Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Circulating tumor cells (CTCs) are cancer cells that detach from the original site and reach the bloodstream. The most aggressive CTCs survive various immune system attacks and initiate metastasis formation. Importantly, CTCs are not specifically targeted by the current immunotherapies due to the li...
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| Format: | Article |
| Language: | English |
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Wiley
2025-07-01
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| Series: | Molecular Oncology |
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| Online Access: | https://doi.org/10.1002/1878-0261.13665 |
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| author | Doryan Masmoudi Jérome Vialaret Christophe Hirtz Catherine Alix‐Panabières |
| author_facet | Doryan Masmoudi Jérome Vialaret Christophe Hirtz Catherine Alix‐Panabières |
| author_sort | Doryan Masmoudi |
| collection | DOAJ |
| description | Circulating tumor cells (CTCs) are cancer cells that detach from the original site and reach the bloodstream. The most aggressive CTCs survive various immune system attacks and initiate metastasis formation. Importantly, CTCs are not specifically targeted by the current immunotherapies due to the limited knowledge on specific targets. Proteomic profiling can be a powerful tool for understanding some of the immune evasion mechanisms used by cancer cells and particularly CTCs. These mechanisms are generally linked to the expression of specific surface proteins/peptides (i.e. the surfaceome). The study of the peptides that bind to class I molecules of the major histocompatibility complex (MHC‐I) and of the various glycoproteins expressed on CTC surface may open a completely new avenue for the discovery of novel mechanisms of immune evasion. In this review, we discuss how immunopeptidomic and glycoproteomic studies of CTCs that interact with immune cells could help to better understand how metastasis‐initiator CTCs escape the host immune response. We also describe how immunopeptidomic and glycoproteomic studies are carried out. |
| format | Article |
| id | doaj-art-fa6fd0b337ec4e15a7efa34cde40e2c4 |
| institution | Matheson Library |
| issn | 1574-7891 1878-0261 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Oncology |
| spelling | doaj-art-fa6fd0b337ec4e15a7efa34cde40e2c42025-07-08T04:38:21ZengWileyMolecular Oncology1574-78911878-02612025-07-011971979199710.1002/1878-0261.13665Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cellsDoryan Masmoudi0Jérome Vialaret1Christophe Hirtz2Catherine Alix‐Panabières3Laboratory of Rare Circulating Human Cells University Medical Center of Montpellier FranceUniversity of Montpellier, IRMB‐PPC, INM, CHU Montpellier, INSERM CNRS FranceUniversity of Montpellier, IRMB‐PPC, INM, CHU Montpellier, INSERM CNRS FranceLaboratory of Rare Circulating Human Cells University Medical Center of Montpellier FranceCirculating tumor cells (CTCs) are cancer cells that detach from the original site and reach the bloodstream. The most aggressive CTCs survive various immune system attacks and initiate metastasis formation. Importantly, CTCs are not specifically targeted by the current immunotherapies due to the limited knowledge on specific targets. Proteomic profiling can be a powerful tool for understanding some of the immune evasion mechanisms used by cancer cells and particularly CTCs. These mechanisms are generally linked to the expression of specific surface proteins/peptides (i.e. the surfaceome). The study of the peptides that bind to class I molecules of the major histocompatibility complex (MHC‐I) and of the various glycoproteins expressed on CTC surface may open a completely new avenue for the discovery of novel mechanisms of immune evasion. In this review, we discuss how immunopeptidomic and glycoproteomic studies of CTCs that interact with immune cells could help to better understand how metastasis‐initiator CTCs escape the host immune response. We also describe how immunopeptidomic and glycoproteomic studies are carried out.https://doi.org/10.1002/1878-0261.13665cancercirculating tumor cellsglycoproteomicsimmunopeptidomicsproteomics |
| spellingShingle | Doryan Masmoudi Jérome Vialaret Christophe Hirtz Catherine Alix‐Panabières Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells Molecular Oncology cancer circulating tumor cells glycoproteomics immunopeptidomics proteomics |
| title | Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells |
| title_full | Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells |
| title_fullStr | Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells |
| title_full_unstemmed | Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells |
| title_short | Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells |
| title_sort | surfaceome a new era in the discovery of immune evasion mechanisms of circulating tumor cells |
| topic | cancer circulating tumor cells glycoproteomics immunopeptidomics proteomics |
| url | https://doi.org/10.1002/1878-0261.13665 |
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