Retrospective study of definitive therapy for head and neck mucosal melanoma: The RESUME study
Background: Head and neck mucosal melanoma (HNMM) is a rare melanoma. Surgery and radiotherapy (RT) are commonly used; however, their effectiveness remains unclear. In addition, the role of immune checkpoint inhibitors (ICIs) in improving survival in patients with locally advanced HNMM has not been...
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2025-01-01
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| author | Motoo Nomura Naomi Kiyota Yasushi Shimizu Atsushi Motegi Tetsuo Akimoto Takashi Mukaigawa Takashi Fujii Nayuta Tsushima Kiyoto Shiga Taiji Koyama Daisuke Kawakita Akira Ohkoshi Mitsuhiko Nakahira Nobuhiro Hanai Shigeyuki Murono Tsutomu Ueda Hiroki Mitani Mutsukazu Kitano Junichiro Ohori Yuki Saito Nobuhiko Oridate Naoki Nishio Hisayuki Kato Kenji Okami Takenori Ogawa Yasushi Fujimoto Mioko Matsuo Kiyoaki Tsukahara Morimasa Kitamura Satoshi To Shujiro Minami Yosuke Ariizumi Soichi Fumita Akihiro Homma |
| author_facet | Motoo Nomura Naomi Kiyota Yasushi Shimizu Atsushi Motegi Tetsuo Akimoto Takashi Mukaigawa Takashi Fujii Nayuta Tsushima Kiyoto Shiga Taiji Koyama Daisuke Kawakita Akira Ohkoshi Mitsuhiko Nakahira Nobuhiro Hanai Shigeyuki Murono Tsutomu Ueda Hiroki Mitani Mutsukazu Kitano Junichiro Ohori Yuki Saito Nobuhiko Oridate Naoki Nishio Hisayuki Kato Kenji Okami Takenori Ogawa Yasushi Fujimoto Mioko Matsuo Kiyoaki Tsukahara Morimasa Kitamura Satoshi To Shujiro Minami Yosuke Ariizumi Soichi Fumita Akihiro Homma |
| author_sort | Motoo Nomura |
| collection | DOAJ |
| description | Background: Head and neck mucosal melanoma (HNMM) is a rare melanoma. Surgery and radiotherapy (RT) are commonly used; however, their effectiveness remains unclear. In addition, the role of immune checkpoint inhibitors (ICIs) in improving survival in patients with locally advanced HNMM has not been fully evaluated. Patients and methods: This multi-institutional retrospective cohort study analyzed patients with locally advanced HNMM who were treated within the period October 2014 to March 2022. Patients either underwent surgery (S cohort) or received RT (RT cohort). Progression-free survival (PFS) and overall survival (OS) were compared between the S and RT cohorts and between those with and without ICI using propensity score-adjusted models. Results: A total of 304 patients were enrolled: 152 in the S cohort and 152 in the RT cohort. After matching, no significant differences in PFS and OS were observed between the S and RT cohorts. The addition of ICI was associated with significantly improved PFS (hazard ratio 0.50, 95 % confidence interval 0.32–0.80), with a favorable but nonsignificant trend in OS. Subgroup analysis showed that ICI was associated with prolonged OS in the S cohort but had no statistically significant effect in the RT cohort. Disease progression was predominantly distant, irrespective of treatment modality. Conclusion: Surgery and RT were associated with comparable survival outcomes for locally advanced HNMM. ICI was associated with improved PFS, but its relationship with OS needs further investigation. Prospective and randomized studies are needed to refine treatment approaches for this rare malignancy. |
| format | Article |
| id | doaj-art-fa252b4b97d446a59e4ab1cb5f5b37a4 |
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| series | EJC Skin Cancer |
| spelling | doaj-art-fa252b4b97d446a59e4ab1cb5f5b37a42025-07-31T04:54:08ZengElsevierEJC Skin Cancer2772-61182025-01-013100736Retrospective study of definitive therapy for head and neck mucosal melanoma: The RESUME studyMotoo Nomura0Naomi Kiyota1Yasushi Shimizu2Atsushi Motegi3Tetsuo Akimoto4Takashi Mukaigawa5Takashi Fujii6Nayuta Tsushima7Kiyoto Shiga8Taiji Koyama9Daisuke Kawakita10Akira Ohkoshi11Mitsuhiko Nakahira12Nobuhiro Hanai13Shigeyuki Murono14Tsutomu Ueda15Hiroki Mitani16Mutsukazu Kitano17Junichiro Ohori18Yuki Saito19Nobuhiko Oridate20Naoki Nishio21Hisayuki Kato22Kenji Okami23Takenori Ogawa24Yasushi Fujimoto25Mioko Matsuo26Kiyoaki Tsukahara27Morimasa Kitamura28Satoshi To29Shujiro Minami30Yosuke Ariizumi31Soichi Fumita32Akihiro Homma33Department of Head and Neck Oncology and Innovative Treatment, Graduate School of Medicine, Kyoto University, Japan; Department of Clinical Oncology, Kyoto University Hospital, Japan; Correspondence to: 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.Department of Medical Oncology/Hematology, Kobe University Hospital, JapanDepartment of Medical Oncology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, JapanDivision of Radiation Oncology, National Cancer Center Hospital East, JapanDivision of Radiation Oncology, National Cancer Center Hospital East, JapanDivision of Head and Neck Surgery, Shizuoka Cancer Center, JapanDepartment of Head and Neck Surgery, Osaka International Cancer Institute, JapanDepartment of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, JapanDepartment of Otolaryngology-Head and Neck Surgery, Iwate Medical University School of Medicine, JapanDepartment of Medical Oncology/Hematology, Kobe University Hospital, JapanDepartment of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, JapankDepartment of Otorhinolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, JapanDepartment of Head and Neck Surgery, Saitama Medical University International Medical Center, JapanDepartment of Head and Neck Surgery, Aichi Cancer Center Hospital, JapanDepartment of Otolaryngology, Fukushima Medical University, JapanDepartment of Otolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, JapanDepartment of Head and Neck Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, JapanDepartment of Otolaryngology-Head and neck surgery, Faculty of Medicine, Kindai University, JapanDepartment of Otolaryngology, Head and Neck Surgery Kagoshima University Graduate School of Medical and Dental Sciences, JapanDepartment of Otolaryngology, Head and Neck Surgery, The University of Tokyo, JapanDepartment of Otolaryngology - Head and Neck Surgery, Yokohama City University Hospital, JapanDepartment of Otorhinolaryngology, Nagoya University Graduate School of Medicine, JapanDepartment of Otolaryngology - Head and Neck Surgery School of Medicine, Fujita Health University, JapanDepartment of Otolaryngology, Head and Neck Surgery, Tokai University, JapanDepartment of Otolaryngology-Head and Neck Surgery, Gifu University Graduate School of Medicine, JapanDepartment of Otorhinolaryngology, Head and Neck Surgery, Aichi Medical University School of Medicine, JapanDepartment of Otorhinolaryngology Graduate School of Medical Sciences Kyushu University, JapanDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, JapanDepartment of Head and Neck Surgery, Kanazawa Medical University, JapanDepartment of Head and Neck Surgery, National Hospital Organization Kyushu Cancer Center, JapanDepartment of Otolaryngology, NHO Tokyo Medical Center, JapanDepartment of Head and Neck Surgery, Institute of Science Tokyo, JapanDepartment of Medical Oncology, Kindai University Nara Hospital, JapanDepartment of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, JapanBackground: Head and neck mucosal melanoma (HNMM) is a rare melanoma. Surgery and radiotherapy (RT) are commonly used; however, their effectiveness remains unclear. In addition, the role of immune checkpoint inhibitors (ICIs) in improving survival in patients with locally advanced HNMM has not been fully evaluated. Patients and methods: This multi-institutional retrospective cohort study analyzed patients with locally advanced HNMM who were treated within the period October 2014 to March 2022. Patients either underwent surgery (S cohort) or received RT (RT cohort). Progression-free survival (PFS) and overall survival (OS) were compared between the S and RT cohorts and between those with and without ICI using propensity score-adjusted models. Results: A total of 304 patients were enrolled: 152 in the S cohort and 152 in the RT cohort. After matching, no significant differences in PFS and OS were observed between the S and RT cohorts. The addition of ICI was associated with significantly improved PFS (hazard ratio 0.50, 95 % confidence interval 0.32–0.80), with a favorable but nonsignificant trend in OS. Subgroup analysis showed that ICI was associated with prolonged OS in the S cohort but had no statistically significant effect in the RT cohort. Disease progression was predominantly distant, irrespective of treatment modality. Conclusion: Surgery and RT were associated with comparable survival outcomes for locally advanced HNMM. ICI was associated with improved PFS, but its relationship with OS needs further investigation. Prospective and randomized studies are needed to refine treatment approaches for this rare malignancy.http://www.sciencedirect.com/science/article/pii/S2772611825004574Head and neck mucosal melanomaSurgeryRadiotherapyImmunotherapy |
| spellingShingle | Motoo Nomura Naomi Kiyota Yasushi Shimizu Atsushi Motegi Tetsuo Akimoto Takashi Mukaigawa Takashi Fujii Nayuta Tsushima Kiyoto Shiga Taiji Koyama Daisuke Kawakita Akira Ohkoshi Mitsuhiko Nakahira Nobuhiro Hanai Shigeyuki Murono Tsutomu Ueda Hiroki Mitani Mutsukazu Kitano Junichiro Ohori Yuki Saito Nobuhiko Oridate Naoki Nishio Hisayuki Kato Kenji Okami Takenori Ogawa Yasushi Fujimoto Mioko Matsuo Kiyoaki Tsukahara Morimasa Kitamura Satoshi To Shujiro Minami Yosuke Ariizumi Soichi Fumita Akihiro Homma Retrospective study of definitive therapy for head and neck mucosal melanoma: The RESUME study EJC Skin Cancer Head and neck mucosal melanoma Surgery Radiotherapy Immunotherapy |
| title | Retrospective study of definitive therapy for head and neck mucosal melanoma: The RESUME study |
| title_full | Retrospective study of definitive therapy for head and neck mucosal melanoma: The RESUME study |
| title_fullStr | Retrospective study of definitive therapy for head and neck mucosal melanoma: The RESUME study |
| title_full_unstemmed | Retrospective study of definitive therapy for head and neck mucosal melanoma: The RESUME study |
| title_short | Retrospective study of definitive therapy for head and neck mucosal melanoma: The RESUME study |
| title_sort | retrospective study of definitive therapy for head and neck mucosal melanoma the resume study |
| topic | Head and neck mucosal melanoma Surgery Radiotherapy Immunotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2772611825004574 |
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