Fibrillation
by: D. A. Ishmaev, et al.
Published: (2025-01-01)

Sodium-glucose cotransporter type 2 inhibitors: successful running after two hares
by: N. B. Perepech, et al.
Published: (2021-07-01)

Evaluation of factors influencing adherence to treatment with sodium-glucose cotransporter type 2 inhibitor
by: D. A. Lebedev, et al.
Published: (2020-10-01)

Role of sodium-glucose cotransporter 2 inhibitors in cardiovascular events in patients with heart failure
by: Eva Muja, et al.
Published: (2025-07-01)

Echocardiographic effects of sodium-glucose cotransporter 2 inhibitors in single ventricle circulatory failure
by: Ralph M.L. Neijenhuis, et al.
Published: (2025-09-01)

Effect of sodium-glucose cotransporter 2 inhibitors on ventricular function in systemic right ventricular failure
by: Lorna Swan, et al.
Published: (2025-07-01)

Clinical use and monitoring of adverse effects of sodium‐glucose cotransporter‐2 inhibitors in persons with type 1 diabetes mellitus
by: Chinatsu Sakai, et al.
Published: (2025-08-01)

Impact of Sodium-Glucose Cotransporter-2 Inhibitors on Post-Transurethral Resection of Bladder Tumor Infection and Prognosis
by: Nobutaka Nishimura, et al.
Published: (2025-07-01)

Sodium‐Glucose Cotransporter 2 Inhibitors in Patients With Systemic Right Ventricles: Incrementally Building the Evidence Base
by: William H. Marshall, et al.
Published: (2025-06-01)

Potential New Applications of Sodium–Glucose Cotransporter-2 Inhibitors Across the Continuum of Cancer-Related Cardiovascular Toxicity
by: Agnieszka Maria Zebrowska, et al.
Published: (2025-06-01)

UDP-Glucose Ceramide Glucosyltransferase Inhibition, Immune Cell Mediation, and Endometriosis Risk: A Mendelian Randomization Study
by: Xue L, et al.
Published: (2025-05-01)

SODIUM-POTASSIUM-CHLORIDE COTRANSPORT IN THE REGULATION OF VASCULAR MYOGENIC TONE
by: S. N. Orlov, et al.
Published: (2014-12-01)

Sodium-glucose cotransporter 2 Inhibitors and COVID-19 outcomes in type 2 diabetes patients: A population-based cohort study
by: Cerina Dubois, et al.
Published: (2025-07-01)

Secondary Erythrocytosis Among Type 2 Diabetes Mellitus Patients With Hypogonadism Using Sodium‐Glucose Cotransporter 2 Inhibitors and Testosterone Replacement Therapy
by: Maharan Kabha, et al.
Published: (2025-07-01)

Acute kidney injury as a risk factor for atrial fibrillation after coronary artery bypass grafting — effects of sodium-glucose cotransporter-2 inhibitors
by: L. V. Kremneva, et al.
Published: (2023-12-01)

Combined Analysis of Transcriptome and Mendelian Randomization Reveals AKT1 and PPARG as Biomarkers Related to Glucose Metabolism in Sepsis
by: Ma J, et al.
Published: (2025-07-01)

Sodium–glucose cotransporter 2 inhibitors ameliorate glutathione cysteine ligase modifier-mediated oxidative stress and subsequent ferroptosis in proximal tubules of diabetic kidney disease
by: Yi-Chun Tsai, et al.
Published: (2025-12-01)

Changes of natriuresis and prediction of cardiovascular events in patients with type 2 diabetes and decompensated heart failure over therapy with sodium-glucose cotransporter 2 inhibitors and standard diuretic therapy
by: O. A. Abdullaev, et al.
Published: (2024-03-01)

Causal Relationship Between Depression, Sleep Disorders, and Constipation: A Mendelian Randomization and Mediation Analysis
by: Wang JX, et al.
Published: (2025-07-01)

Chronic Lung Diseases and Depressive Symptoms in Older Adults: Insights from Observational Studies and Mendelian Randomization
by: Liu H, et al.
Published: (2025-06-01)

Genetic variability in sodium-glucose cotransporter 2 and glucagon-like peptide 1 receptor effect on glycemic and pressure control in type 2 diabetes patients treated with SGLT2 inhibitors and GLP-1RA in the everyday clinical practice
by: Gašper Tonin, et al.
Published: (2025-07-01)

Causal Relationship Between Depression and Traumatic Brain Injury: A Two‐Sample Mendelian Randomization Analysis
by: Shiping Wang, et al.
Published: (2025-07-01)

Metformin reduces the risk of frailty: evidence from a Mendelian randomization study
by: Tong Chen, et al.
Published: (2025-06-01)

Causal Relationship Between Migraine and Postpartum Depression: A Two-Sample Bidirectional Mendelian Randomization Study
by: Zhou XJ, et al.
Published: (2025-07-01)

Comparison of New‐Onset Peripheral Artery Disease in Patients With Type 2 Diabetes Exposed to Sodium–Glucose Cotransporter‐2 Inhibitors, Dipeptidyl Peptidase‐4 Inhibitors, or Glucagon‐Like Peptide‐1 Agonists: A Population‐Based Cohort Study
by: Oscar Hou‐In Chou, et al.
Published: (2025-06-01)

A Novel Depression Risk Prediction Model Using NHANES Data With Mendelian Randomization Validation
by: Lin Lin, et al.
Published: (2025-07-01)

Risk of severe lower extremity arterial disease in elderly Japanese patients with type 2 diabetes: a propensity score-matched model analysis of sodium-glucose cotransporter 2 inhibitors versus metformin
by: Takeshi Horii, et al.
Published: (2025-07-01)

Association between use of sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 agonists, and dipeptidyl peptidase 4 inhibitors with kidney outcomes in patients with type 2 diabetes: A systematic review and network meta-analysis.
by: Shuo Yang, et al.
Published: (2022-01-01)

Type 1 diabetes mellitus, hyperlipidemia, and inflammatory bowel disease: a Mendelian randomization study
by: Xiangyin Liu, et al.
Published: (2024-01-01)

NMRAL1 as a Causal Factor in Postherpetic Neuralgia: A Proteome-Wide Mendelian Randomization Study
by: Ye H, et al.
Published: (2025-05-01)

The association of blood eosinophil levels with sepsis and mortality risk: An observational and Mendelian Randomization Study
by: Jiajia Ren, et al.
Published: (2025-07-01)

Thyroiditis and human blood metabolites: A mendelian randomization study
by: Shao Lijie, et al.
Published: (2025-01-01)

The Impact of Triglycerides on Rheumatoid Arthritis: Risk Factor and Mendelian Randomization Study
by: Liu S, et al.
Published: (2025-05-01)

Causal associations between smoking and ocular diseases: a Mendelian randomization study
by: Zhaohao Huang, et al.
Published: (2025-08-01)